Index Catalog // ScholarsArchive@OSU

The Robinson-Mannich base synthesis applied to substituted acetoacetic ester

Creator:: LaPore, Richard Francis
Resource Type:: Dissertation
Full Text:: ---HOO~--~----HOO~--~----~ ~~~~~~S4~00~--~--~~-..--.a... \)J 0 501 5 ii• i z c..... FIIUIIE

The application of salicylaldoxime to the spectrophotometric determination of iron in ores

Creator:: Durst, Dorothy Elizabeth
Resource Type:: Masters Thesis
Full Text:: DETERMINATION OF IRON IN ORES by DOROTHY ELIZABETH DURST A THESIS submitted to OREGON STATE COLLEGE

Classification of stationary phases in gas chromatography

Creator:: Chong, Elee Elizabeth
Abstract:: Ultraviolet spectroscopy and dispersive solubility parameters correlated to the ratios of retention times have proven valuable in classification of gas chromatography stationary phases by the donor-acceptor properties. Iodine was directly dissolved into stationary phases and the absorption frequency shift of complexes was correlated with the carbon tetrachloride/chloroform retention ratio on...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF ELEE ELIZABETH CHONG for the degree of Master of Science in CHEMISTRY

Fusion enhancement with neutron-rich radioactive beams

Creator:: Zyromski, Kristiana Elizabeth
Abstract:: Fusion reactions with radioactive neutron-rich projectiles have been the subject of much recent theoretical and experimental interest. Predictions of enhancement of the cross section due to the use of a neutron-rich projectile may have implications for synthesis of heavy nuclei. In this work, the fusion-fission excitation functions were measured for...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Kristiana Elizabeth

Insights into Cytostatic and Cytotoxic Properties of the Natural Product Mensacarcin

Creator:: Kaweesa, Elizabeth Namagoba
Abstract:: Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Elizabeth

Preparation and properties of crystalline potassium chloride containing trivalent cation impurities

Creator:: Hills, Marian Elizabeth
Resource Type:: Dissertation
Full Text:: CHLORIDE CONTAINING TRIVALENT CATION IMPURITIES by MARIAN ELIZABETH HILLS A THESIS submitted to

Decomposition of di-p-toluenesulfonyl-hydrazones

Creator:: Bradway, Diane Elizabeth
Abstract:: Thermal decomposition of several di-p-toluenesulfonylhydrazones was studied. It was found that the carbene decomposition of tetramethyl-1,3-cyclobutanedione, di-p-toluenesulfonylhydrazone gave two products resulting from rearrangement. One was identified as 2,5-dimethyl-1,3,4-hexatriene. A tentative structure for the second was proposed. During the course of the study, a more convenient procedure for thermal decompositions was...
Resource Type:: Masters Thesis
Full Text:: Elizabeth Bradway (Name ) Date thesis is presented (Degree ) Jsnua.rrr L5. 1965 Chemistry (Ma jor

Designing Functional Materials Based on Pyrochlore Oxides: The Role of Mixed Valence and Complex Stoichiometry

Creator:: Converse, Elizabeth Maria Sobalvarro
Abstract:: Solid state inorganic oxides play an important role in next generation electronics based on their stability, versatility, and enhanced properties over other materials. However, in order to design or tune these materials for a desired functionality it is necessary to fully understand the structure behind the properties exhibited. This dissertation...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Elizabeth Maria

The role of molecular architecture in the hydration properties of brewers’ spent grain

Creator:: Yang, Jasmin S.
Abstract:: An emerging strategy to reducing food waste is converting food processing byproducts to nutritious and inexpensive food ingredients. A relevant food processing waste stream is brewers’ spent grain (BSG), the primary byproduct of beer production. BSG is a promising candidate as a food ingredient because of its high protein and...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Elizabeth Tomasino, Committee Member, representing Department of Food Science & Technology

The rotational motion of molecules in crystalline solids

Creator:: Miller, R. E.
Abstract:: Theoretical studies and experimental results are presented for the rotational motion of molecule's in crystalline solids. The group theory is solved for molecules of any symmetry matrix isolated at a site in a crystal field of any symmetry. As the potential terrier to rotation of the molecule relative to the...
Resource Type:: Dissertation
Full Text:: Molecules in Crystalline Solids Abstract approved s Redacted for privacy Professor J. C. Decius

