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Filtering by: Has journal Journal of Alloys and Compounds Remove constraint Has journal: Journal of Alloys and Compounds Decade 2010-2019 Remove constraint Decade: 2010-2019 Non-Academic Affiliation Oregon State University. Bioresource Research Remove constraint Non-Academic Affiliation: Oregon State University. Bioresource Research

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  • Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay

    Creator:
    Luker, George W.
    Abstract:
    There exists a growing need to establish a better in vitro model for evaluating PAH toxicity and carcinogenicity and to improve assessments of risk to human health, especially to the complex mixtures that exist in the environment. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants due to the incomplete combustion...
    Resource Type:
    Presentation
    Full Text:
    Contaminated Soils using Mammalian In Vitro Assay Toxicity and Mutagenicity of Polycyclic Aromatic

  • Toxicity and Mutagenicity of Polycyclic Aromatic Hydrocarbons in Contaminated Soils using Mammalian In Vitro Assay

    Creator:
    Luker, George W.
    Abstract:
    There exists a growing need to establish a better in vitro model for evaluating PAH toxicity and carcinogenicity and to improve assessments of risk to human health, especially to the complex mixtures that exist in the environment. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants due to the incomplete combustion...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    compounds that exist in these mixtures further hinder assessment of both hazard and risk that typically

  • Phytochemical characterization of Fagonia indica and its effects on MCF-7 breast cancer cell line

    Creator:
    Kumbi, Yadano
    Abstract:
    Phytochemicals from the genus, Fagonia, have been attracting increasing attention due to their potential beneficial effects on human health, particularly, anti-cancer properties. Certain Fagonia species contain various types of phytochemicals such as saponins, alkaloids, cardiac glycosides, flavonoids, terpenoids, and tannins. In this study, we investigated the phytochemical composition of a...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    setting of 35 V. For analysis of phenolic compounds, compound identification was based on accurate mass

  • Targeting chemotherapeutic resistance in breast cancer

    Creator:
    Avery, Jonathan
    Abstract:
    The Bcl-2 family of proteins regulate cell survival and are targets for cancer therapy. This protein family has also been implicated in chemotherapeutic resistance, the cause of approximately 90% of treatment failure in advanced cancer. We analyzed the expression and the role of the Bcl-2 proteins in chemotherapy resistant breast...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    chemotherapy resistant breast cancer cells, and the utility of a new class of compounds targeting Bcl-2. The

  • Effects of Xanthohumol on Biomarkers of Metabolic Syndrome in Obese Rats

    Creator:
    Moreno Luna, Arlyn Y.
    Abstract:
    Flavonoids are a large family of compounds synthesized by plants that have a common chemical structure. It is believed that the health effects of fruits and vegetables are primarily due to dietary flavonoids content. Current research indicates that dietary flavonoids show promise for mitigating and/or preventing chronic conditions associated with...
    Resource Type:
    Honors College Thesis
    Full Text:
    -Prenylnaringenin and Related Hop (Humulus lupulus L.) Flavonoids. Journal of Clinical Endocrinology & Metabolism

  • Characterizing PM2.5 with Different Source Contributions

    Creator:
    Perez, Allison Mae S.
    Abstract:
    Ubiquitous fine particulate matter (PM2.5) exposures significantly impact global public health, yet little is known about the mechanisms causing these known adverse health effects. Oxidative stress due to PM2.5 associated chemical constituents, such as polycyclic aromatic hydrocarbons (PAHs), is a proposed possible mechanism for PM2.5 mediated health effects. Variations in...
    Resource Type:
    Honors College Thesis
    Full Text:
    attributed to the differing source contributions and thus chemical constituents of PM2.5. To test this

  • Characterization of a Transgenic Mouse for Human Cytochrome P450 1B1 (CYP1B1)

    Creator:
    You, Hyekyoung Hannah
    Abstract:
    Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
    Resource Type:
    Honors College Thesis
    Full Text:
    metabolism of carcinogenic, or suspected carcinogenic compounds, such as PAHs. 7 MATERIALS AND

  • Antifungal Properties of Spotted Wing Drosophila (Drosophila suzukii) Larvae

    Creator:
    Bernert, Ann
    Abstract:
    Spotted wing drosophila, Drosophila suzukii, is a recently introduced, invasive pest in Oregon. It oviposits in near-mature and mature fruit, and thus is an important concern for the small fruit industry. A crop consultant observed that mature raspberry fruit with D. suzukii larvae do not show symptoms of molds as...
    Resource Type:
    Honors College Thesis
    Full Text:
    with the omission of propionic acid and methyl paraben. The purpose of these compounds is to reduce

  • Biogas inhibition of fats, oils, and greases with varying ammonia levels

    Creator:
    Aranda, Ana A.
    Abstract:
    Biogas can be used to generate energy from a wide variety of sources. Wastewater treatment sludge is an effective source of waste to be used for generation of biogas to make energy which can be used to heat homes and run businesses. This would help decrease the use of fossil...
    Resource Type:
    Undergraduate Thesis
    Full Text:
    Mishra, S. (2013). Wastewater Treatment and Reuse: Sustainability Options. Consilience: The Journal of

  • DNA Mismatch Repair-Dependent Suppression of Genotoxicity of Benzo[a]pyrene Diol Epoxide

    Creator:
    Kernan, Casey P.
    Abstract:
    DNA mismatch repair (MMR) plays an important role in preserving genomic stability and reducing cancer risk. Environmental exposures to polycyclic aromatic hydrocarbons (PAHs) are believed to contribute significantly to carcinogenesis. PAHs are found in food, air, water and soil and upon bioactivation can form diol epoxides which are electrophilic in...
    Resource Type:
    Honors College Thesis
    Full Text:
    -proficient and -deficient set. I found an induced mutation rate of 30±5 mutations per 100 nM BPDE using