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Filtering by: Creator Becker, Kevin G. Remove constraint Creator: Becker, Kevin G. Degree Field Biochemistry and Biophysics Remove constraint Degree Field: Biochemistry and Biophysics

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  • Activation of Co-stimulatory Molecule OX40 Increases Memory T-cell Function and Cytokine Production in Uveitis

    Creator:
    Hall, Mark
    Abstract:
    Uveitis is a serious ophthalmological disorder characterized by intraocular infiltration of inflammatory cells. In most cases, uveitis is derived from the adaptive immune response. More specifically, CD4+ T lymphocytes play an important role in the pathogenesis of uveitis by recognizing uveitogenic antigen and orchestrating the immune response. While it is...
    Resource Type:
    Honors College Thesis
    Full Text:
    : _________________________________________ Kevin Ahern Uveitis is a serious

  • Validation of early predictors of outcome in the Dallas Newborn Cohort

    Creator:
    Lee, Nancy Jade
    Abstract:
    Sickle cell disease (SCD) is a phenotypically variable disorder of hemoglobin that leads to abnormally shaped and dysfunctional red blood cells. Several studies have attempted to construct early predictive models for SCD, including Miller et al.’s (2000) model which uses easily identifiable predictors in early life. The primary aim of...
    Resource Type:
    Honors College Thesis

  • Generation of proof of concept molecules neutralizing monoclonal antibodies to IL17Cm

    Creator:
    Calhoun, Drew W.
    Abstract:
    Inflammation is one of the first, most important responses of the immune system when presented with infection and is mediated primarily by eicosanoids and cytokines. The goal of this research was to generate monoclonal antibodies against murine IL17C, a poorly characterized cytokine involved in inflammation and linked to inflammatory conditions....
    Resource Type:
    Honors College Thesis
    Full Text:
    Kevin Ahern Inflammation is one of the first, most important responses of the immune system when

  • Permeability of Various Thyroid Hormone Derivatives and Discovery of a Novel Metabolite

    Creator:
    Kirkemo, Lisa
    Abstract:
    In this investigation, six different endogenous thyroid hormone derivatives—T₄, T₃, TA₄, TA₃, T₁-Amine, and N-Acetylated T₁-Amine—were tested to gain insight into their permeability coefficients and efflux ratios across a monolayer of Madin-Darby Canine Kidney (MDCK II) cells. The results indicate that T₃ and T₄ were unable to traverse the membrane...
    Resource Type:
    Honors College Thesis
    Full Text:
    : ____________________________________________________ Kevin Ahern

  • Characterization of the Ovine Prolactin Promoter

    Creator:
    Tan, Taralyn
    Abstract:
    Approximately five to eight percent of domestic rams demonstrate a sexual attraction towards other rams, directing no sexual behaviors towards estrous ewes. It has been observed that these male-oriented rams (MORs) have a greater abundance of prolactin mRNA than female-oriented rams in the medial preoptic area of the anterior hypothalamus...
    Resource Type:
    Honors College Thesis
    Full Text:
    approved: ___________________________________________ Kevin Ahern Approximately five to eight

  • Assessment of academic advising models in the OSU College of Science based on student and advisor feedback

    Creator:
    Aljets, Alexandria Dukes
    Abstract:
    This study sought to explore the differences between the varied academic advising models in the College of Science at Oregon State University through the feedback of its undergraduate students and advisors. Using parallel surveys of students and their academic advisors, it found that the decentralized and centralized models each had...
    Resource Type:
    Honors College Thesis
    Full Text:
    Dr. Kevin Ahern This study sought to explore the differences between the varied academic advising

  • Purification and characterization of an alkaline phosphatase from Halobacterium salinarium

    Creator:
    McParland, Reginald Harry
    Abstract:
    The halophilic alkaline phosphatase of Halobacterium salinarium has been purified to a specific activity of 3,000-3,200 units per mg of protein. The purification scheme consisted of acetone and ammonium sulfate fractionations, and molecular sieving and adsorption chromatography on Sephadex G -50. The enzyme was stabilized during purification by the presence...
    Resource Type:
    Dissertation
    Full Text:
    : Redacted for Privacy Robert R. Becker The halophilic alkaline phosphatase of Halobacterium salinarium has

  • The purification and characterization of the fructose-1, 6-diphosphate aldolase from Bacillus stearothermophilus (NCA 2184)

    Creator:
    Quinn, Richard Paul
    Abstract:
    The thermophilic aldolase from Bacillus stearothermophilus (NCA 2184) has been purified to a specific activity of 45.5 μ-moles of fructose-1, 6-diphosphate cleaved per minute per mg of enzyme, representing a 624-fold increase over the crude extract. The preparation appeared to be homogenous by sedimentation velocity ultra-centrifugation and by a specific...
    Resource Type:
    Dissertation
    Full Text:
    STEAROTHERMOPHILUS (NCA 2184) Abstract approved: Redacted for privacy Robert R. Becker The thermophilic aldolase

  • The β-glucosidase system of the thermophilic fungus Chaetomium thermophile

    Creator:
    Lusis, Aldons Jekabs
    Abstract:
    The thermophilic fungus Chaetomium thermophile was shown to contain three major β-glucosidases, a cell-bound cellobiase, a cellbound aryl-β-glucosidase and an extracellular aryl-β-glucosidase. The enzymes were partially purified and studied with respect to thermal stability and certain kinetic parameters. Two of the β-glucosidases are fairly stable at the maximum growth temperature...
    Resource Type:
    Dissertation
    Full Text:
    Redacted for PrivacyAbstract approved: R. R. Becker The thermophilic fungus Chaetomium thermophile was

  • Hemoglobin-binding proteins in the amphibian Taricha granulosa

    Creator:
    Francis, Ralph T.
    Abstract:
    The first reported observation of hemoglobin association with a plasma protein was made by Polonovski and Jayle in 1938. Since that time, countless investigators have contributed to the characterization of the hemoglobin- binding plasma protein, haptoglobin. Haptoglobins have been found in many mammals, including humans and in various birds. However,...
    Resource Type:
    Dissertation
    Full Text:
    Taricha granulosa. Abstract approved: Redacted for Privacy Ro6irt R. Becker The first reported