PURPOSE: The in vitro inhibitory effect of Docetaxel (DTX) and Everolimus (EVR) alone and together in
poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) nanocarriers on angiogenic
processes and acute toxicity in mice was evaluated.
METHODS: PEG-b-PLA DTX and/or EVR nanocarriers were characterized for size, drug loading, stability,
and drug release. Cell proliferation, tubule...
A wide variety of organisms show morphologically plastic responses to environmental
stressors but in general these changes are not reversible. Though less common, reversible
morphological structures are shown by a range of species in response to changes in predators,
competitors, or food. Theoretical analysis indicates that reversible plasticity increases fitness...
Information regarding signalment, clinical findings, treatment, and outcome of 5 previously reported cases of anaplastic malignant melanoma of the tail in non-grey horses and of 5 additional cases are summarized. Age was recorded for 9 horses and mean age was 16 years, range 8 to 23 years. Gender was recorded...
We develop the idea of risk transmission from large wildfires and apply network analyses to understand its importance on a 0.75 million ha US national forest. Wildfires in the western US frequently burn over long distances (e.g., 20-50 km) through highly fragmented landscapes with respect to ownership, fuels,
management intensity,...
We use the NCEP/NCAR Reanalysis (NCEP)
and the MPI/ECHAM5 general circulation model to drive
the RegCM3 regional climate model to assess the ability of
the models to reproduce the spatiotemporal aspects of the
Pacific-North American teleconnection (PNA) pattern.
Composite anomalies of the NCEP-driven RegCM3 simulations
for 1982–2000 indicate that the...
Analyzing the socioeconomic impacts of fisheries management requires a distinctive array of information that has so far been less developed than the biological data used in stock assessment. In the case of the European Common Fisheries Policy the project SOCIOEC studies the socioeconomic effects of the new European fisheries management...
Analyzing the socioeconomic impacts of fisheries management requires a distinctive array of information that has so far been less developed than the biological data used in stock assessment. In the case of the European Common Fisheries Policy the project SOCIOEC studies the socioeconomic effects of the new European fisheries management...
Neurospora crassa has been for decades a principal model for filamentous
fungal genetics and physiology as well as for understanding
the mechanism of circadian clocks. Eukaryotic fungal and animal
clocks comprise transcription-translation-based feedback loops that
control rhythmic transcription of a substantial fraction of these transcriptomes,
yielding the changes in protein...
The Jewett Mine is a hard rock mine located on the southern flank of Mount Baldy, approximately 1.6 km from Grants Pass in Josephine County, Oregon on the Grants Pass mining district. The Jewett Group contains 7 separate claims totaling approximately 1.42 km² and consists of several workings including an...
We describe Umbilicaria nodulospora, a distinctive new species occurring on steep rock faces on old lava flows in California and Oregon. The species is unusual among lichenized ascomycetes in consistently having one or two shallowly bulging knobs at one end of each ascospore, suggesting a T, Y, or L shape;...
Non-prescription stimulant use is a high-risk behavior prevalent in the college population. To date, research on this substance use behavior lacks a comprehensive theoretical lens, as well as geographical diversity. Guided by the Theory of Triadic Influence (TTI), multilevel (i.e. students within schools) modeling was used to analyze survey data...
If the spatial and temporal distribution of resources is not homogenous it creates an assignment problem. While the adoption of individual (or transferable) quota management in many commercial fisheries has resolved issues of over-appropriation, assignment problems may remain due to the spatial and temporal complexity of fisheries resources, which creates...
Many experts have argued that the traditional management of commercial fish stocks as single-species is short-sighted, wasteful, and ineffective. Ecosystem-based fisheries management (EBFM) now is being promoted as a potential solution to the problem. While much attention has been directed recently at the potential benefits of implementing EBFM for commercial...
Several behavioral studies have suggested that rarity is critical for enabling irrelevant, salient
objects to capture attention. We tested this hypothesis using the N2pc, thought to reflect
attentional allocation. A cue display was followed by a target display in which participants
identified the letter in a specific color. Experiment 1...
"The need to articulate new ways to manage and utilize marine and fisheries resources has become apparent. The paper outlines the critical importance of managing marine resources for small islands countries of the Pacific and focuses on the role that women can play towards achieving sustainable fisheries.
The paper looks...
Acoustic scattering layers are ubiquitous, horizontally extensive aggregations of both vertebrate and invertebrate organisms that play key roles in oceanic ecosystems. However, currently there are no conventions or widely adaptable automatic methods for identifying these often dynamic, spatially complex features, so it is difficult to consistently and efficiently describe and...
