Index Catalog // ScholarsArchive@OSU

Oligoribonucleotides directed at ribosomal protein binding sites as inhibitors of ribosomal small subunit assembly and as possible antibiotics

Creator:: Thompson, Cynthia Sue
Abstract:: The effects of oligoribonucleotides of identical or similar sequences to a ribosomal protein binding site, specifically S8, on prokaryotic 30S ribosomal assembly were investigated in Escherichia coli. The oligoribonucleotides were expected to bind to the target protein S8 and block its incorporation into the 30S subunit, resulting in a nonfunctional...
Resource Type:: Dissertation
Full Text:: THESIS OF Cynthia Sue Thompson for the degree of Doctor of Philosophy in Biochemistry and Biophysics

The binding of ethidium bromide to chromatin : model for carcinogen interactions

Creator:: McMurray, Cynthia T.
Abstract:: Five forms of chromatin, which represent the in vivo folded forms of nucleic acid, were isolated and used as the binding substrate for model intercalating compound, ethidium bromide. For all forms of chromatin, the affinity, location and structural effects of binding were examined. On the level of the nucleosome, the...
Resource Type:: Dissertation
Full Text:: carcinogen interactions AN ABSTRACT OF THE THESIS OF Cynthia T. McMurray for the degree of Doctor of

Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

Creator:: Hendricks, Stephen P.
Abstract:: The first committed step in DNA biosynthesis occurs by direct reduction of ribonucleotides. This reduction is catalyzed by ribonucleotide reductase (RNR), an enzyme which uses a unique radical mechanism to facilitate the transformation. All four DNA precursors are synthesized by a single enzyme. Therefore, an intricate pattern of regulation has...
Resource Type:: Dissertation
Full Text:: Activities. Abstract approved: Christopher K. Mathews The first committed step in DNA biosynthesis

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Lillian K

Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor

Creator:: Vogel, Walter Kevin
Resource Type:: Dissertation
Full Text:: thank Christopher K. Mathews, George J. Mpitsos, Thomas F. Murray, and Kensal E. van Holde for serving

Prothoracicotropic hormone, cyclic nucleotides, and proctolin in insect central nervous system

Creator:: Kingan, Timothy Gilmore
Abstract:: Prothoracicotropic hormone has been partially purified from whole heads of tobacco hornworm larvae, Manduca sexta. Activity was followed with a larval bioassay. Activity was purified 4400 fold from crude extracts. The hormone was found to be a heat-stable polypeptide with an approximate molecular weight of 25,000 Daltons. The hormone has...
Resource Type:: Dissertation
Full Text:: of the 'status-quo' or 'juvenile hormone' from abdomens of male H. cecropia and Samia cynthia moths

Functional domains of Agrobacterium tumefaciens single-stranded DNA binding protein VirE2

Creator:: Dombek, Priscilla Emily
Abstract:: Agrobacterium tumefaciens is a gram-negative soil bacterium that causes crown gall tumors on dicotyledenous plants. The transferred DNA (T-DNA) portion of the A. tumefaciens tumor-inducing (Ti) plasmid enters infected plant cells and integrates into plant nuclear DNA. The T-DNA is accompanied into plant cells by the VirD2 endonuclease covalently attached...
Resource Type:: Dissertation
Full Text:: discs, carrot, K. daigremontiana and tomato. 124 223 LIST OF APPENDIX FIGURES A.1.1

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:: Nian, Hui
Abstract:: Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
Resource Type:: Dissertation

Towards the understanding of the function of the histone "tails" with respect to the structure, stability, and function of chromatin

Creator:: Dong, Feng
Abstract:: By using immobilized trypsin, I have been able to prepare well-defined, stable trypsinized nucleosomes. The difficulties of lacking of control in the extent of trypsinization, which were encountered in previous studies with the use of free trypsin, have been eliminated. The nucleosomes and oligonucleosomes prepared by immobilized trypsin are suitable...
Resource Type:: Dissertation
Full Text:: projects. I would also like to thank the members in our research group -- including Drs. Cynthia McMurray

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Creator:: Hall, Justin Daniel
Abstract:: Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
Resource Type:: Dissertation
Full Text:: patience, Cynthia Lynn Todd for gentle steerage; Sean Hall, for helping me laugh and keep perspective

ScholarsArchive@OSU

Oligoribonucleotides directed at ribosomal protein binding sites as inhibitors of ribosomal small subunit assembly and as possible antibiotics

The binding of ethidium bromide to chromatin : model for carcinogen interactions

Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Site-directed mutagenesis of the m2 muscarinic acetylcholine receptor

Prothoracicotropic hormone, cyclic nucleotides, and proctolin in insect central nervous system

Functional domains of Agrobacterium tumefaciens single-stranded DNA binding protein VirE2

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Towards the understanding of the function of the histone "tails" with respect to the structure, stability, and function of chromatin

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Date

Decade

Degree Field

Degree Level

Degree Name

Language

License

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search