Index Catalog // ScholarsArchive@OSU

Use of Artemisinin to Treat Mycoplasma haemolama Infection in Llamas

Creator:: Puccetti, Jessica N.
Abstract:: Mycoplasma haemolamae is associated with mild to marked anemia in stressed, immune-suppressed, and debilitated animals, and may be found in low numbers in healthy animals. The continued presence of the organism, detectable by polymerase chain reaction (PCR)-based assay, may be associated with an underlying problem, such as stress or immune-suppression...
Resource Type:: Honors College Thesis

The Inhibition of a-Amylase and a-Glucosidase by Bioflavonoids

Creator:: Griffith, Anneke M.
Abstract:: Various flavonoid-rich plant extracts have shown efficacy in the treatment of diabetes. Although it is often assumed that dietary flavonoids exert biological antioxidant effects, it is possible that the observed effects work in carbohydrate metabolism. In this study we evaluated the effect of catechins and catechin containing extracts on α-amylase...
Resource Type:: Honors College Thesis

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis

The Challenge of Finding Where SOD Gets Zinc : Identifying Novel Techniques to Recombinantly Express Metallothionein

Creator:: West, Nick
Abstract:: Presentation entitled : The Challenge of Finding Where SOD Gets Zinc: Identifying Novel Techniques to Recombinantly Express Metallothionein / by Nick B. West, Joseph Beckman and Daniel Sudakin
Resource Type:: Honors College Thesis

Survey of rhizosphere associated entomopathogenic fungi on small fruits and Christmas trees in the Willamette Valley, OR

Creator:: Fisher, Joanna J.
Abstract:: The entomopathogenic fungi Metarhizium anisopliae and Beauveria bassiana are commercially available as microbial control agents for the black vine weevil, Otiorhynchus sulcatus (F.) (Coleoptera: Curculionidae), the key root-feeding insect pest in Pacific Northwest small fruits and ornamentals. Understanding habitat selection is critical to improve the efficacy, persistence and cost of...
Resource Type:: Honors College Thesis

Soil solarization effects on plant growth variables of field-grown tree saplings

Creator:: Fraher, Simon
Abstract:: Solarization could be an alternative to chemical controls for soil pathogens and weeds, and it may also influence plant growth factors. Biomass, shoot length, and AMF colonization were examined in red oak (Quercus rubra), Mazzard cherry (Prunus avium), and hawthorn (Crataegus monogyna) at J. Frank Schmidt & Son Co. nursery...
Resource Type:: Honors College Thesis

Soil solarization effects on plant growth variables of field-grown tree saplings

Creator:: Fraher, Simon
Abstract:: Soil solarization has been used throughout the world, but its effect on plant growth variables in ornamental tree saplings in the Willamette Valley are not well documented. Solarization could be an alternative to chemical controls for soil pathogens and weeds, and it may also influence plant growth factors. This study...
Resource Type:: Honors College Thesis

Response of reef fish assemblages to overgrowth of the hydrocoral Millepora complanata by the crustose alga Ramicrusta sp.

Creator:: Adams, AnnaRose
Abstract:: Natural disturbances and human activities can alter the benthic composition of coral reefs and other marine ecosystems. Reef fishes that associate with particular structures on the sea floor, such as coral heads, may be vulnerable to perturbations of those habitats. The spread of a newly discovered crustose alga (Ramicrusta sp.)...
Resource Type:: Honors College Thesis

Reduced toxicity of benzethonium chloride to Escherichia coli through adsorption onto titanium dioxide nanoparticles

Creator:: Waldron, Kerri Raven
Abstract:: Antimicrobial agents are being increasingly used in consumer soaps and detergents, despite a lack of data demonstrating their efficacy in such products. This study investigated the nature of the interaction between different crystalline structures of titanium dioxide nanoparticles and BTC, and explore which structure, if any, could be best used...
Resource Type:: Honors College Thesis

Probing Circadian Clock-Steroid Receptor Interactions in GnRH Neurons

Creator:: Grimwood, Victoria J.
Abstract:: Endogenous circadian clock regulation is essential to normal rhythmicity, particularly the timing of hormone release in the brain. In the context of mammalian reproduction, a surge of a specific hormone, gonadotrophin-releasing hormone (GnRH), initiates a surge of luteinizing hormone (LH) from the pituitary gland, which is required for ovulation in...
Resource Type:: Honors College Thesis