Molecular intensity parameters in the solid state

Creator:: Fredrickson, Larry R.
Resource Type:: Dissertation
Full Text:: . 00 ) Ti e (C4 ) = E + 0- o- J CO 2 .-co2 T3 E (00) = 1+1.1[Z B ,] o- rm-n,' mm m o-o- o- 2 am

The synthesis of trisporic acids

Creator:: Prisbylla, Michael Paul
Abstract:: A total synthesis of the fungal hormones, trisporic acids A and B, is described, starting from a -methyltetronic acid 34. A Robinson annelation of 34 with ethyl vinyl ketone affords the lactone 33. Treatment of 33 with N-bromosuccinimide gave 97, which was hydrolyzed to the lactol 103. The reaction of...
Resource Type:: Dissertation
Full Text:: from a -methyltetronic acid 34. A Robinson annelation of 34 with ethyl vinyl ketone affords the

Purification of 2,5-dihydroxyacetanilide epoxidase and mechanism of hydroquinone epoxidases

Creator:: Kirchmeier, Marc J.
Abstract:: 2,5-dihydroxyacetanilide epoxidase from Streptomyces LL-C10037 (DHAE I) catalyzes the epoxidation of hydroquinone 4, to form epoxyquinone 7. DHAE I has been purified to homogeneity, with an overall purification factor greater than 23,000. N-terminal and internal amino acid sequences have been obtained from the purified enzyme so that the epoxidase gene...
Resource Type:: Dissertation
Full Text:: News, 1995 (June 19):32-35. 5. Robinson, J. A. Enzymes of Secondary Metabolism in Microorganisms

Cold vapor atomic absorption and fluorescence analysis of mercury

Creator:: Hawley, James Edward
Abstract:: A critical study of the cold vapor atomic absorption and fluorescence instrumentation for the analysis of mercury is described. Some of the important modifications involve the reduction vessel, absorption cell, fluorescence cell, and radiation source. The new modified systems have much greater calibration sensitivities and lower detection limits than those...
Resource Type:: Masters Thesis
Full Text:: for privacy J. D. '7Ing161 A critical study of the cold vapor atomic absorption and fluores- cence

Spectroscopic studies of molecular dynamics and structure at low temperature : I. Torsional barriers for multitop molecules. II. Vibrational energy transfer. III. Carbon trihalide free radicals

Creator:: Rojhantalab, Hossein Mohammad
Resource Type:: Dissertation
Full Text:: privacy Dr. J. W. Nibler'' Abstract approved: Molecular dynamics and structures of solids and matrix

Secondary metabolism in Streptomyces murayamaensis

Creator:: Melville, Chris R.
Resource Type:: Dissertation
Full Text:: : Professor Stein J. Gould A multidisciplinary approach to unraveling the biosyntheses of secondary

Structural and preliminary biosynthetic studies on new metabolities produced by Streptomyces murayamaensis mutant MC2

Creator:: Hassan, Awatef Mahdi
Resource Type:: Masters Thesis
Full Text:: MC2. Abstract approved: Steven J. ould C H3 A procedure for efficient and reproducible isolation

A study of simultaneous diffusion of Ca²⁺ and Sr²⁺ in alkali chlorides

Creator:: Machida, Hisashi
Abstract:: The simultaneous diffusion of Ca 2+ and Sr 2+ ions in purified single crystals of KC1 and NaC1 was studied over the temperature ranges from 451°C to 669°C in KC1 and from 448°C to 683°C in NaCl. A radioactive tracer technique was used in two types of measurements: diffusion from...
Resource Type:: Dissertation
Full Text:: DIFFUSION OF Ca 2+ AND Sr 2+ IN ALKALI CHLORIDES Abstract approved: Redacted for privacy fillfiam J

The infrared spectrum of cyanate ion in different environments

Creator:: Maki, Arthur G.
Resource Type:: Dissertation
Full Text:: cubic and higher terms are neglected 3t( z v - L_ ~J ~~· r.i <~j= I where f .. (J 12 If

Natural and semi-synthetic compounds with biocidal activity against arthropods of public health importance

