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  • Inhalable Lipid Nanoparticles for Messenger RNA Therapeutics

    Creator:
    Kim, Jeonghwan
    Abstract:
    Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
    Resource Type:
    Dissertation
    Full Text:
    Sahay Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by

  • Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

    Creator:
    Chang, Yvonne
    Abstract:
    The environmental health science community recognizes polycyclic aromatic hydrocarbons (PAHs) as a re-emerging class of environmental pollutants due to their persistence and prominence in mixtures of concern. Due to their widespread distribution in the environment, exposure to PAHs often occur as complex chemical mixtures. Exposures are linked to numerous adverse...
    Resource Type:
    Dissertation
    Full Text:
    . Comparison of BAP and DBC gene signatures showed that a majority of genes (~60%) were uniquely regulated by

  • Influence of Oceanographic Conditions on Copepod (Calanus pacificus) Genetic Expression

    Creator:
    Bynes, Kenya S.
    Abstract:
    RNAseq data among copepods (Calanus pacificus) were sampled and analyzed in relation to oceanographic and climatic conditions to determine if new information derived from such an approach might assist applications that use copepods as ecosystem indicators to predict fishery yields. These samples were taken as part of long-term studies conducted...
    Resource Type:
    Masters Thesis
    Full Text:
    Oceanographic Conditions on Copepod (Calanus pacificus) Genetic Expression Abstract approved

  • Investigating Transcriptional Control of Specialized Gene Expression in Plants

    Creator:
    Fraser, Valerie N.
    Abstract:
    Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
    Resource Type:
    Dissertation
    Full Text:
    Chromatin, and RNA-seq data to assess gene expression levels. For genes that are differentially

  • Seeing Genes: Multiscale Phenotyping Reveals Gene Functions in Maize Pollen

    Creator:
    Warman, Cedar D.
    Abstract:
    Plant sexual reproduction requires a broad array of molecular mechanisms to proceed successfully. Some of these mechanisms are well-studied, but our knowledge of them as a whole is fundamentally incomplete. Pollen tube growth is a key part of this process, facilitating the delivery of the sperm cells to the female...
    Resource Type:
    Dissertation
    Full Text:
    . Title: Seeing Genes: Multiscale Phenotyping Reveals Gene Functions in Maize Pollen. Abstract

  • Genome Resource Development for Advancement of Corylus avellana Breeding

    Creator:
    Talbot, Samuel Corcoran
    Abstract:
    The European hazelnut (Corylus avellana L.) is a tree nut crop that is important in Oregon, which produces 99% of the United States’ hazelnuts but only 5% of the world’s supply. In order to maintain this market share, farmers in Oregon need cultivars that produce high quality nuts, mature early,...
    Resource Type:
    Masters Thesis
    Full Text:
    revealed differences in the inventory of predicted resistance gene candidates among parental genomes and

  • Hi-C genome assembly of the ectomycorrhizal fungus Rhizopogon salebrosus

    Creator:
    Har, Skyler
    Abstract:
    Rhizopogon salebrosus is an abundant ectomycorrhizal fungus common throughout Western North America that forms mutualistic partnerships with Pinus species. Studied for its systematics, use in sapling nurseries, post-fire seedling establishment, and unique evolutionary history, R. salebrosus holds many secrets within its genome. This thesis aims to characterize the mating system,...
    Resource Type:
    Honors College Thesis
    Full Text:
    contiguous assembly, often leading to heavily inflated genome size and fragmented gene models.5 One

  • Evolutionary Dynamics of Genomes and Endosymbionts in Plant-Parasitic Nematodes

    Creator:
    Wasala, Wasala Mudiyanselage Sulochana K.
    Abstract:
    Plant-parasitic nematodes cause more than US $100 billion in annual agriculture loss worldwide. Thorough knowledge of their genetic diversity, and interactions with endosymbionts and environment have the potential to provide valuable insights into the basic biology of these animals, and assist future efforts aimed at management of these plant parasites....
    Resource Type:
    Dissertation
    Full Text:
    evolution and symbiosis. In chapter 2, a molecular-genetic strategy that targeted the 16S rRNA gene was

  • Gene expression of four carbonic anhydrase paralogs across the symbiotic states of the model temperate sea anemone, Anthopleura elegantissima (Brandt 1835)

    Creator:
    Meier, Emily K.
    Abstract:
    Anthropogenic CO₂ emissions are shifting the global climate equilibrium, causing widespread losses in biodiversity. Anthozoan cnidarians are some of the species most vulnerable to environmental change. Environmental stress causes corals and sea anemones to expel their endosymbiotic algae, which constitute a primary source of nutrition for some Anthozoa. Carbonic anhydrase...
    Resource Type:
    Honors College Thesis
    Full Text:
    related gene segments duplicated and inserted into other parts of the genome, resulting in homologous

  • Using PCR techniques to assess Chlamydia trachomatis genome

    Creator:
    Moo-Fuentes, Jordi C.
    Abstract:
    Chlamydia possesses an immense importance within both human and animal medicine when looking at pathogens. Chlamydia trachomatis infections have been shown to affect both the eye and genital tracts in millions of humans and animals every year [13]. As C. trachomatis strains are highly conserved in patients, it has made...
    Resource Type:
    Honors College Thesis
    Full Text:
    C. trachomatis (460 kb - 560kb) genome. Common DNA sequences across 530 chlamydia genomes were