Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
The Bcl-2 family of proteins regulate cell survival and are targets for cancer therapy. This protein family has also been implicated in chemotherapeutic resistance, the cause of approximately 90% of treatment failure in advanced cancer. We analyzed the expression and the role of the Bcl-2 proteins in chemotherapy resistant breast...
Current protein immobilization techniques lack defined control over protein orientation. Protein orientation is important for making biosensors and biomaterials that are sensitive and efficient and can be crucial for designing some devices such as immunosensors or direct electron transferring biocells. A new method of protein immobilization is proposed that takes...
While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...