Preliminary Evidence that the Microbial Community may Produce Aliphatic Constituents and Induce Soil Water Repellency as a Response to Desiccation

Creator:: Chilcote, Emma T.
Abstract:: Soil water repellency is one cause of rill soil erosion and overland flow that results in the loss of fertile topsoil. Previous research suggests that since microbial growth depends on temperature/moisture and follows diurnal and seasonal cycles, a biological mechanism would be able to explain the observed seasonality and climate...
Resource Type:: Honors College Thesis

Native wildlife species (Pseudacris regilla) utilizing invasive-dominated habitat in a highly disturbed ecosystem

Creator:: Epperly, Haley K.
Abstract:: The Pacific Treefrog (Pseudacris regilla) is commonly encountered throughout the Pacific Northwest and can be an indicator for ecosystem health. At each life stage P. regilla utilizes a different habitat and therefore it is important to understand habitat use at all life stages to properly manage the ecosystem, however, few...
Resource Type:: Honors College Thesis

Native bees, honeybees and pollination in Oregon cranberries

Creator:: McKenney, Melissa A.
Abstract:: Farmers rely almost exclusively on the imported European honeybee (Apis mellifera L.) for fruit and vegetable crop pollination services. The recent decline in honeybee health has underscored the danger of relying on a single species to provide vital services. Increasing pollinator biodiversity with native bees may provide biological insurance against...
Resource Type:: Honors College Thesis

Native bees, honeybees and pollination in Oregon cranberries

Creator:: McKenney, Melissa A.
Abstract:: Farmers rely almost exclusively on the imported European honeybee (Apis mellifera L.) for fruit and vegetable crop pollination services. The recent decline in honeybee health has underscored he danger of relying on a single species to provide vital services. Increasing pollinator biodiversity with native bees may provide biological insurance against...
Resource Type:: Honors College Thesis

Mycobacterium tuberculosis Selective Adenosine Kinase Nucleoside Polymers for Inhalation Therapy

Creator:: Snow, Erika
Abstract:: Respiratory illnesses caused by both viral and bacterial infection are serious issues for global healthcare providers. With the emergence of new, drug-resistant forms of these diseases, innovative drugs and treatment therapies are needed. M tuberculosis is an infection that affects a large portion of the world’s population each year. Aerosol...
Resource Type:: Honors College Thesis

Mono-substituted isopropylated triaryl phosphate, a major component of Firemaster 550, is anAHR agonist that exhibits AHR-independent cardiotoxicity in zebrafish

Creator:: Gerlach, Cory V.
Abstract:: Firemaster 550 (FM550) is an additive flame retardant mixture used within polyurethane foam and is increasingly found in house dust and the environment due to leaching. In this study, we sought to investigate mono-substituted isopropylated triaryl phosphate (mITP), a major component of FM550, which has been shown to cause cardiotoxicity...
Resource Type:: Presentation and Honors College Thesis

Metagenomics Analysis Reveal Host-Microbe Interactions in Cervical Cancer

Creator:: Lam, Khiem C.
Abstract:: Cervical cancer is the fourth most common cancer in women worldwide. Recently it has been shown that microbiota play a role in some types of cancer. Therefore, to understand whether microbes contribute in any way to the development and progress of cervical cancer, we investigated the cervical microbiome via analysis...
Resource Type:: Presentation and Honors College Thesis

Metabolic Effects in C57B/6J Mice Fed a High-Fat Diet Supplemented with Chromium Picolinate and Chromium Yeast

Creator:: Yu, Wesley
Abstract:: An estimated total of 30.3 million people have diabetes in the United States, a disease characterized by chronic elevation in blood glucose which over time, can lead to a host of health problems. Currently the most common types of diabetes are type 1, type 2, and gestational. The principal hormone...
Resource Type:: Honors College Thesis

Insights into the root-knot nematode (Meloidogyne spp.) microbiome using comparative 16S rDNA metagenomics

