Targeting chemotherapeutic resistance in breast cancer

Undergraduate Thesis Or Project

Public Deposited

Citeable URL: https://ir.library.oregonstate.edu/concern/undergraduate_thesis_or_projects/gq67js949

Descriptions

Attribute Name	Values
Creator	Avery, Jonathan
Abstract	The Bcl-2 family of proteins regulate cell survival and are targets for cancer therapy. This protein family has also been implicated in chemotherapeutic resistance, the cause of approximately 90% of treatment failure in advanced cancer. We analyzed the expression and the role of the Bcl-2 proteins in chemotherapy resistant breast cancer cells. Further, we investigated the role of a new class of molecules developed in our laboratory that target Bcl-2. These compounds effectively induced death in chemotherapy resistant breast cancer cells and reduced their ability to form colonies. Therefore, our studies have identified a group of compounds that have the potential to treat chemotherapy resistant breast cancer.
License	All rights reserved
Resource Type	Undergraduate Thesis
Date Available	2016-06-20T13:57:14+00:00
Date Issued	2016-06-01
Degree Level	Bachelor's
Degree Name	Bachelor of Science (B.S.)
Degree Field	BioResource Research
Degree Grantor	Oregon State University
Commencement Year	2016
Non-Academic Affiliation	Oregon State University. Bioresource Research
Rights Statement	In Copyright
Related Items	Targeting Chemotherapeutic Resistance through Bcl-2
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]
Replaces	http://hdl.handle.net/1957/59229
Embargo date range	2017-07-27 to 2021-06-21

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