Graduate Thesis Or Dissertation
 

Formation of hybrid supramolecular assemblies using biological molecules and transition metals

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/bg257n86x

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  • Naturally occurring assemblies, such as DNA and proteins, utilize intermolecular forces (i.e H-bonding and van der Waals) to assemble. Utilizing these electrostatic interactions has only just started in the past five decades to be a tool used in synthetic chemistry in what is known as supramolecular chemistry. Supramolecular chemistry has led to two Nobel prize for its contribution to chemistry and can be utilized to build up larger novel complexes and assemblies that hold hope for the advancement of much needed applications. The work presented will utilize supramolecular chemistry and electrostatic interactions to form new assemblies by utilizing two biologically relevant molecules: deoxycholic acid and cytosine. The first study looked at making new assemblies from deoxycholic acid, a natural steroidal bile acid found in the body. Bile acids have interesting properties as facile amphiphiles that act as detergents, not through a head and tail but through the hydrophobic and hydrophilic faces on the steroidal backbone. By combining deoxycholic acid with Zn2+, two new compounds were formed: a polymeric compound and a Zn tetramer. The formation of these compounds relied on the solvent type present (i.e organic or aqueous) in the reaction solution. The compounds were even found to be conducive to solid state transformations where exposure of solid state crystals to different solvent types led to a reversable reaction between phases. Then these compounds were found to have dye absorption and dye degradation properties in the polymer form. Lastly, a third compound was formed with Cd2+. This structure was determined to have the same general assembly as that of the polymeric Zn complex. The second study evaluated the interaction of polyoxometalates (POMs) with cytosine silver base pair complexes. Four different structures were formed showing how the POM and the cytosine silver base pair complex can influence each other and how they form into a complex. Multiple intermolecular forces hold these structures together. This study provides an introduction to the promising potential for polyoxometalates to bond with metallo-DNA systems to form complex structures.
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  • Pending Publication
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  • 2021-08-17 to 2023-09-18

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