International immersion experiences do not, in themselves, provide students with the opportunity to develop cultural competence. However, using an anthropological lens to educate students allows them to learn how to negotiate cultural differences by removing their own cultural filters and seeing events through the eyes of those who are culturally...
Mt. Hood, in north-central Oregon, has experienced 13 M ≥ 3.0 earthquakes since 1980. 1812 earthquakes that range in magnitude from -1.1 to 4.5 have been recorded in the region during the same time frame. This paper analyzes four of the larger earthquakes to provide moment tensor solutions and relocated...
Condors and vultures comprise the only group of terrestrial vertebrates in the world that are
obligate scavengers, and these species move widely to locate ephemeral, unpredictable, and patchily-distributed
food resources. In this study, we used high-resolution GPS location data to quantify
monthly home range size of the critically endangered California...
Since October 2013, consecutive cases of food mislabeling, such as Black Tiger Prawns being sold under the name of Kuruma Prawns in famous restaurants, department stores, etc., have begun to surface in Japan, and this has become a social problem. This study conducted a consumer questionnaire in free-answer format in...
Feedback loops involving soil microorganisms can
regulate plant populations. Here, we hypothesize that microorganisms
are most likely to play a role in plant–soil feedback
loops when they possess an affinity for a particular plant and
the capacity to consistently affect the growth of that plant for
good or ill. We...
Amplification was regarded, since the early days of quantum theory, as a mysterious ingredient that
endows quantum microstates with macroscopic consequences, key to the “collapse of the wave packet,”
and a way to avoid embarrassing problems exemplified by Schrödinger’s cat. Such a bridge between the
quantum microworld and the classical...
Despite the considerable advances of deposition technologies, it remains a significant challenge to form conformal deposition on surface of nanoporous carbons. Here, we introduce a new ambient hydrolysis deposition method that employs and controls pre-adsorbed water vapor on nanoporous carbons to define the deposition of TiO₂. We converted the deposited...
Alkali or acid-induced structural modifications in β-chitin from squid (Dosidicus gigas, d'Orbigny, 1835) pens and its moisture absorption ability (MAA) and deacetylating reaction were investigated and compared with α-chitin from shrimp shells. β-chitin was converted into α-form after 3 h in 40% NaOH or 1-3 h in 40% HCl solution,...
The present study extended existing research on alexithymia in men, investigating whether the deficit in processing emotions occurs early in the process, as a result of dissociation or repression, or later, as a result of suppression. We also examined the assumption in Levant’s (2011) normative male alexithymia hypothesis that men...
The life cycles of three Madden–Julian oscillation (MJO) events were observed over the Indian Ocean as part of the Dynamics of the MJO (DYNAMO) experiment. During November 2011 near 0°, 80°E, the site of the research vessel Roger Revelle, the authors observed intense multiscale interactions within an MJO convective envelope,...
Combined analyses of deep tow magnetic anomalies and International Ocean Discovery Program Expedition 349 cores show that initial seafloor spreading started around 33 Ma in the northeastern South China Sea (SCS), but varied slightly by 1-2 Myr along the northern continent-ocean boundary (COB). A southward ridge jump of ∼20 km...
Cisplatin (CDDP) is a highly active platinum-containing chemotherapeutic agent for use against solid tumors, including ovarian. However, like most antitumor agents, CDDP use is accompanied by non-tumor tissue toxicities leading to unwanted side effects, including neuropathy. To date, the mechanism(s) for these side effects are undefined. However, the clinical features...
We show how a distributed borehole flowmeter can be created from armored Fiber Optic
cables with the Active-Distributed Temperature Sensing (A-DTS) method. The principle is that in a flowing
fluid, the difference in temperature between a heated and unheated cable is a function of the fluid velocity.
We outline the...
Using a short-baseline hydrophone array, persistent volcanoacoustic sources are identified within the ambient noise field of the Lau Basin during the period between 2009 January and 2010 April. The submarine volcano West Mata and adjacent volcanic terrains, including the northern Matas and Volcano O, are the most active acoustic sources...
Contamination of newly planted bermudagrass (Cynodon spp.) varieties by undesirable off-type bermudagrass genotypes is an
ever increasing concern for turf managers because selective control options are limited. In 2009, a sethoxydim {2-[1-(ethoxyimino)butyl]-5-[2-(ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-one} tolerant bermudagrass genotype (93-175) was identified during
herbicide screening at the University of Georgia in Tifton. The objective...
The accuracy of state-of-the-art global barotropic tide models is assessed using bottom
pressure data, coastal tide gauges, satellite altimetry, various geodetic data on Antarctic ice shelves, and
independent tracked satellite orbit perturbations. Tide models under review include empirical, purely
hydrodynamic (“forward”), and assimilative dynamical, i.e., constrained by observations. Ten dominant...
