Index Catalog // ScholarsArchive@OSU

Cytotoxic responses of Biomphalaria glabrata hemocytes towards the parasite Schistosoma mansoni : the role of reactive oxygen and nitrogen species

Creator:: Hahn, Ulrike K.
Resource Type:: Dissertation

Regulation of antibiotic production and stress response by the biological control organism Pseudomonas fluorescens Pf-5

Creator:: Whistler, Cheryl A.
Resource Type:: Dissertation

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Creator:: Myscofski, Dawn M.
Abstract:: Streptococcus gordonii (S. gordonii) is being developed as a Gram-positive expression vector for the expression of heterologous proteins. This bacterial expression system takes advantage of the natural pathway of protein export and anchoring on the surface of the bacterium. The expression of heterologous proteins relies on the homologous recombination of...
Resource Type:: Dissertation

Mismatch repair in plants : identification and characterization of Arabidopsis thaliana MutS homolog proteins

Creator:: Culligan, Kevin M.
Resource Type:: Dissertation

Diverse alkane monooxygenase systems in short-chain alkane-utilizing bacteria

Creator:: Hamamura, Natsuko
Resource Type:: Dissertation

Cloning and characterization of GRASP, a novel retinoic acid-induced gene from P19 embryonal carcinoma cells

Creator:: Nevrivy, Daniel
Abstract:: Retinoic acid (RA) exerts important effects in the processes of vertebrate development, cellular growth and differentiation, and homeostasis. However, the mechanisms of action of RA in the control of cellular and developmental processes are incompletely understood, as the retinoid target genes have not been fully characterized. The goal of these...
Resource Type:: Dissertation

The spatial resolution of information in a diffusive cytoplasm

Creator:: Sellers, Drew L.
Abstract:: Every cell is faced continuously with the task of transducing a vast number of external signals into appropriate intracellular responses. In mammalian cells, membrane bound receptors modulate the production of secondary messenger molecules, such as cyclic AMP (cAMP). Cell signaling through second messengers relies on the diffusion of such second...
Resource Type:: Dissertation

Physiological consequences of trichloroethylene degradation by the toluene-oxidizing bacterium Burkholderia cepacia G4

Creator:: Yeager, Chris M.
Abstract:: A number of bacterial species are capable of degrading the widespread environmental pollutant trichloroethylene (TCE) via aerobic cometabolism, but cytotoxic effects that can debilitate the microorganism often accompany this transformation. In this dissertation the effects of TCE degradation on the well-studied, toluene-oxidizing bacterium Burkholderia cepacia G4 were investigated at the...
Resource Type:: Dissertation

Molecular characterization of criniviruses and ilarviruses infecting strawberry

Creator:: Tzanetakis, Ioannis E.
Abstract:: Pallidosis is a disease of strawberry identified in 1957 with an unknown etiology. Two previously uncharacterized viruses in strawberry, Strawberry pallidosis associated virus (SPaV) and Beet pseudo-yellows virus (BPYV), have been found associated with disease symptoms. The complete nucleotide sequence of both viruses was determined and molecular detection protocols developed....
Resource Type:: Dissertation

Dissecting induction of cell cleavage

Creator:: Alsop, G. Bradley
Abstract:: Cytokinesis separates replicated chromosomes and cytoplasm into two daughter cells. In animal cells, this is achieved by the formation of a cleavage furrow that bisects the mitotic (or meiotic) spindle. It is known that the mitotic apparatus defines the cell cleavage plane. However, it is not clear how the mitotic...
Resource Type:: Dissertation

Transcriptional repression mediated by a novel family of C₂H₂ zinc finger proteins

Creator:: Senawong, Thanaset
Abstract:: Two novel and highly related C₂H₂ zinc finger proteins (CTIP1/BCL11A/EVI9 and CTIP2/BCL11B/Rit1) have been implicated in COUP-TF signaling, etiology of myeloid and lymphoid malignancies, and hematopoietic cell development. However, the precise cellular function(s) and the contribution of these proteins to neoplastic processes and hematopoietic cell development remain unknown. The goal...
Resource Type:: Dissertation

Biochemical characterization and mutational analysis of human uracil-DNA glycosylase

