Index Catalog // ScholarsArchive@OSU

Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Creator:: Tonsiengsom, Sorasaree
Abstract:: Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
Resource Type:: Dissertation
Full Text:: and Gabriel-Robinson oxazole synthesis with chiral, nonracemic keto amides. An integral aspect of

Laser patterned porous-media microfluidic analytical devices : fabrication methods and applications in bioassays

Creator:: Sumantakul, Saichon
Abstract:: The concept of reducing laboratory operations into microfluidic devices has been an attractive area of research for several decades. Due to several advantages of porous-media microfluidic devices including low mass, portability, power-free fluid transport, and the ability to store dried reagents in the porous structures, these devices show great promise...
Resource Type:: Dissertation

Stereospecific Synthesis of Stereotriad Motifs and Alkenes Using Enantioenriched sp³-Hybridized Carbenoids

Creator:: Xun, Sun
Abstract:: Enantioenriched sp³-hybridized carbenoid reagents CR1R2MX (X = nucleofuge, M = electrofuge) of different types were investigated for the synthesis of polysubstituted alkyl chains by iterative stereospecific reagent-controlled homologation (StReCH) and for the stereospecific connective synthesis of alkenes by eliminative cross-coupling. In the first part, putative enantioenriched α-chloroalkyllithiums (CHRLiCl) were employed...
Resource Type:: Dissertation

Functionalization of carbon nanotubes for effective biosensing and potential biomedical applications

Creator:: Adenuga, Adeniyi A.
Abstract:: Since their discovery in the 1990s, the great potential of carbon nanotubes (CNTs) has made them a focus of many research endeavors, including their application as components of biosensors. The inherent chemical "inertness" of CNTs makes their application to biosensing a challenge. It is necessary to "decorate" their surfaces to...
Resource Type:: Dissertation

Formation of hybrid supramolecular assemblies using biological molecules and transition metals

Creator:: Smith, Rachelle M. S.
Abstract:: Naturally occurring assemblies, such as DNA and proteins, utilize intermolecular forces (i.e H-bonding and van der Waals) to assemble. Utilizing these electrostatic interactions has only just started in the past five decades to be a tool used in synthetic chemistry in what is known as supramolecular chemistry. Supramolecular chemistry has...
Resource Type:: Dissertation

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Creator:: Overacker, Ross D.
Abstract:: Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Resource Type:: Dissertation

Synthesis and Characterization of Novel Metal-Oxo Clusters as the Building Blocks in Nature and Synthesis

Creator:: Amiri, Mehran
Abstract:: Metal-oxo clusters can be described as soluble pieces of metal-oxide frameworks. Metal-oxo clusters are also the building blocks for the Metal-Organic Frameworks (MOFs) and coordination polymers. A better knowledge of metal-oxo clusters helps fundamentally understand geosciences, molecular engineering, catalysis, single-molecule magnetism, and MOFs for synthesis, design, and modification of these...
Resource Type:: Dissertation

Venturing Beyond Crystallinity and Into Amorphous Space : A Na-ion Battery Perspective

Creator:: Bommier, Clement
Abstract:: As scientists, we have an affinity for order: repeating crystal structures, Euclidean space, continuous functions… Even concepts such as defects are discussed in the context of distracting from order. Things are most logical and best described in straightforward, taxonomical fashion. But what happens when the very application desired is dependent...
Resource Type:: Dissertation
Full Text:: working with including, Caleb Mickey, Adrian Hinkle, Gabriel Nowak, Will Schreiber, David Wen, and David

Design, construction and application of an instrument for simultaneous measurement of molecular fluorescence, absorbance and chemiluminescence

Creator:: Yappert, Marta Cecilia
Abstract:: An instrument was constructed to measure molecular fluorescence (FL) or chemiluminescence (CL) and absorbance (ABS) simultaneously. The lower, middle, and upper portions of the test solution are probed to obtain ABS, FL, and CL data. Optical fibers are used extensively. The ABS and FL or CL spectra are acquired in...
Resource Type:: Dissertation

Computational Investigation and Prediction of Mechanisms and Stereocontrol in Complex Organic Reactions

Creator:: Pattawong, Ommidala
Abstract:: Complex organic transformations, such as the addition of pyrrole to ketene using planar chiral organocatalyst (*PPY), the four-component anhydride- Manniach reactions, and the site-selective desymmetrization of meso-1,2-diol, are remarkable synthetic reactions that provide high yield and high selectivity. However, the exact mechanism and origins of stereocontrol for theses synthetic organic...
Resource Type:: Dissertation

ScholarsArchive@OSU

Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Laser patterned porous-media microfluidic analytical devices : fabrication methods and applications in bioassays

Stereospecific Synthesis of Stereotriad Motifs and Alkenes Using Enantioenriched sp³-Hybridized Carbenoids

Functionalization of carbon nanotubes for effective biosensing and potential biomedical applications

Formation of hybrid supramolecular assemblies using biological molecules and transition metals

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Synthesis and Characterization of Novel Metal-Oxo Clusters as the Building Blocks in Nature and Synthesis

Venturing Beyond Crystallinity and Into Amorphous Space : A Na-ion Battery Perspective

Design, construction and application of an instrument for simultaneous measurement of molecular fluorescence, absorbance and chemiluminescence

Computational Investigation and Prediction of Mechanisms and Stereocontrol in Complex Organic Reactions

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