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  • Activation and Nuclear Translocation of the Transcription Factor Nrf2 by the MAP Kinase Family

    Creator:
    Nguyen, Ngan H.
    Abstract:
    Eukaryotic cells have developed elaborate biochemical processes to counteract oxidative stress, electrophiles, or carcinogens due to environmental insults. One of these important cellular defense mechanisms is mediated by the transcription factor Nrf2 that have been shown to have decrease activity with age. While the process of which Nrf2 is involved...
    Resource Type:
    Honors College Thesis
    Full Text:
    of Graphs Graph Page 1. Testing effect of APAP and Menadione on Nrf2 nuclear localization…. 10

  • Calpain 2 Cleavage of Akt in Glioblastoma Multiforme

    Creator:
    Zhang, Justin
    Abstract:
    Glioblastoma is a malignant brain tumor that has extremely poor prognoses with a 5 year survival rate of less than 5%. The low survival rates of glioblastoma patients is attributed to glioblastoma cells being extremely resistant to radiotherapy and chemotherapy as well as being very invasive. We previously identified calpain...
    Resource Type:
    Honors College Thesis
    Full Text:
    signal in the peri nuclear region as well as at the specific sites of the membrane. Staining of F-actin

  • A taxonomy of biomolecular features

    Creator:
    North, Jacob L.
    Abstract:
    The scientific method applies hypothesis testing to material samples through experimentation, measurement, and data analysis, which produce representations—or features—that describe phenomena of interest. Biomolecular features come in numerous forms such as values, matrices, graphs, three-dimensional structures, trajectories, and molecular surfaces. Researchers have tested thousands of features related to protein molecules...
    Resource Type:
    Honors College Thesis
    Full Text:
    illuminate nat- ural phenomena, including a broad range of material properties. Engineers then apply these

  • Selection of an Orthogonal tRNA Synthetase for Trifluoromethyl-phenylalanine in Methanomethylophilus Alvus System

    Creator:
    Eyberg, Daniel R.
    Abstract:
    Genetic code expansion is a technology that allows for site-specific incorporation of noncanonical amino acids into recombinant proteins at amber stop codons using engineered translational machinery. The technology allows for expanded study into proteins, derived from the integration of novel chemical functions found in noncanonical amino acids, such as fluorescence,...
    Resource Type:
    Honors College Thesis
    Full Text:
    resolution.6 The method targets the resonance frequencies of atoms given by their nuclear spins

  • Ke Truyen Ma : Vietnamese Refugees Altering The Course of U.S. History, Kể Truyện Ma : Vietnamese Refugees Altering The Course of U.S. History

    Creator:
    Nguyen, Hai Yen T.
    Abstract:
    Since the 1960s, Vietnamese scholars have written autobiographical literature catered to the American public though they have not gotten as much recognition as soldier accounts and anti-war literature. These Vietnamese literatures shifted in scope and form with the succeeding waves of refugee resulted from the war in Việt Nam. As...
    Resource Type:
    Honors College Thesis
    Full Text:
    Vietnam War, 1962-64: The Vietnamese Communist Perspective,” Journal of Contemporary History 35, no. 4

  • Nongenomic Actions of Steroid Hormones in the Ovine Endometrium

    Creator:
    Ireton, Kyle E.
    Abstract:
    The steroid hormone estrogen plays a crucial role in regulating certain mammalian tissues, especially female reproductive systems. Estrogen effects physiological changes in the cell by altering transcription activity for certain target genes, as a consequence of interactions between estradiol-17β (E2) and its nuclear receptor (nER). This mechanism of cellular control...
    Resource Type:
    Honors College Thesis
    Full Text:
    nuclear receptor (nER). This mechanism of cellular control is referred to as classical genomic

  • Investigating the age-related loss of endoplasmic reticulum stress response

    Creator:
    Fallahi, Anahita
    Abstract:
    The endoplasmic reticulum (ER) is a crucial organelle in the cell where protein folding and processing occurs, and conditions that negatively affect ER functions are highly detrimental to the cell. The accumulation of unfolded/misfolded proteins in the ER leads to a condition known as ER Stress. The ER has developed...
    Resource Type:
    Honors College Thesis
    Full Text:
    responses (Oyadomari, 2004). Another target of the PERK kinase is the transcription factor nuclear

  • Involvement of PP6 in Dephosphorylation of Bcl11b, a Tumor Suppressor Transcription Factor

    Creator:
    Parker, Chelsea R.
    Abstract:
    The purpose of this honors thesis research project is to investigate the molecular causes of childhood and infant T-cell acute lymphoblastic leukemias. T-cells are the work horses of the immune system, and like any organ, must develop properly to be fully functional. Improper development of thymocytes into T-cells can lead...
    Resource Type:
    Honors College Thesis
    Full Text:
    Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors.” Journal of

  • Generation of proof of concept molecules neutralizing monoclonal antibodies to IL17Cm

    Creator:
    Calhoun, Drew W.
    Abstract:
    Inflammation is one of the first, most important responses of the immune system when presented with infection and is mediated primarily by eicosanoids and cytokines. The goal of this research was to generate monoclonal antibodies against murine IL17C, a poorly characterized cytokine involved in inflammation and linked to inflammatory conditions....
    Resource Type:
    Honors College Thesis
    Full Text:
    . Materials & Methods Immunization The production of anti-IL17Cm monoclonal antibodies began with the

  • Characterization of Fer1L6 in the mouse C2C12 cell line

    Creator:
    Huegel, Jacob T.
    Abstract:
    Fer1L6 is an uncharacterized member of the ferlin family of proteins, a group of large, calcium sensitive proteins with emerging roles in vesicle trafficking and various disease states. The presence of Fer1L6 has been identified within the C2C12 cell line of mouse skeletal muscle. To determine the protein’s subcellular location...
    Resource Type:
    Honors College Thesis
    Full Text:
    career. TABLE OF CONTENTS INTRODUCTION ………………………………………………………………………1. MATERIALS AND