Creator:: Chen, Cheng-Yao
Abstract:: PCR-based codon-specific random mutagenesis and site-specific mutagenesis were performed to construct a library of 18 amino acid changes at Arg276 in the conserved leucine-loop of the core catalytic domain of human uracil-DNA glycosylase (UNG). Each Arg276 mutant was then overproduced in E. coli cells and purified to apparent homogeneity by...
Resource Type:: Dissertation

A role for maize ROP2 GTPase in the male gametophyte

Creator:: Carroll, Kirstin Arthur
Abstract:: ROP GTPases are crucial regulators of pollen tube growth. The Rop GTPase family in maize consists of nine known rop genes, ropl-rop9. A subset of these genes (rop2, rop8, and rop9) are expressed in pollen. The rop2 and rop9 genes are a highly conserved duplicate gene pair of ancient origin....
Resource Type:: Dissertation

Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases

Creator:: Song, Shiwei
Abstract:: It is well known that the mitochondrial genome has a much higher spontaneous mutation rate than the nuclear genome. mtDNA mutations have been identified in association with many diseases and aging. mtDNA replication continues throughout the cell cycle, even in post-mitotic cells. Therefore, a constant supply of nucleotides is required...
Resource Type:: Dissertation

Complex architecture of a closterovirus virion

Creator:: Napuli, Alberto J.
Abstract:: In this investigation we examined the molecular architecture and functions associated with the virion components of the Beet yellows virus (BYV), family Closteroviridae. The BYV virions are filamentous particles composed of two coat proteins, the major coat protein (CP), which encapsidates the majority of the genome, and the minor coat...
Resource Type:: Dissertation

The influence of parasite ecology on the genetic structure of parasite populations

Creator:: Criscione, Charles David
Abstract:: Parasites are unique study organisms for evolutionary ecologists. Yet, molecular ecology studies on parasites have lagged far behind those on free-living organisms. The goal of the review in Chapter 2 was to illustrate areas of research that may be of particular interest in relation to the parasitic life style and...
Resource Type:: Dissertation

Genomic-assisted determination of the natural nutrient requirements of the cosmopolitan marine bacterium 'Candidatus Pelagibacter ubique'

Creator:: Tripp, H. James
Abstract:: To identify factors limiting 'Candidatus Pelagibacter ubique' maximum cell density and growth rate in pure culture on seawater, the genome sequence of 'Cand. P. ubique' was analyzed, culturing experiments with organic and inorganic nutrient additions were made, and radiotracer uptake experiments were performed. The genome was sequenced, custom data mining...
Resource Type:: Dissertation

ScholarsArchive@OSU

Cytotoxic responses of Biomphalaria glabrata hemocytes towards the parasite Schistosoma mansoni : the role of reactive oxygen and nitrogen species

Regulation of antibiotic production and stress response by the biological control organism Pseudomonas fluorescens Pf-5

Creation of an efficient protein expression and secretion system in the gram-positive bacterial vector, Streptococcus gordonii

Mismatch repair in plants : identification and characterization of Arabidopsis thaliana MutS homolog proteins

Diverse alkane monooxygenase systems in short-chain alkane-utilizing bacteria

Cloning and characterization of GRASP, a novel retinoic acid-induced gene from P19 embryonal carcinoma cells

The spatial resolution of information in a diffusive cytoplasm

Physiological consequences of trichloroethylene degradation by the toluene-oxidizing bacterium Burkholderia cepacia G4

Molecular characterization of criniviruses and ilarviruses infecting strawberry

Dissecting induction of cell cleavage

Transcriptional repression mediated by a novel family of C₂H₂ zinc finger proteins

Biochemical characterization and mutational analysis of human uracil-DNA glycosylase

A role for maize ROP2 GTPase in the male gametophyte

Precursors for mitochondrial DNA replication : metabolic sources and relations to mutagenesis and human diseases

Complex architecture of a closterovirus virion

The influence of parasite ecology on the genetic structure of parasite populations

Genomic-assisted determination of the natural nutrient requirements of the cosmopolitan marine bacterium 'Candidatus Pelagibacter ubique'

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