Creator:: Khasawneh, Mohammad A.
Abstract:: This study identified new compounds with pest control activities. The two sources of candidates that were followed here were the main heartwood extract of Alaska Yellow Cedar (AYC) constituents and several semi-synthetic counterparts. Five compounds were isolated and identified for the first time in AYC heartwood in this research: two...
Resource Type:: Dissertation
Full Text:: The author would like to express sincere appreciation to Prof. Joe J. Karchesy for his help, guidance

LL-C10037α and MM 14201 : structure, biosynthesis and enzymology of two epoxysemiquinone antibiotics

Creator:: Shen, Ben
Resource Type:: Dissertation
Full Text:: approved: Ur. Steven J. Gould Antibiotic LL-C10037a, has now been shown to have the epoxysemiquinone

Scanning tunneling microscopy of organic monolayers at the fluid- solid interface

Creator:: Marty, Valerie J.
Abstract:: More that just magnificent views of atoms and molecules, Scanning Tunneling Microscopy, STM, images have the potential to answer some fundamental questions relating to surface molecular dynamics and bonding characteristics of localized species versus more common analytical tools that provide average of bulk sample information. A special feature of the...
Resource Type:: Masters Thesis
Full Text:: fluid- solid interface AN ABSTRACT OF THE THESIS OF Valerie J. Marty for the degree of Master of

Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

Creator:: Brumsted, Corey J.
Abstract:: Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
Resource Type:: Dissertation
Full Text:: ) spectrum of Z-19….………………………………..………288 Appendix Figure 6.92: 13C NMR (CDCl3) spectrum of Z-19

Photoresist and ion-exchange chemistry of HafSOx

Creator:: Telecky, Alan J.
Abstract:: The chemistry of hafnium oxide based and materials are described in the context of ion exchange and lithography. HafSOx, represented by the composition HfO₂₋[subscript x](SO₄)x, is described to possess a significant capacity towards ion exchange in acidic and basic solutions, enabling films of HafSOx to be cleanly and readily be...
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE DISSERTATION OF Alan J. Telecky for the degree of Doctor of Philosophy in Chemistry

Time-of-flight scattering and recoil spectrometry (TOF-SARS) applied to molecular liquid surfaces : a new approach to surface composition and orientation

Creator:: Gannon, Thomas J.
Abstract:: In spite of their importance in many systems, liquid surfaces have been explored at the microscopic level to a much lesser extent than solids. Most surface analysis must take place in vacuum, a major drawback for liquids. The technique of time-of-flight scattering and recoil spectrometry (TOF-SARS) has been applied to...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF Thomas J. Gannon for the degree

Laser excited fluorescence and vibrational relaxation of matrix isolated metal oxides

Creator:: Bares, Steven J.
Abstract:: The work presented in this thesis deals with the mechanisms by which a vibrationally excited diatomic molecule gives up its energy to a host monatomic lattice at low temperature. The vibrational lifetimes (v"=1) of the metal oxides Ba0 and A10 in their ground electronic states are studied using pulsed dual...
Resource Type:: Dissertation
Full Text:: . Laser Excited Fluorescence and Vibrational Relaxation of Matrix Isolated Metal Oxides by Steven J

Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Creator:: Tonsiengsom, Sorasaree
Abstract:: Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
Resource Type:: Dissertation
Full Text:: , 104, 1776-1777. 4. a) Xu, Y. –z.; Yakushijin, K.; Horne, D. A. J. Org. Chem. 1996, 61, 9569- 9571

Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

Creator:: Adpressa, Donovon A.
Abstract:: Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
Resource Type:: Dissertation
Full Text:: , Z.; Capon, R.; Bills, G.; Kerr, R. Mar. Drugs 2017, 15, 254. 41. Lösgen, S.; Magull, J.; Schulz, B

Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

Creator:: Melbardis, John
Abstract:: In previous work (Blakemore et al. Org. Lett. 2005, 7, 4721; Heterocycles 2006, 70, 609), successful elaborations of the lupine alkaloids (±)-α-isosparteine (dl-2) and (±)-β-isosparteine (dl-3) were realized from a common tetraoxobispidine precursor, 3,7-diallyl -2,4,6,8-tetraoxo-3,7-diazabicyclo[3.3.1]nonane (93). Herein, the tetraoxobispidine approach to lupine alkaloids was extended to a total synthesis of...
Resource Type:: Masters Thesis
Full Text:: ” approaches to sparteine. The biosynthesis of “sparteine” suggested by Robinson was based on an incorrect

Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

Creator:: Ferreira, Andrew
Abstract:: The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE DISSERTATION OF Andrew J. Ferreira for the degree of Doctor of Philosophy in Chemistry

Fluorescence studies on the bases of the nucleic acids in solution at room temperature

Creator:: Hauswirth, William Walter
Abstract:: Fluorescence of adenine, guanine, thymine, cytosine, and uracil has been detected at room temperature in neutral aqueous solution using a digital signal accumulation technique and right angle fluorescence detection from solutions with absorbances between 0. 4 and 0. 7. The quantum yields are respectively 2.6 x 10⁻⁴, 3.0 x 10⁻⁴,...
Resource Type:: Dissertation
Full Text:: electrons j in the molecule, er.J . J A more explicit view of electronic states in organic molecules

Drug Discovery from Diverse Bacteria – Bioactivity-guided Isolation of Known and New Metabolites

Creator:: Zhu, Chenxi
Abstract:: Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
Resource Type:: Dissertation
Full Text:: configuration was determined by Mosher ester analysis, J-based coupling analysis, and DFT modeling

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:: Yang, Liping
Abstract:: The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....
Resource Type:: Dissertation
Full Text:: affinity agonist of FXR; and Z-guggulsterone (GG), an in vitro antagonist of the steroid chemotype

An investigation of the nucleophilic substitution of the chlorosubstituted pyrimidines

Creator:: Nazeeri, Makeen Ahsan
Resource Type:: Masters Thesis
Full Text:: NUCLEOPHILIC SUBSTITU- TION Or. THE CHLOROSUBSTITUTED PYRIMIDINES for the M.S. in (Dd;j Abstrac t approved

Synthetic studies on alkaloids : part I, an approach toward the synthesis of (̳+)-koumine : part II, an approach toward the synthesis of (̳+)-morphine

Creator:: Stappenbeck, Frank
Resource Type:: Dissertation

A Diels-Alder approach to biaryl synthesis

Creator:: Ashburn, Bradley O.
Abstract:: An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...
Resource Type:: Dissertation
Full Text:: . Weinreb, S. M.; Basha, F. Z.; Hibino, S.; Khatri, N. A.; Kim, D. Pye, W. E.; Wu, T.-T. J. Am. Chem

Part I: Synthetic Studies Towards Viridin, Halenaquinone, and Obtusanal. Part II: Analysis, Synthesis, and Characterization of Coronene Derivatives.

Creator:: Waldenmaier, Pieter K.
Abstract:: This thesis is separated into three distinct projects. First, synthetic studies towards the furanosteroid viridin shown in part I. Second, synthetic studies towards the diperene obtusanal shown in part II. Third, the analysis, characterization, and synthesis of coronene derivatives towards their application in organic batteries shown in part III. Significant...
Resource Type:: Dissertation
Full Text:: would also like to thank my parents Shelley A. Szajner, and Pieter J. Waldenmaier, and my family. They

Applicability of the Diels-Alder reactions of o-quinones towards the synthesis of quassinoids and preparation of oxygenated benzeneacetic acids

Creator:: Stirchak, Eugene P.
Resource Type:: Dissertation
Full Text:: stereochemistry via equilibration. The Robinson annulation, widely employed in natural products synthesis, has

The Role of Materials Chemistry in Designing Advanced Color Inorganic Pigments

Creator:: Medina, Elena A.
Abstract:: The results of the research presented in this work are related to synthesis and investigations of novel color inorganic pigments having various structures and shades. Inorganic pigments play a major role in contemporary life. They are used in paints, rubber, plastic, cosmetics etc. Searching for new, stable, environmentally benign and...
Resource Type:: Dissertation
Full Text:: Giampaoli, Joseph Tang, Max Wallace, Brett Duell, Paradron Lektrakoontara (Junior) and Elizabeth

Synthetic studies on alkaloids : part I; asymmetric synthesis of (±) codeine. Formal synthesis of (±) morphine : part II; a unified asymetric approach toward synthesis of polyhydroxylated pyrrolizidine alkaloids, australine and alexine

Creator:: Hrnciar, Peter
Resource Type:: Dissertation
Full Text:: resultant carboxylic acid 73 of (S) configuration was converted to tetralone 90. Robinson annulation of

