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Filtering by: Committee Member Mcphail, Kerry Remove constraint Committee Member: Mcphail, Kerry Decade 2020-2029 Remove constraint Decade: 2020-2029

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  • Fungal Secondary Metabolism of Basidiobolus meristosporus: a Novel Natural Product Reservoir

    Creator:
    Trautman, Ian A.
    Abstract:
    Secondary metabolites (SMs) play an integral role in the life history of most fungal species. Fungal metabolomic studies provide insights into how fungi perform certain ecological functions, how they compete and interact with other organisms, and the breadth of fungal chemodiversity. Fungal SMs have also been utilized for a variety...
    Resource Type:
    Masters Thesis
    Full Text:
    as a researcher. To Dr. Kerry McPhail for guiding me through the world of natural products and for

  • Identification of a Bioactive Aryl Ether from a South African Tunicate

    Creator:
    White, Cora L.
    Abstract:
    Chemical compounds produced by organisms, or natural products, are excellent sources of inspiration for anticancer pharmaceutical discovery (Rodrigues et al., 2016). Microtubule targeting agents are a specific class of compounds, often discovered from natural sources, that have been developed as clinically successful anticancer therapies (Steinmetz and Prota, 2018). In the...
    Resource Type:
    Honors College Thesis
    Full Text:
    __________________________________________________________________ Kerry L. McPhail, Committee Member, representing Pharmaceutical Sciences

  • Biogeochemical Processing of Freshwater Carbon in the Anthropocene

    Creator:
    Buser, Jessica Z.
    Abstract:
    Freshwater systems cycle carbon along a spatial and temporal biogeochemical continuum, across which ecosystem processes contribute to transformations of organic matter (OM). Various ecological constraints impact rates OM transformation and production and consumption of the energetic end of respiration, methane. Microbiological processing and complete reduction of carbon substrates to methane...
    Resource Type:
    Dissertation
    Full Text:
    biogeochemist. This includes but is not limited to my committee Byron Crump, Kim Halsey, Laura Lapham, Kerry

  • Detection, biosynthesis, and structural investigations of naturally occurring alkynes and other microbial metabolites

    Creator:
    Back, Daniel C.
    Abstract:
    Natural products have long been an important source of resources for humans. Many of these compounds possess unique chemical structures and potent biological properties. By targeting natural products with specific chemical properties, we can gain a better understanding of the roles these compounds play in the environment and their interactions...
    Resource Type:
    Dissertation
    Full Text:
    . Kerry McPhail and Dr. Aleksandra Sikora, I am thankful for all of the conversations we have shared and

  • Studies on the ecological functions of the antidiabetic drugs acarbose

    Creator:
    Tanoeyadi, Samuel
    Abstract:
    Natural products (a.k.a. secondary metabolites) are produced by living organisms that are not essential for their growth, development, or reproduction, but may play a role in their survival or adaptability in nature. Many secondary metabolites isolated from plants and microbes have found use as molecular probes, drug leads, or medicine...
    Resource Type:
    Masters Thesis
    Full Text:
    through my master’s thesis project. I want to also thank all my committee members, Dr. Kerry McPhail, Dr

  • A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

    Creator:
    Points, Gary L., III
    Abstract:
    Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
    Resource Type:
    Dissertation

  • Non-viral Vectors for Ocular Gene Delivery

    Creator:
    Herrera-Barerra, Marco, F.
    Abstract:
    Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
    Resource Type:
    Dissertation

  • Investigating Transcriptional Control of Specialized Gene Expression in Plants

    Creator:
    Fraser, Valerie N.
    Abstract:
    Specialized or secondary metabolism is a collection of pathways and small molecules that, while beneficial to an organism, are not strictly necessary for survival. Plants use secondary metabolites to, among other things, attract pollinators, defend against biotic and abiotic stressors, and form symbioses. Natural products from plants have seen an...
    Resource Type:
    Dissertation
    Full Text:
    , and Dr. Kerry McPhail—thank you for your personal and professional mentorship and support, as well

  • Biochemical Studies of Pactamycin Biosynthesis in Streptomyces pactum

    Creator:
    Eida, Auday
    Abstract:
    Ribomimetic natural products have long been known for their important biological activities. Structurally, they contain a densely functionalized cyclopentane unit that resembles ribose. Pactamycin, the prominent member of this class of natural products, is a potent protein synthesis inhibitor produced by the soil bacterium Streptomyces pactum. In pactamycin, the aminocyclopentitol...
    Resource Type:
    Dissertation
    Full Text:
    members: Dr. Kerry McPhail, Dr. Benjamin Philmus, Dr. Jane Ishmael, and Dr. Daniel Rocky for their

  • Mass Spectrometry-based Analysis of Superwarfarins and their Metabolites and the Investigation of Novel Treatments for Poisoned Victims

    Creator:
    Nosal, Daniel Grzegorz
    Abstract:
    Superwarfarins are anticoagulant rodenticides that are 100 times more potent and 15 times more persistent than warfarin. They have been used since the 1980s and cause over 10,000 cases of accidental and intentional poisonings per year. Apart from inducing uncontrollable bleeding, by inhibiting the vitamin K cycle, superwarfarins can disrupt...
    Resource Type:
    Dissertation
    Full Text:
    from my graduate committee, Dr. Aleksandra Sikora, Dr. Benjamin Philmus, Dr. Kerry McPhail and Dr