Index Catalog // ScholarsArchive@OSU

WongCarmenPublicHealthHumanSciencesEffectsSulforaphane.pdf

Creator:: Wong, Carmen P., Hsu, Anna, Buchanan, Alex, Palomera-Sanchez, Zoraya, Beaver, Laura M., Houseman, E. Andres, Williams, David E., Dashwood, Roderick H., and Ho, Emily
Abstract:: Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor suppressor genes silenced...

WongCarmenPublicHealthHumanSciencesEffectsSulforaphane_SupportingInformation.zip

Creator:: Wong, Carmen P., Hsu, Anna, Buchanan, Alex, Palomera-Sanchez, Zoraya, Beaver, Laura M., Houseman, E. Andres, Williams, David E., Dashwood, Roderick H., and Ho, Emily
Abstract:: Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor suppressor genes silenced...

KangYukiLinusPaulingInstitNrf2StatusAffectsTableS2.pdf

Creator:: Rajendran, Praveen, Dashwood, Wan-Mohaiza, Li, Li, Kang, Yuki, Kim, Eunah, Johnson, Gavin, Fischer, Kay A., Löhr, Christiane V., Williams, David E., Ho, Emily, Yamamoto, Masayuki, Lieberman, David A., and Dashwood, Roderick H.
Abstract:: Background: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies. Results: Wild type...

KangYukiLinusPaulingInstitNrf2StatusAffectsTableS1.pdf

Creator:: Rajendran, Praveen, Dashwood, Wan-Mohaiza, Li, Li, Kang, Yuki, Kim, Eunah, Johnson, Gavin, Fischer, Kay A., Löhr, Christiane V., Williams, David E., Ho, Emily, Yamamoto, Masayuki, Lieberman, David A., and Dashwood, Roderick H.
Abstract:: Background: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies. Results: Wild type...

KangYukiLinusPaulingInstitNrf2StatusAffectsFigureS1.pptx

Creator:: Rajendran, Praveen, Dashwood, Wan-Mohaiza, Li, Li, Kang, Yuki, Kim, Eunah, Johnson, Gavin, Fischer, Kay A., Löhr, Christiane V., Williams, David E., Ho, Emily, Yamamoto, Masayuki, Lieberman, David A., and Dashwood, Roderick H.
Abstract:: Background: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies. Results: Wild type...

KangYukiLinusPaulingInstitNrf2StatusAffects.pdf

Creator:: Rajendran, Praveen, Dashwood, Wan-Mohaiza, Li, Li, Kang, Yuki, Kim, Eunah, Johnson, Gavin, Fischer, Kay A., Löhr, Christiane V., Williams, David E., Ho, Emily, Yamamoto, Masayuki, Lieberman, David A., and Dashwood, Roderick H.
Abstract:: Background: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies. Results: Wild type...

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

Creator:: Rajendran, Praveen, Dashwood, Wan-Mohaiza, Li, Li, Kang, Yuki, Kim, Eunah, Johnson, Gavin, Fischer, Kay A., Löhr, Christiane V., Williams, David E., Ho, Emily, Yamamoto, Masayuki, Lieberman, David A., and Dashwood, Roderick H.
Abstract:: Background: The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies. Results: Wild type...
Resource Type:: Article

Plasma metabolites altered by sulforaphane in humans

Creator:: Kelsey, Kimberly J., Atwell, Lauren L., Clarke, John D., Hsu, Anna, Bella, Deborah, Stevens, Jan F., Dashwood, Roderick H., Williams, David E., and Ho, Emily
Abstract:: Consuming cruciferous vegetables such as broccoli sprouts, kale, Brussels sprouts, and bok choy is associated with several health benefits, such as a decreased risk of certain cancers. Cruciferous vegetables contain the glucosinolate, glucoraphanin (GFN). Cutting, chopping or chewing these vegetables releases the enzyme myrosinase, which transforms GFN into sulforaphane (SFN)....
Resource Type:: Poster

Effects of Sulforaphane and 3,3'-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

Creator:: Wong, Carmen P., Hsu, Anna, Buchanan, Alex, Palomera-Sanchez, Zoraya, Beaver, Laura M., Houseman, E. Andres, Williams, David E., Dashwood, Roderick H., and Ho, Emily
Abstract:: Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3′-diindolylmethane (DIM) are promising chemopreventive agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor suppressor genes silenced...
Resource Type:: Article

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Creator:: Shorey, Lyndsey E., Hagman, Amanda M., Williams, David E., Ho, Emily, Dashwood, Roderick H., and Benninghoff, Abby D.
Abstract:: Certain bioactive food components, including indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from cruciferous vegetables, have been shown to target cellular pathways regulating carcinogenesis. Previously, our laboratory showed that dietary I3C is an effective transplacental chemopreventive agent in a dibenzo[def,p]chrysene (DBC)-dependent model of murine T-cell lymphoblastic lymphoma. The primary objective of the...
Resource Type:: Article

ScholarsArchive@OSU

WongCarmenPublicHealthHumanSciencesEffectsSulforaphane.pdf

WongCarmenPublicHealthHumanSciencesEffectsSulforaphane_SupportingInformation.zip

KangYukiLinusPaulingInstitNrf2StatusAffectsTableS2.pdf

KangYukiLinusPaulingInstitNrf2StatusAffectsTableS1.pdf

KangYukiLinusPaulingInstitNrf2StatusAffectsFigureS1.pptx

KangYukiLinusPaulingInstitNrf2StatusAffects.pdf

Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon

Plasma metabolites altered by sulforaphane in humans

Effects of Sulforaphane and 3,3'-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

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