The chemical kinetics ODEs arising from operator-split reactive-flow simulations were solved on GPUs using explicit integration algorithms. Nonstiff chemical kinetics of a hydrogen oxidation mechanism (9 species and 38 irreversible reactions) were computed using the explicit fifth-order Runge–Kutta–Cash–Karp method, and the GPU-accelerated version performed faster than single- and six-core CPU...
Cosmogenic-burial and U-series dating, identification of fluvial terraces and lacustrine
deposits, and river-profile reconstructions show that capture of the Gunnison River by
the Colorado River and abandonment of Unaweep Canyon occurred between 1.4-0.8
Ma. This event led to a rapid pulse of incision unlike any documented in the Rocky
Mountains....
We demonstrate a versatile and efficient setup to perform femtosecond stimulated Raman spectroscopy (FSRS). Technical innovations are implemented to achieve the wavelength tunability for both the picosecond narrowband Raman pump pulse and femtosecond broadband Raman probe pulse. Using a simplified one-grating scheme in a home-built second harmonic bandwidth compressor followed...
Pantar Island's coastal communities like many other coastal communities in eastern Indonesia have a high dependency on marine resources for income, food security and other benefits. Fish products (comprising several species of demersal and pelagic species) are particularly valuable (in addition to other products harvested and traded for export markets)...
This article presents the results of a high-resolution (1/12°), two-way nested simulation of the
oceanic circulation in the southwestern Atlantic region. A comparison between the model results and
extant observations indicates that the nested model has skill in reproducing the best-known aspects of the
regional circulation, e.g., the volume transport...
The fission Time Projection Chamber (fissionTPC) is a compact (15 cm diameter) two-chamber
MICROMEGAS TPC designed to make precision cross-section measurements of neutron-induced fission.
The actinide targets are placed on the central cathode and irradiated with a neutron beam that passes
axially through the TPC inducing fission in the target....
We examined 480 dissertations on the use of technology in mathematics education and developed a Quality Framework (QF) that provided structure to consistently define and measure quality. Dissertation studies earned an average of 64.4% of the possible quality points across all methodology types compared to studies in journals that averaged...
Self-management has been recognized as important in successfully governing the common pool resources. This is no exception in fishery. Fishery cooperatives, where fishermen collectively manage the fishery, are garnering much attention from both regulators and academics. In this study, we aim to empirically disentangle the efficiency mechanism of pooling system....
A new genus and species of Snail-killing flies, Dominimyza tanyacaena, n. gen., n. sp. (Diptera: Sciomyzidae) is described from Dominican amber. Diagnostic characters for Dominimyza include a propleuron with a strong bristle, an elongate porrect flagellum with a long, finely pubescent arista, divergent ocellar, post-ocellar and outer vertical bristles, convergent...
In an open fishery, the competition for the limited fish stock can lead fishermen to a ``race for fish" with sub-optimally high capital investments. Buyback programs to reduce excess capacity in national fisheries have been often used, but seldom successful. Where they have successfully reduced excess capacity, the programs have...
Projections of a drier, warmer climate in the U.S. Southwest would complicate
management of the Colorado River system – yet these projections, often based on coarse
resolution global climate models, are quite uncertain. We present an approach to understanding
future Colorado River discharge based on land surface characterizations that map...
From December 2006 to November 2011, the Pacific Northwest Seismic Network (PNSN)
reported 467 earthquakes in a swarm 60 km east of Mt Hood near the town of Maupin, Oregon.
The swarm included 20 M[subscript D] ≥ 3.0 events, which account for over 80 per cent of the cumulative
seismic...
We review how urbanization alters aquatic ecosystems, as well as actions that managers can take to remediate urban waters. Urbanization affects streams by fundamentally altering longitudinal and lateral processes that in turn alter hydrology, habitat, and water chemistry; these effects create physical and chemical stressors that in turn affect the...
A substantial body of evidence has correlated the human body burdens of some polybrominated diphenyl ether (PBDE) flame retardants with cognitive and other behavioral deficits. Adult zebrafish exhibit testable learning and memory, making them an increasingly attractive model for neurotoxicology. Our goal was to develop a rapid throughput means of...
Australian governments spend millions of dollars each year on pre-border, border and post-border biosecurity programs. The majority of these programs are resourced through existing deeds of agreement, but some currently fall outside of these funding frameworks. Frameworks not based on economic principles have the potential to deliver sub-optimal outcomes with...
Recently, Duke and Jenkins have studied a certain family of modular forms fk,m, that form a natural basis of the space of weakly holomorphic modular forms of weight k on SL2(Z). In particular, they prove that for all but at most [k/12] + 1 values of m, the zeros of...