The highly conserved multi-protein mismatch repair (MMR) system is known for its ability to correct post replication errors in genomic DNA. A hallmark of MMR deficiency in all organisms is microsatellite instability. The initiating proteins in the eukaryotic MMR system are hetrodimers formed with an integral MSH2 subunit and one...
Fanconi's Anemia (FA) is an autosomal recessive chromosomal instability disorder. The
symptoms include congenital abnormalities, defective hematopoiesis (formation of cells
of the blood), and high risk of developing acute myeloid leukemia and solid tumors.
Fanconi researchers have long been puzzled by how Fanconi Anemia (FA) cells, which
are known to...
The decisions in Solid Waste Agency of Northern Cook County v. U.S. Army Corps of Engineers, 531 U.S. 159 (2001) (SWANCC) and Rapanos v. United States, 547 U.S. ___(2006), deviated from the more broad interpretations of congressional intent granted by the court in past assessments of the constitutionality of environmental...
Acarapis mites have been present in the United States since 1984 and are presently considered a threat to honey bee populations in North America. They have
been present in Europe since 1921 where infestation rates have now dwindled to a
level that is not considered dangerous. Consequently, accurate information on...
The debate over GM crops is one of the most controversial issues of recent decades. The debate has many dimensions, including environmental impacts, benefits and risks to human health, intellectual property rights, adequacy of biosafety regulations, and fundamental ethical acceptability. The potential benefits of GM crops are numerous, including improved...
We are developing a flavin-containing (Fmo) knock-out mouse for Fmo2 that will be utilized to elucidate the role of active human FMO isoform 2 (FMO2.1) in xenobiotic metabolism and toxicity. Since FMO2 is primarily expressed in lung this will provide information on how 27% of African-Americans and 5% of Hispanics...
The high cost of manually producing background characters creates a demand for a
way to automatically generate plausible behaviors. These background extras need to
behave in a manner that is believable such that they do not distract the focus of the
audience from the primary action occurring in the scene....
In the fall of 2005, I studied abroad in Athens, Greece for one term. This is retelling of experiences that I had, written in the style of my memories. While I was in Greece, I kept an electronic diary, a picture diary, and a scrapbook to keep my memories vivid...
America’s rural Hispanic population is growing at an unprecedented rate. Many of the Hispanic people that are settling in rural communities are immigrants or first generation Americans. If changes to current healthcare systems are required to accommodate the health needs of this growing, low-income rural population they have not been...
The Chlamydiaceae are a family of obligate intracellular bacteria with a unique biphasic developmental cycle. The replicating, metabolically active, intracellular phase bacteria (RBs) grow within a cellular vacuole know as the inclusion. Since the proteins the Chlamydiaceae secrete into this membrane are the means of host/parasite interaction, they have long...
Our research was focused mainly on the field of plasma physics and the creation of plasmas in a laboratory environment. We first began our project with the goal to develop a tabletop Tokamak, a doughnut shaped device that magnetically confines plasmas at pressures greater than one atmosphere. After researching this...
DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
In order to combine my passion for creativity, my love for children, and my engineering background, I decided to create a very personalized thesis project. Princess Catie Goes to College is a children’s book about a young girl whose older sister leaves for college. I chose to write about this...
Surface acoustic wave (SAW) sensors are versatile devices that can be configured to sense a variety of measurands such as temperature and pressure. The potential use of surface acoustic wave devices for magnetic field detection is explored in this study. Compared to current magnetic field sensors, a sensor based on...
Sickle cell disease (SCD) is a phenotypically variable disorder of hemoglobin that leads to abnormally shaped and dysfunctional red blood cells. Several studies have attempted to construct early predictive models for SCD, including Miller et al.’s (2000) model which uses easily identifiable predictors in early life. The primary aim of...
The LifeKnowledge curriculum is a recent initiative of the National FFA Organization to develop key learning precepts in agriculture education students. This material utilizes cutting-edge teaching techniques in lesson plans designed to develop leadership, teamwork, personal development, and communication abilities in students. This project surveyed current agriculture teachers in Oregon...
Massively multiplayer role-playing games (MMORPG) are becoming a popular leisure activity world-wide. MMORPG players have created a new kind of market, one for virtual possessions. Some players will buy and sell virtual goods for real-world money. Many game developers oppose this real-market trade because it threatens the control of their...
Currently, there is no accurate, low-cost method to track divers. Watching bubbles can
give you an approximate xy-location, and expensive underwater radios utilizing ultrasonic waves can work if the diver knows where they are. Traditional radio waves do not work well in water due to the conductive nature of water....
With the miniaturization of microelectronics and increase of processor speeds in the last few decades, thermal management is drastically affecting overall packaging and system capabilities. Due to the special needs introduced, research focusing on microscale cooling has increased. This study combines the positive characteristics of single- and two-phase flows in...
This thesis describes the implementation of an interface for querying established correspondences between anatomical structures across species. I was the main developer of this query engine, called the Comparative Anatomy Information System. My work involved developing methods to query the knowledge base, perform the specified comparison, display the anatomical hierarchies...
Fire blight is a serious disease of apple and pear trees caused by the bacterium, Erwinia amylovora. This bacterium harbors a pathogenesis mechanism known as the Hrp secretory operon which induces some resistance genes and suppresses other resistance genes in the host plant following invasion. While previous researchers analyzed expression...
