In order to address the energy needs of developing countries and remote communities, Oregon State University has proposed the Multi-Application Small Light Water Reactor (MASLWR) design. In order to achieve five years of operation without refueling, use of 8% enriched fuel is necessary.
This dissertation is focused on core design...
Detection technique that proposed utilizing electrochemically controlled, reversible ion extraction into polymeric membrane in an alternating galvanostatic/ potentiostatic mode was introduced. This method is studied in detail to comprehend the advantages of the novel sensor (pulstrode) compared to the potentiometric ion selective electrode (ISE), studies included possible applications and limitations....
A novel method for detecting the peptidase activity of clinically relevant peptidases was investigated using solid-contact electrochemical polyion sensors under chronopotentiometric control. Complete instrumental control over ion-extraction was accomplished by incorporating a lipophilic electrolyte into the ion-selective membrane; the sensors had no intrinsic ion-exchange capabilities. The sensors were used to...
Regression testing is an expensive software engineering activity intended to provide confidence that modifications to a software system have not introduced faults. Test case prioritization techniques help to reduce regression testing cost by ordering test cases in a way that better achieves testing objectives. In this thesis, we are interested...
Many D2d-symmetric 2,2',6,6'-tetrasubstituted biphenyls are
readily prepared via net oxidative dimerization of appropriate
1,3-disubstituted benzenes. Conversion of such proprochiral
compounds to useful C2-symmetric chiral biphenyls requires
formal replacement of two substituents on opposing aryl ring
units with alternate groups. This under exploited
desymmetrization tactic has been demonstrated for the
generation...
In previous work (Blakemore et al. Org. Lett. 2005, 7, 4721; Heterocycles 2006, 70, 609), successful elaborations of the lupine alkaloids (±)-α-isosparteine (dl-2) and (±)-β-isosparteine (dl-3) were realized from a common tetraoxobispidine precursor, 3,7-diallyl -2,4,6,8-tetraoxo-3,7-diazabicyclo[3.3.1]nonane (93). Herein, the tetraoxobispidine approach to lupine alkaloids was extended to a total synthesis of...
The purpose of this research is to investigate how stakeholders involved in collaborative watershed groups in Oregon work with each other to form ideas and take action. Most collaboration efforts include encouraging a high level of trust with a great value placed on relationships and partners, being open and flexible,...
Wildtype sunflower typically produces 12-24% oleic acid (18:1) and 70-82%
linoleic acid (18:2). High-oleic sunflower, by contrast, produces up to 80-94% oleic
acid. The monounsaturated oleic acid has a greater oxidative stability than the
polyunsaturated linoleic acid, predominant in wildtype sunflower, and has greater
nutritional benefits than polyunsaturated and saturated...
A comprehensive tribal-level classification for the world's subfamilies of Hesperiidae, the skipper butterflies, is proposed for the first time. Phylogenetic relationships between tribes and subfamilies are inferred using DNA sequence data from three gene regions: 943 bp of cytochrome oxidase subunit I (COI) (in the mitochondrial genome), 739 bp of...
Selenoprotein W (SeW) is a protein whose function is unknown, but potentially plays a vital role in calcium metabolism, as an indirect link has been established with white muscle disease (WMD). White muscle disease occurs in selenium deficient animals, and is characterized by the precipitation of calcium in muscle, leading...
Antineutrino detectors could provide a valuable addition to current safeguards
regimes. Antineutrinos are an attractive emission to monitor due to their low
interaction cross-section that prevents them from being shielded and the dependence
of their spectrum on the power level and isotopic content of a reactor core. While
there are...
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Dean of the Graduate School
I understand that my dissertation will become part of the
The Department of Nuclear Engineering and Radiation Health Physics (NE/RHP) at Oregon State University (OSU) has been developing an innovative modular reactor plant concept since being initiated with a Department of Energy (DoE) grant in 1999.
This concept, the Multi-Application Small Light Water Reactor (MASLWR), is an integral pressurized water...
How can rigorous forms of testing be supported in a way that is both compatible with the visual aspect of visual programming languages, and usable by the audiences using those languages - even when the audience has no background in software engineering? Visual programs are likely to contain at least...
Test case prioritization techniques schedule test cases for regression testing in an order that increases their ability to meet some performance goal. One performance goal, rate of fault detection, measures how quickly faults are detected within the testing process. The APFD metric had been proposed for measuring the rate of...
