Index Catalog // ScholarsArchive@OSU

Mathematically modeling transient temperature variation in a human neonate undergoing intensive blue light phototherapy for management of hyperbilirubinemia

Creator:: Gondhalekar, Vikram B.
Abstract:: Neonatal jaundice secondary to hyperbilirubinemia occurs in 60% of all term newborns and nearly all preterm newborns in the US. Severe cases of this may lead to chronic encephalopathy, neurologic deficits, and, in some cases, death. Intensive blue light phototherapy involves irradiation of a patient with high intensity light and...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Adam Higgins Neonatal jaundice secondary to hyperbilirubinemia occurs in 60% of all

Enhanced Delivery of Cryoprotectant Chemicals to Cultured Neurons

Creator:: Wilson, Jenna L.
Abstract:: Due to the many advances in the areas of biotechnology and medicine, the need for long- term storage and stabilization of biological materials is rapidly increasing. The field of biopreservation is attempting to address these issues by finding ways to maintain the integrity and functionality of proteins, cells, and organs...
Resource Type:: Honors College Thesis
Full Text:: : _________________________________________________________ Adam Higgins Due to the many advances in the areas of biotechnology and medicine

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Creator:: Laschober, Nicole B.
Abstract:: Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
Resource Type:: Honors College Thesis
Full Text:: University _____________________________________________________________________ Adam Higgins

Novel Predictive Simulation of Organ Perfusion Kinetics for Design of Cryopreservation Procedures

Creator:: Johnson, Hill S.
Abstract:: Despite the many advances in biotechnology and biomedical engineering, the need for long term organ and tissue storage remains among the unsolved problems in the field. Researchers are investigating several possible solutions to the issue that aim to maintain the function and integrity of the biological tissues during storage and...
Resource Type:: Honors College Thesis
Full Text:: : ___________________________________________________ Adam Higgins Despite the many advances in biotechnology and biomedical engineering, the

Investigating the Potential for Cryopreservation of Human Granulocytes with Concentrated Glycerol

Creator:: Moss, Alden C.
Abstract:: Granulocytes are a class of white blood cells essential to immune function. Granulocyte transfusions hold promise to treat many conditions, but the short-shelf life of granulocytes makes transfusions infeasible without a cell preservation method. The purpose of this study was to investigate the potential for cryopreservation of granulocytes using 30%...
Resource Type:: Honors College Thesis
Full Text:: :_____________________________________________________ Adam Higgins Granulocytes are a class of white blood cells essential to immune function

Investigation of the effects of cryopreservation on cellular viability and mechanical integrity of the intervertebral disc

Creator:: Forcier, Ryan J.
Abstract:: Degeneration of the intervertebral disc (IVD) is a phenomenon that has yet to be adequately addressed. Treatment options remain limited and incomplete. The ability to effectively cryopreserve IVDs would allow for better allograft transplantations and storage of samples for research purposes. This study aimed to assess how cryopreservation with different...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Higgins, Committee Member, representing Bioengineering

Bioactive and Biocompatible Coatings for Endotoxin Capture in Treatment of Sepsis

Creator:: Su, Jonathan
Abstract:: Sepsis is a blood infection caused by circulating pathogens and cell wall fragments that affects over 1 million patients per year in the United States. When bacterial cell membranes are lysed by antibiotics, cell wall fragments containing lipopolysaccharides (LPS) are released. As a result, the capture of LPS is critical...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Higgins, Committee Member, representing Chemical, Biological, and Environmental Engineering

Coaction of a Biomedical Device and Physiological Model for Thalassemia Therapy Modeling: Methods and Future Approaches

Creator:: Hull, Darke
Abstract:: The Jovanovic lab at Oregon State University (OSU) is developing iCore, a versatile blood processing platform which leverages microfluidic process intensification via increased mass transfer efficiency and decreased device footprint with the goal of creating a portable, wearable device. One application of iCore is for the treatment of hyperferremia resulting...
Resource Type:: Honors College Thesis
Full Text:: Engineering _____________________________________________________________________ Adam Lambert

Analysis and Modeling of Kinetic Parameters for Urea Hydrolysis by Bacteria for Use in Calcium Carbonate Precipitation in Aquifers

Creator:: Neighbor, Christopher J.
Abstract:: The use of ureolytic bacteria for the remediation of contaminated groundwater aquifers by inducing calcium carbonate precipitation is being studied in order to establish a better understanding of the modeling and prediction of how the bacteria will act in situ. This research has pursued the use of various ureolytic bacteria...
Resource Type:: Honors College Thesis
Full Text:: members Dr. Adam Higgins and Dr. Joe McGuire for their understanding and helpfulness. Thank you to the

Predicting Treatment Options for the Intervertebral Disc: Patient-Specific Finite Element Models

Creator:: Ahrens, Sonia R.
Abstract:: This work describes a method for incorporating patient data into a nutrient transport model of the intervertebral disc.This data was collected using MRI diffusion weighted imaging (DWI), and was converted into an apparent diffusion coefficient map (ADC map). This map was used to define the diffusion behavior of water within...
Resource Type:: Honors College Thesis
Full Text:: ___________________________________________________________________________________________________ Adam Higgins, Committee Member, representing Bioengineering

ScholarsArchive@OSU

Mathematically modeling transient temperature variation in a human neonate undergoing intensive blue light phototherapy for management of hyperbilirubinemia

Enhanced Delivery of Cryoprotectant Chemicals to Cultured Neurons

Role of P2Y₁₂ Inhibition in PAR1 Stimulated Platelet Dense Granule Release

Novel Predictive Simulation of Organ Perfusion Kinetics for Design of Cryopreservation Procedures

Investigating the Potential for Cryopreservation of Human Granulocytes with Concentrated Glycerol

Investigation of the effects of cryopreservation on cellular viability and mechanical integrity of the intervertebral disc

Bioactive and Biocompatible Coatings for Endotoxin Capture in Treatment of Sepsis

Coaction of a Biomedical Device and Physiological Model for Thalassemia Therapy Modeling: Methods and Future Approaches

Analysis and Modeling of Kinetic Parameters for Urea Hydrolysis by Bacteria for Use in Calcium Carbonate Precipitation in Aquifers

Predicting Treatment Options for the Intervertebral Disc: Patient-Specific Finite Element Models

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