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Filtering by: Creator Stegmann, P. M. Remove constraint Creator: Stegmann, P. M. Degree Field Biochemistry and Biophysics Remove constraint Degree Field: Biochemistry and Biophysics File Format application/msword Remove constraint File Format: application/msword

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  • The role of CYP2E1 and CYP4A in the development of non-alcoholic steatohepatitis

    Creator:
    Hawkins, Jenna M.
    Abstract:
    Non-alcoholic Steatohepatitis (NASH) is an emerging form of liver disease associated with obesity, type II diabetes and dyslipidemia. As the prevalence of these metabolic conditions increases, so too has the occurrence of NASH in all sectors of the population. The pathology of this disease is similar to its alcoholic form,...
    Resource Type:
    Honors College Thesis
    Full Text:
    Genotype Gender Age Metabolic State WT F 10 weeks lean WT M 9 weeks lean CamK-cre M 10 weeks lean

  • Investigating the age-related loss of endoplasmic reticulum stress response

    Creator:
    Fallahi, Anahita
    Abstract:
    The endoplasmic reticulum (ER) is a crucial organelle in the cell where protein folding and processing occurs, and conditions that negatively affect ER functions are highly detrimental to the cell. The accumulation of unfolded/misfolded proteins in the ER leads to a condition known as ER Stress. The ER has developed...
    Resource Type:
    Honors College Thesis
    Full Text:
    . 15 m R N A C H O P/ β- A ct in Young Old N.S . ** * N.S . N.S . * 0 4 12 24

  • Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

    Creator:
    O'Donnell, Edmond Francis
    Abstract:
    DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
    Resource Type:
    Honors College Thesis
    Full Text:
    Immunohistochemistry m- Mouse MEF Mouse embryonic fibroblast MLH MutL homolog MMR Mismatch Repair MSH MutS

  • Aging and oxidative damage to mitochondrial membrane proteins

    Creator:
    Tong, Tony T.
    Abstract:
    Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
    Resource Type:
    Honors College Thesis
    Full Text:
    , Accessed Dec 15, 2006. 9. H. Steen and M. Mann, Nature reviews, 2004, 5, 699-711. 10. P. Roepstorff and J

  • Investigating the Role of the MutLα Endonuclease

    Creator:
    Mankaney, Gautam Naresh
    Abstract:
    Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
    Resource Type:
    Honors College Thesis
    Full Text:
    proteins were transferred to Immobilon-P PVDF membrane (Millipore, Danvers, PA) in a Criterion transfer

  • Generation of proof of concept molecules neutralizing monoclonal antibodies to IL17Cm

    Creator:
    Calhoun, Drew W.
    Abstract:
    Inflammation is one of the first, most important responses of the immune system when presented with infection and is mediated primarily by eicosanoids and cytokines. The goal of this research was to generate monoclonal antibodies against murine IL17C, a poorly characterized cytokine involved in inflammation and linked to inflammatory conditions....
    Resource Type:
    Honors College Thesis
    Full Text:
    2.6 Non-blocking Antibodies Screen (Detection: G α-M IgG Fc-specific-HRP)…...36 Graph 1. Mouse