The mechanism of transsulfuration and the role of cystathionine
in the biosynthesis of methionine in yeast were investigated.
Saccharomyces were shown to accumulate cystathionine by use
of the ³⁵S labeled compound.
Cell-free extracts of the wildtype clone as well as methionine
auxotrophs were shown to cleave cystathionine. The enzymatically
produced...