A microdetermination of hydroxyl and acetate contents of sugars and glycosides

Creator:: Clarke, Ray Allen
Resource Type:: Masters Thesis
Full Text:: ., 1043 (1O4). 2. Bailey, A. J., and. Robinson, R. J., Liikrochemie, 2:.' :33 (1934). 3. Beiiibry, T

Part I : synthesis of azetidin-2-ones from pyrazolidin-3-ones ; Part II : synthesis of a subunit of the immunosuppressant FK-506

Creator:: Toske, Steven Gerald
Resource Type:: Dissertation
Full Text:: penicillin was studied intensively after 1943. This led to the extraordinary suggestion by Robinson that

A spectrophotometric study of niobium (V) in hydrochloric acid solution

Creator:: Kanzelmeyer, James Herbert
Resource Type:: Dissertation
Full Text:: ~----------------------------------------------------------------~ FIGURE 3 HYDROLYSIS OF Ne- ZR SOLUTIONS Ztt INa RATIO • 0 L&J 0 z <1: m a:: 0 CJ) mo.1 <1

Centrifugal Partition Chromatography, Microfabrication, and a Smartphone-based Detection Platform : Analytical Chemistry from Preparative-scale Separation to Micro-scale Analysis

Creator:: Boonloed, Anukul
Abstract:: Analytical chemistry is an area of chemistry primarily focused on the study and use of instruments for separation, identification, and quantification of an analyte of interest. Specifically, separation science within analytical chemistry often refers to the process of dividing mixtures into their small component parts based on differences in their...
Resource Type:: Dissertation
Full Text:: Robinson and her group for the introduction to Chlorociboria and the assistance with the fungal culture

Studies toward the total synthesis of phorboxazole A

Creator:: Kuntiyong, Punlop
Abstract:: Studies toward the total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, were conducted and resulted in a route to an advanced intermediate, C4-C32, for this purpose. A key feature of our approach is the stereoselective synthesis of two cis-2,6-disubstituted tetrahydropyrans present in the macrolide portion of...
Resource Type:: Dissertation
Full Text:: . A.; Tackett, L. P. J. Org. Chem. 1993, 58, 2538. 2 (a) Pettit, G. R; Cichacz, Z. A.; Herald, C. L

Applications of the Mannich reaction

Creator:: Bush, David Clair
Resource Type:: Dissertation
Full Text:: americen chamical society 70:669-670. 1948. 3. Alexander, 111±ot R. and Elizabeth J. TJnderhill. Studies

Studies toward the synthesis of halichlorine and pinnaic acid

Creator:: Korf, Eric A.
Abstract:: Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered...
Resource Type:: Dissertation
Full Text:: ) chloride, gave the Z vinyl chloride 78 (Scheme 17). Global silylation with subsequent release of the

Synthesis of two subunits of avermectin B1a

Creator:: Dantanarayana, Anura Pathmasiri
Abstract:: Avermectins are a group of potent anthelmintic agents produced by Streptomyces avermitilis. They are active at extremely low dosages and are now in commercial use. In this study, the synthesis of two segments of avermectin B[subscript 1a] are described. The synthesis of the hexahydrobenzofuran subunit (segment A) began with the...
Resource Type:: Dissertation
Full Text:: , Kozikowski 38 reported a model study based on the intramolecular CH = CHNO2 McO-J 0 BzO 31 MeO 33

Studies toward the total synthesis of (+)-providencin

Creator:: Jana, Somnath
Abstract:: Studies toward the total synthesis of (+)-providencin (1), a highly oxygenated cembranoid dipterpene with a unique bicyclo[12.2.0]hexadecane skeleton and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 320 and 332 which contain all of the carbon atoms of 1. In a first generation approach...
Resource Type:: Dissertation
Full Text:: ) Marshall, J. A.; Robinson, E. D. J. Org. Chem. 1990, 55, 3450. 22 13. Marshall, J. A.; Sehon, C. A

The nuclear reduction of certain pyrimidines with palladized charcoal

Creator:: Aft, Harvey
Resource Type:: Dissertation
Full Text:: conveniently into two classes: 1. the reaction of i, 3-diamines (Z, 7, 8, 14, 24, 25, 28, 29, 32, 41, 52

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