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  • Certain physiological and pharmacological effects of radiation on rabbits

    Creator:
    Wagelie, Edwin Gan
    Abstract:
    Data were taken, following irradiation exposure to 100r and 300r cumulative dose, on 89 rabbits of three breeds that vary greatly in body size. Hematological, intestinal motility, and ear vascularity examinations were performed. Least square estimates have been obtained and an analysis of variance has been conducted in order estimate...
    Resource Type:
    Dissertation
    Full Text:
    Certain Physiological and Pharmacological Effects of

  • A metabolic function of selenium, assessed with rat liver homogenates

    Creator:
    Bull, Richard Charles
    Abstract:
    In three separate trials rats were fed either a basal diet deficient in selenium and vitamin E or the same diet supplemented with one or both of these factors. In addition to these treatments in two of the trials, ethoxyquin was included to provide adequate lipid antioxidant protection and to...
    Resource Type:
    Dissertation
    Full Text:
    beneficial effect upon reproduction in the rat. Somewhat later Poley et al. (1941), also conducting a

  • Influence of dietary selenium on the distribution of tritium-labeled vitamin E in the rate

    Creator:
    Cheeke, Peter R.
    Abstract:
    A series of four trials were conducted to determine the influence of selenium supplementation of a selenium- and vitamin E-deficient basal diet on the absorption, excretion, tissue distribution and placental transfer of a single dose of tritium-labeled α-tocopherol in the rat. In the first trial, the effect of supplementation of...
    Resource Type:
    Dissertation
    Full Text:
    the rat. In the first trial, the effect of supplementation of the basal diet with 1. 0 ppm selenium

  • The effect of selenium on chemical carcinogenicity in the rat

    Creator:
    Johnston, Weldon Kearney
    Abstract:
    One hundred and fifty-one weanling rats of both sexes were fed control diets or diets containing 160 ppm diethylnitrosamine (DEN) or 150 ppm N-2-fluorenyl-acetamide (FAA). The carcinogen level was calculated so that the LD₅₀ should be achieved at about 17 weeks. Each carcinogen treatment was incorporated with three different diet...
    Resource Type:
    Masters Thesis
    Full Text:
    The Effect of Selenium on Chemical Carcinogenicity in the

  • Selenium effects and species differences in hepatic metabolism of pyrrolizidine alkaloids and other xenobiotics

    Creator:
    Shull, Lee R.
    Abstract:
    The metabolism of pyrrolizidine alkaloids and other drugs was studied with regard to nutritional status and species differences. Pyrrolizidine alkaloids which are biotransformed to severely toxic metabolites were isolated from tansy ragwort (Senecio jacobaea). Semi-purified alkaloid crystals containing five alkaloids (senecionine, seneciophylline, jacobine, jacoline, and jacozine) were prepared and found...
    Resource Type:
    Dissertation
    Full Text:
    liver weight, but had no effect on microsomal oxidases. Similarly, high copper had no effect on the

  • Some aspects of the mechanism of estrogen action in the uterus of the ewe

    Creator:
    Koligian, Karl Bruce
    Abstract:
    The binding of estrogen to endometrium and uterine arteries of the ewe was investigated by use of a [³H]estradiol exchange assay and by incubating whole tissue aliquants with [³ H]estradiol, a method which permits quantification of bound estrogen translocated from the cytoplasm to the nucleus. Five ewes were necropsied on...
    Resource Type:
    Dissertation
    Full Text:
    arteries on day 10 only. The effect of estrogen and progesterone on concentra- tions of estrogen

  • The influence of selenium on selenoprotein W

    Creator:
    Yeh, Jan-ying
    Abstract:
    The objective of our study was to investigate the effect of selenium on selenoprotein W. Western blot analysis indicated that selenoprotein W is present in muscle, brain, testis and spleen of rat tissues. Tissue distribution of selenoprotein W was not altered in rats fed various selenium levels. Among muscle, brain,...
    Resource Type:
    Dissertation
    Full Text:
    . Whanger The objective of our study was to investigate the effect of selenium on selenoprotein W

  • Purification and characterization of recombinant calpain-5

    Creator:
    Wang, Mei-Chuan
    Abstract:
    Recombinant human calpain-5 was expressed in insect cells using a baculovirus system. The expressed calpain-5 was purified by both traditional chromatography and by affinity-column chromatography. Both methods yielded active protease. Calpain-5 displayed very limited hydrophobicity. This indicated that calpain-5 is not a membrane binding protein. Calpain-5 had pI of 8.3....
    Resource Type:
    Dissertation
    Full Text:
    cysteine proteases. Although the exact physiological roles of calpains remain to be elucidated, calpains

  • Influence of certain chemicals on the sensitivity of rat embryos to X-irradiation

    Creator:
    Loawhakasetr, Pathom
    Abstract:
    The effect of 2-aminoethyl-2-thiopseudourea[superscript .]Br[superscript .]HBr (AET), 2-mercaptoethylamine[superscript .]HC1 (MEA) and trisodium calcium chelate of diethylenetriaminepentaacetic acid (CaNa₃DTPA) on the radiosensitivity of rat fetus was investigated. A total of 1256 fetuses were critically examined. Exposure of rats to 200 r whole-body X-irradiation at 9.5 days of gestation resulted in a...
    Resource Type:
    Dissertation
    Full Text:
    CERTAIN CHEMICALS ON THE SENSITIVITY OF RAT EMBRYOS TO X-IRRADIATION Abstract approved The effect of

  • The effect of the copper intake on the flavor and storage life of meat products

    Creator:
    Idris, Omer Fadle
    Abstract:
    The susceptibility of milk to copper-induced or accelerated off-flavors is well known. Other animal products, including meats have not been so extensively studied. In this study different species of animals (pigs, calves, lambs and rabbits) were fed on normal rations with and without supplements of copper sulfate. During the course...
    Resource Type:
    Masters Thesis
    Full Text:
    - rnents urr:dur:ed a.ny sig:i.ificant effect on rneat; flav,:rs. t/ 1M^3o, lrrofe ,y6r'1 t { T ll i:t