Creator:: Carleson, Nick
Abstract:: Root-knot nematodes (Meloidogyne spp.) are one of the most important global plant pathogens. Recent innovations in molecular techniques have allowed increased study of this important pest, including the ability to investigate associated microbiomes. This study used 16S rDNA metagenomic sequencing to characterize the microbiome of Meloidogyne hapla, the northern root-knot...
Resource Type:: Presentation and Honors College Thesis

Insights into the Host Range, Population Decline, and Pathogenicity to Potato of Globodera ellingtonae

Creator:: Baker, Hannah V.
Abstract:: This thesis project has the following specific objectives: (i) Determine pathogenicity of Globodera ellingtonae to potato utilizing two trials conducted over a 16 week period, (ii) Elucidate the host range of G. ellingtonae using a variety of different Solanum weed species and crop species, and (iii) Characterize population decline of...
Resource Type:: Honors College Thesis

Inhibition of α-Amylase and α-Glucosidase by Bioflavonoids

Creator:: Griffith, Anneke M. (Tucker)
Abstract:: Various flavonoid-rich plant extracts have shown efficacy in the treatment of diabetes. Although it is often assumed that dietary flavonoids exert biological antioxidant effects, it is possible that the observed effects work in carbohydrate metabolism. In this study we evaluated the effect of catechins and catechin containing extracts on α-amylase...
Resource Type:: Presentation and Honors College Thesis

Influences of an Anti-inflammatory Drug, Ibuprofen, on Spatial Memory and NMDA Receptor Subunit Expression During Aging

Creator:: Márquez Loza, Alejandra
Abstract:: One of the first cognitive dysfunctions to arise with aging is memory loss, affecting an estimated 85% of elderly in the U.S. over the age of 80 with Age Associated Memory Impairment. A common feature in humans and animals experiencing memory loss with aging is the decline in N-methyl-D-aspartate (NMDA)...
Resource Type:: Honors College Thesis

Geographic variation in the seed mycobiome of Coastal Douglas-fir (Pseudotsuga menziesii var. menziesii)

Creator:: Bergmann, Gillian E.
Abstract:: Seeds are an essential component of plant life histories, and seed endophytes have the potential to influence germination, seedling establishment and development. That said, seed endophytes are a relatively new area of study, both in the factors that influence which taxa are present and how these microbes alter plant function....
Resource Type:: Honors College Thesis

Exploring Pactamycin Biosynthesis

Creator:: Roland, Jessica
Abstract:: Pactamycin, produced by the soil bacterium Streptomyces pactum, is a cytotoxic antibiotic that belongs to the aminocyclitol family of natural products. This antibiotic has shown various forms of biological activity, including antibacterial, antifungal, antimalarial, and antitumor activities. Despite its outstanding biological activity, the mode of formation of its pharmacophore (the...
Resource Type:: Honors College Thesis

Exploring Chromodomain Genes in the Fungus Fusarium graminearum Through Targeted Genetic Manipulation

Creator:: Peters, Alec J.
Abstract:: DNA segments in the fungus Fusarium graminearum were identified as possible genes encoding for chromodomain proteins (CDPs), and targeted for genetic manipulation. Targeted single-gene deletion strains, as wells as GFP-S tag fusion strains, were generated from wildtype F. graminearum protoplasts, and verified strains were screened for phenotypic differences, such as...
Resource Type:: Presentation and Honors College Thesis

Establishing Caenorhabditis elegans as a model for Mycobacterium avium subspecieshominissuis infection and intestinal colonization

Creator:: Ziaie, Navid
Abstract:: Mycobacterium avium subspecies hominissuis (MAH) causes potentially lethal opportunistic infections in immunocompromised individuals. Lack of a good animal model system currently hinders in vivo study of MAH virulence. Here we applied the tractable organism Caenorhabditis elegans (C. elegans), as a surrogate host to study the virulence of MAH. Worms were...
Resource Type:: Honors College Thesis

Effects of Xanthohumol on Biomarkers of Metabolic Syndrome in Obese Rats

Creator:: Moreno Luna, Arlyn Y.
Abstract:: Flavonoids are a large family of compounds synthesized by plants that have a common chemical structure. It is believed that the health effects of fruits and vegetables are primarily due to dietary flavonoids content. Current research indicates that dietary flavonoids show promise for mitigating and/or preventing chronic conditions associated with...
Resource Type:: Honors College Thesis

DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

Creator:: Kernan, Casey P.
Abstract:: DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
Resource Type:: Honors College Thesis

Discovery and Characterization of New Cyanobacterial Natural Products from Moorea sp

Creator:: Cowley, Elise Shylo
Abstract:: Natural products (secondary metabolites) are small organic molecules derived from plants, microbes, and marine organisms that have served as a diverse source of useful compounds pharmaceuticals. New biologically active natural products are critical as anti-infective and cancer drug leads. Cyanobacteria, or blue-green algae, produce diverse cytotoxic metabolites that represent potential...
Resource Type:: Honors College Thesis

De novo Discovery of Novel Long Noncoding RNAs in the North American Beaver

Creator:: Kashyap, Amita
Abstract:: Long noncoding RNAs (lncRNAs) are RNA molecules that are at least 200 nucleotides long and do not encode proteins. lncRNAs have roles in gene regulation, chromatin epigenetics, and molecular scaffolding. In light of mounting evidence implicating species-specific noncoding RNAs and gene regulatory mechanisms in species adaptations, it is reasonable to...
Resource Type:: Honors College Thesis

Cyclic electron flow : Powering unique motility and alternative nitrogen uptake in Synechococcus WH8102 during nitrogen limited growth

Creator:: Dittrich, Jake E.
Abstract:: Global atmospheric carbon levels are continuing to rise from pre-industrial revolution levels. One of the main regulators of global atmospheric carbon levels, and thus climate, is the world's oceans. Unicellular marine cyanobacteria account for a large percent of total marine carbon fixation. We measured chlorophyll-specific ¹⁴C uptake rates (P[superscript b])...
Resource Type:: Honors College Thesis and Presentation

Controlled Orientation of Engineered Carbonic Anhydrase on a Surface : A Model for Protein Immobilization for Biosensors and Biomaterials

Creator:: Brown, Wesley
Abstract:: Current protein immobilization techniques lack defined control over protein orientation. Protein orientation is important for making biosensors and biomaterials that are sensitive and efficient and can be crucial for designing some devices such as immunosensors or direct electron transferring biocells. A new method of protein immobilization is proposed that takes...
Resource Type:: Honors College Thesis

Chromosome visualization in a temperate anemone, Anthopleura elegantissima

Creator:: Shaffer, Lucy J.
Abstract:: Anthopleura elegantissima (Cnidaria: Anthozoa) is an emerging model organism for studying the endosymbiotic relationship between dinoflagellate (genus Symbiodinium) and the cnidarian host. To be developed as a model organism, more genetic resources, like integrated genome and linkage map, are needed. An important validation for developing genomic resources is chromosome number....
Resource Type:: Honors College Thesis

Characterizing PM2.5 with Different Source Contributions

Creator:: Perez, Allison Mae S.
Abstract:: Ubiquitous fine particulate matter (PM2.5) exposures significantly impact global public health, yet little is known about the mechanisms causing these known adverse health effects. Oxidative stress due to PM2.5 associated chemical constituents, such as polycyclic aromatic hydrocarbons (PAHs), is a proposed possible mechanism for PM2.5 mediated health effects. Variations in...
Resource Type:: Honors College Thesis

Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

Creator:: You, Hyekyoung Hannah
Abstract:: Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Resource Type:: Honors College Thesis

Antifungal Properties of Spotted Wing Drosophila (Drosophila suzukii) Larvae

Creator:: Bernert, Ann
Abstract:: Spotted wing drosophila, Drosophila suzukii, is a recently introduced, invasive pest in Oregon. It oviposits in near-mature and mature fruit, and thus is an important concern for the small fruit industry. A crop consultant observed that mature raspberry fruit with D. suzukii larvae do not show symptoms of molds as...
Resource Type:: Honors College Thesis

An Evaluation of Staffing Needs at the Health Clinic in Maunatlala, Botswana

Creator:: Bedge, Sonya S.
Abstract:: As part of the Botswana Global Learning Internship Program, a qualitative study was conducted regarding the current staffing conditions at the local village health clinic in Maunatlala, Botswana. This was a month-long project conducted over the summer of 2018. Students from Oregon State University lived in the village of Maunatlala...
Resource Type:: Honors College Thesis

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