Parathyroid hormone (PTH) is directly involved in breast cancer (BC) metastasis, as well as the severity of metastatic tumors. Excess PTH, caused by insufficient dietary calcium, may be an important and preventable factor affecting BC metastasis to bone. PTH levels increase with age in most women, largely due to insufficient...
This internship project (Dr. Dawn Wright—Department of Geoscience) was a synthesis of several aspects of the research process. The documentation of methods consisted of: primary data collection of soil samples, geographical coordinates, georeferencing, basemap creation, laboratory machine operation, laboratory methods, laboratory quality control planning, statistical analysis, and geo-statistical analysis using...
We found that a strains of Yersinia pestis (KIM5) which lacked the nhaA gene was fully attenuated in a plague model. This gene produces a protein of the sodium-proton antiporter family which expel sodium ions from the bacterial cytoplasm in exchange for hydrogen ions, or protons, from the surrounding environment....
The overall objective of this research was to determine which, if any, myosin XI proteins and exocyst proteins play a role in growth of Arabidopsis thaliana hypocotyls and root hairs. This involved the study of whether exocyst and myosin proteins work together during cell expansion within these two plant parts....
The Willamette Valley, west of the Cascade mountain range in the state of Oregon, is home to a growing number of vineyards. This rather recent, booming industry of the region has become an important component of the economy of the state’s agriculture since the late 1960’s, contributing more than $1.56...
Cryopreservation depends on the equilibration of cells with high concentration of cryoprotective agents (CPAs). However, the addition of CPAs can induce damages to the cells. One of the damages is due to too much shrinkage or swell of the cell volume which lead to the cell death during the addition...
Autism and Alexithymia are two disorders characterized by deficiencies in interpersonal and emotional processing. For example, both of these disorders are associated with deficits in the ability to identify and judge the emotions of others. For diagnosis, patients are typically assessed for such deficiencies using published tests of emotion perception...
The condition of a bowel movement is closely reflective of a person's current diet. The Tech-I/O Project utilized the OSU MyPlate smartphone/website application designed to raise awareness of dietary intake and output among college students at OSU.
Upon entering a residential drug and alcohol treatment, typically clients are directed to complete a risk assessment form. Risk assessment forms are anonymous, self-reported questionnaires that inquire about demographics, health, sexual behaviors, as well as drug and alcohol use. The YES house is a youth treatment facility in Corvallis Oregon...
This project deals with a method to optimize in vivo labeling using small fluorescent molecules via bioorthogonal reactions. The reaction used involves our unnatural amino acid 4-(6-methyl-s-tetrazin-3-yl)aminophenylalanine (AMT-Phe). The amino acid is site-specifically incorporated into GFP and then reacted with a labeled, strained trans-cyclooctene, resulting in a labeled protein. However...
Prostate cancer is one of the most prevalent types of cancer in the U.S. and is among the leading causes of death in men of all races. One predictor of advanced prostate cancer and aggressive tumor behavior is the overexpression of the histone methyl transferase EZH2.
EZH2 functions in the...
According to recent research, children’s learning related skills, such as cooperation, self-regulation, responsibility, and independence, are closely related to their academic outcomes (McClelland, Acock, Morrison 2006). While self regulation during preschool and it’s related skills are predictors of later academic achievement, it might be beneficial to determine a simple screening...
Lien, Ruthruff, and Johnston (2010) reported that the attentional control system is able to rapidly and fully switch between different search settings (e.g., red to green), with no carryover. The present study examined whether such impressive flexibility is possible even with more complicated switches, namely singleton search and the feature...
The detection of mammalian FMO’s is important in the understanding of active FMO 2.1 and its role in metabolizing drugs to treat tuberculosis. Refinement of an absolute quantification (AQUA) mass spectrometry method is needed to be able to quantify the different FMO isoforms present in mammalian tissue. We are doing...
The present study examined whether semantic activation for words occurs by encoding whole word shape in addition to individual letters. We used LEET stimuli, where digits were used as parts of words, such as “R34DING” instead of “READING”. Previous studies have suggested that LEET stimuli are encoded in a letter-like...
Phylogenic studies suggest that cells from long-lived species are more resistant to a variety of stressors than short-lived species. However, there is little information on the cellular mechanisms that give rise to increased resistance to stress. Our previous studies have shown that liver proteins from a long-lived species have lower...
In this study, the gene expression levels between 6 month old mice and 26 month
old mice were compared. The purpose of this research was to identify genes that are
differentially regulated due to aging. The results showed 148 significantly differentiated
genes in the analysis of a total of 44,170...
The presence of nitrates and nitrites in food is associated with an increased risk of gastrointestinal cancer and, in infants, methemoglobinemia. Nitrites are produced endogenously through the oxidation of nitric oxide and through a reduction of nitrate by commensal bacteria in the mouth and gastrointestinal tract. Despite the physiologic roles...