Media application on the internet has become more and more popular as the bandwidth of the network links increase. The bottleneck of the existing media systems is no longer the link bandwidth at user’s end, but the server’s ability to handle streaming requests. These existing streaming systems do not scale...
High-throughput culturing (HTC) consisting of extinction culturing in autoclaved seawater has led to the isolation and characterization of many novel strains of oligotrophic marine bacteria. Strain HTCC 2207 was isolated from the Oregon coast by the HTC method. Phylogenetic analysis based on 16S rRNA gene sequence showed that this strain...
Wind energy is a cornerstone to the world of renewables. It is widely used in many parts of the world as a clean and effective form of power generation. However, wind power has a number of drawbacks, which limits its use in many regions. Solar power has been used not...
Pacific Northwest Generating Cooperative (PNGC) operates the Landfill Gas to
Energy Facility at Coffin Butte Landfill in Corvallis, OR. At this facility, three internal
combustion engines use the landfill gas (predominantly methane and carbon dioxide) as
fuel to turn generators that produce enough electricity to power 1,800 average sized
homes....
The computer game industry continues to progress toward realistic-looking character motion. However, even in state-of-the-art games, the use of motion capture data in character animation may result in errors such as “foot slipping,” where the feet do not match up with the floor properly during translation. Various algorithms have been...
This thesis explores a three month period that I spent abroad working in medical clinics and hospitals in Ecuador. My work was conducted in three distinct areas: the urban landscape of Quito, Ecuador’s capital; Puyo, a small town bordering the Amazonian rainforest; and a small community located in the heart...
As time continues, the issue of full European Union membership for Norway becomes a more pertinent issue. The EU has long awaited the membership of Norway, but unfortunately the Nordic country has decided to remain independent. Norway’s historical past has led many Norwegians to believe their country is not ready...
Two strains of Escherichia coli were studied to determine the effect of constitutive expression of the SOS DNA damage repair response on the activity of ribonucleotide reductase. Activity of the reductase and cellular deoxynucleoside triphosphate (dNTP) pools were both determined before and after exposure of the cells to ultraviolet radiation....
Un Paseo Encantado, an enchanted walk, is a collection of my observations and experiences in a study abroad program in Oviedo, Spain. My commentary on Spanish culture is based on reading I did prior my departure, in combination with my observations while in Spain. In six chapters, I explore the...
The LIGO interferometers have reached their designed sensitivity level which is greater than any other interferometer ever built. At this point, it is important to have a proper understanding of small perturbations that might still exist (until now these issues did not come to the forefront because other more critical...
Through examination of empirical evidence on individuals with Asperger’s Syndrome and related Pervasive Developmental Disorders, the author attempts to provide an overview of the social deficiencies associated with these disorders. Points of primary concern are the social deficiencies in developing competence in experience-sharing and demonstrating empathy, especially in how they...
Butterfly bush (Buddleja davidii), an ornamental native to China, is an invasive species in Oregon and many other areas. In Oregon, butterfly bush invades disturbed areas, particularly riparian areas. The Oregon nursery industry has the highest farm-gate value of all agricultural commodities and butterfly bush is a significant plant to...
Prostate cancer is the most commonly diagnosed cancer in men, but rates around the world vary greatly. Americans have the highest incidence rates in the world, 4 to 5 times those of Spain. The hypothesis of this thesis was that vitamin D metabolism is a factor in prostate cancer development...
During the 1970’s the United States experienced several periods of high inflation that have been at least partially attributed to positive oil price shocks. The effectiveness of the Organization of Petroleum Exporting Countries at controlling the price of oil has varied over time, as well as the responsiveness of U.S....
ThermoSolver is an educational thermodynamics software program designed to be both
easy to use and useful in that it permits the user to make nontrivial chemical engineering
thermodynamic calculations. The software program accompanies the textbook
Engineering and Chemical Thermodynamics by Milo Koretsky, and is available for free
download from the...
The large population of 2r>100m near earth objects (NEOs) presents a certain hazard to life on earth. It has been proposed that a nuclear device may be used to alter the course of such objects, thereby averting a catastrophic collision with the earth. The asteroid interdiction problem includes a number...
Science is difficult for even its researchers to understand. Science journalists must understand scientific discoveries well enough to write clear, accurate explanations of scientific discoveries for laypeople. A sense of ethical judgment will help journalists ensure that their accounts are reliable and appropriate. Responsible science journalists will maintain a working...
Dental disease is a very prevalent and costly disease in which the symptoms, not the disease, are currently being treated. The disease is caused by pathogenic oral bacteria, many of which are a part of the Mutans Streptococci. The objective of this thesis was to find a natural substance that...
Mangroves are becoming increasingly recognized as important nursery habitats for many juvenile fish and macroinvertebrate species, however little is known about their importance for zooplankton communities. The complex structure of mangrove environments may provide zooplankton populations with shelter, substrate, food, and protection from depredation. These factors could impact zooplankton survival,...
Adverse effects of anti-epileptic (AED) medications on bone density have been reported since the 1960s. Phenytoin and carbamazepine, two commonly prescribed AED, are frequently associated with osteomalacia including fractures and reduced bone formation. The mechanism by which AED induces bone loss is not fully explained. We sought to determine the...