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Filtering by: Creator Wong, Carmen P. Remove constraint Creator: Wong, Carmen P. Degree Field Biochemistry and Biophysics Remove constraint Degree Field: Biochemistry and Biophysics Resource Type Honors College Thesis Remove constraint Resource Type: Honors College Thesis

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  • Peptide Non-planarity Regained

    Creator:
    Biel, Justin T.
    Abstract:
    The planar peptide model has guided our understanding and interpretation of protein crystal structures since its origin in the 1950s. It is well understood that deviations from this model occur, but the majority of peptides are planar, as measured by the standard omega torsion angle. Here, we report the first...
    Resource Type:
    Honors College Thesis
    Full Text:
    : ________________________________________ P. Andrew Karplus

  • Voluntary alcohol consumption in male rhesus macaques suppresses cancellous bone remodeling

    Creator:
    Kahler-Quesada, Arianna M.
    Abstract:
    Background: Chronic heavy alcohol consumption is a risk factor for bone fracture. Using a non-human primate model of voluntary alcohol self-administration, we have recently shown that alcohol consumption suppresses intracortical bone remodeling. The current study extends this investigation to asses the effect of alcohol consumption on cancellous bone mass, architecture,...
    Resource Type:
    Honors College Thesis
    Full Text:
    Sciences _____________________________________________________________________ Carmen Wong, Committee

  • Investigating the age-related loss of endoplasmic reticulum stress response

    Creator:
    Fallahi, Anahita
    Abstract:
    The endoplasmic reticulum (ER) is a crucial organelle in the cell where protein folding and processing occurs, and conditions that negatively affect ER functions are highly detrimental to the cell. The accumulation of unfolded/misfolded proteins in the ER leads to a condition known as ER Stress. The ER has developed...
    Resource Type:
    Honors College Thesis
    Full Text:
    the post mitotic SV A31 cells (Larsson, 1993). The same year, Wong, et al, treated GH3 cells with

  • Effects of 6 months of voluntary alcohol self-administration on intracorticalbone remodeling in young adult male cynomolgus monkeys

    Creator:
    Kuah, Amida F.
    Abstract:
    Heavy chronic alcohol consumption has been linked to a myriad of detrimental skeletal effects. Many studies have been conducted to examine the effects of alcohol abuse upon cancellous bone. However, little is known about its effect upon cortical bone. The skeleton is comprised of approximately 80% cortical bone and thus...
    Resource Type:
    Honors College Thesis
    Full Text:
    ., Smoking and bone metabolism in elderly women. Bone, 2000. 27(3): p. 429-36. 6. Wong, P.K., J.J

  • The Cathelicidin Anti-microbial peptide gene alters the mouse gut microbiome

    Creator:
    Rouches, Miles V.
    Abstract:
    The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
    Resource Type:
    Honors College Thesis
    Full Text:
    abundance, its absence in the knockout mice resulted in significantly lower phylogenetic diversity (p

  • Investigation of autophagy-assisted cell death in response to the cancer cell toxin coibamide A

    Creator:
    Tan, Michelle
    Abstract:
    Autophagy, a homeostatic degradation pathway, has a role in promoting cell survival under stress conditions, but can also promote cell death under conditions of sustained stress. This project investigates the cytotoxic potential of coibamide A and other natural products in autophagy-deficient and wild-type mouse embryonic fibroblasts (MEFs). Wild-type MEFs were...
    Resource Type:
    Honors College Thesis
    Full Text:
    ., Wong, P. M., Gammoh, N., & Jiang, X. (2011). Distinct autophagosomal- lysosomal fusion mechanism

  • Impaired epidermal homeostasis in Bcl11bR3S/R3S homozygous mutant mice

    Creator:
    Kelly, Avalon G.
    Abstract:
    BCL11B, also known as CTIP2, is a transcription factor which plays a critical role in the regulation and development of many tissues and organ systems, including the skin. A 2019 study by Goos et. al. uncovered a novel point mutation in BCL11B gene that converted the Arginine(R)-3 residue to a...
    Resource Type:
    Honors College Thesis
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    significantly decreased epidermal thickness in comparison with the wildtype (p<0.05, unpaired two-tailed t

  • Thermodynamic Design Principles for Double-Strand Displacement microRNA Biosensors

    Creator:
    Smith, Natasha M.
    Abstract:
    In recent years, microRNA’s (miRNA’s) have emerged as important in regulating gene expression. Fluctuations in their levels are associated with the up or down-regulation of tumor-suppressor genes and oncogenes. Thus, the ability to visualize changes in miRNA is an important step in understanding cancer emergence and development. The Burrows group...
    Resource Type:
    Honors College Thesis
    Full Text:
    Web Server. The probability (p) of each nucleotide as bound or free is indicated by the following

  • Adding value to renewable biodiesel production from the oleaginous yeast Lipomyces starkeyi

    Creator:
    Brosy, Jack R.
    Abstract:
    Global warming and on-going depletion of fossil fuels have stimulated research to develop renewable sources of energy. Current renewable energy use comprises only 10% of the energy consumed in the US and is focused mostly on generating electricity. The majority of the energy consumed by the US transportation sector is...
    Resource Type:
    Honors College Thesis
    Full Text:
    C20:0 C22:0 C24:0 P er ce n t o f Fa tt y A ci d s Fatty Acid Composition YEPD-grown