Papain-like leader proteases are found in diverse families of human, animal, plant, and fungal positive-strand RNA viruses. In addition to autocatalytic processing, these proteases play a variety of roles in the virus life cycle. In particular, the leader protease (L-Pro) of a prototype member of the Closterovirus genus, Beet yellows...
The Line Integral Convolution (LIC) is a mainstay of flow visualization. It is, however, computationally intensive, which limits its interactivity. Also, when used to view three-dimensional (3D) vector fields, the resulting images are dense and cluttered, making it difficult to perceive the flow on the interior parts of the field....
This thesis presents an automated methodology to calibrate the substrate profile for accurate prediction of substrate parasitics using Green's function based extractors. The technique requires fabrication of only a few test structures and results in an accurate three layered approximation of a heavily doped epitaxial silicon substrate. The obtained substrate...
Real-time, high efficiency neutron spectroscopy has, historically, been a persistent challenge in the field of radiation detection and, for the most part, has gone unsolved. The most promising method to resolve this challenge, is the boron-capture technique using an organic scintillation system (BC-523a). Detectors that utilize this method possess an...
RNA silencing pathways are required for a wide variety of processes in most
eucaryotes. In plants, small-interfering RNA (siRNA) arising from transposons and other
repetitive sequences is associated with heterochromatin formation and maintenance.
MicroRNAs and trans-acting siRNAs encoded at discrete loci function as negative regulators of
gene expression by triggering...
Solid state luminescent sulfides are prepared as powders in order to elucidate the relationship between structure and light emission. While the sulfides studied in this dissertation are known phosphors, materials are investigated in a variety of new ways. Elementary properties and structures of MgS are reviewed, and preparation of MgS...
________________________________________________________________________
Dean of the Graduate School
I understand that my dissertation will become part of the
Regression testing is an expensive testing process used to validate changes made to previously tested software. Different regression testing techniques can have different impacts on the cost-effectiveness of testing. This cost-effectiveness can also vary with different characteristics of test suites. One such characteristic, test suite granularity, reflects the way in...
PDMS membrane-based microvalves are becoming increasingly more important for the control of fluid flow within MECS applications such as microreactors used to synthesize nanoparticles and biological macromolecules. The motivation for pursuing PDMS membrane-based microvalves is for implementing a plug flow microreactor to simulate slug flow yielding a narrower residence time...
In this dissertation we study the electromagnetic properties of planar waveguides
with non-magnetic strongly anisotropic dielectric cores. We develop an analytical
description of the mode propagation in these systems and show that the index
of refraction can be either positive or negative depending on the specific material
parameters. Propagating modes...
Beet yellows virus (BYV) is a filamentous, positive-strand RNA virus that belongs to the family Closteroviridae. BYV particles encapsidate a 15.5 kb RNA and posses complex polar architecture. A long virion body is formed by the major capsid protein(CP), whereas the minor capsid protein (CPm) assembles a short tail that...
In its simplest form, the process of diagnosis is a decision-making process in which the diagnostician performs a sequence of tests culminating in a diagnostic decision. For example, a physician might perform a series of simple measurements (body tem- perature, weight, etc.) and laboratory measurements (white blood count, CT scan,...
7,7'-Dihydroxy-8,8'-biquinolyl (azaBINOL) was prepared from 7-hydroxyquinoline via N,N-dimethyl O-quinol-7-yl carbamate by directed ortho-metallation followed by FeCl₃-mediated oxidative coupling of the 8-lithioquinoline intermediate. Saponification of the resulting dicarbamate provided crystalline (±)-azaBINOL in 56% overall yield. 6,6'-Bis(dimethylaminocarbonyl)-7,7'-dihydroxy-8,8´-biquinolyl was prepared from the same dicarbamate by a double anionic-Fries rearrangement in 43% yield. 7,7'-Bis(diethylamino-carbonyloxy)-6,6'-diiodo-8,8´-biquinolyl...
We have developed a compact micro total analysis system (μTAS) to serve as a platform for in-situ spectrophotometric water quality monitoring. Individual fluidic, optical, and electrical components were designed, developed, and characterized. These components were combined in both an integrated (single lithographic “chip-based” platform) and a modular manner. The microfluidic...
Successful software systems evolve over their lifetimes through the cumulative changes made by software maintainers. As software evolves, the problems resulting from software change worsen, exacerbated by increased system size and complexity, lack of program understanding, amount of effort required to make changes, and number of personnel involved. Experience shows...