Purpose: To compare target dose conformality and OAR sparing afforded by VMAT and HT for pancreatic cancer.
Materials and Methods: A retrospective planning study was performed in 18 patients. Total treatment dose was 59.4Gy. OAR and PTV mean doses, conformity indices, isodose volumes, and integral doses were compared. The relationship...
An interactive map of important watersheds in the United States was created for use as a teaching tool in an estuarine ecology class. Figures and explanations of important factors influencing river ecology were created using data downloaded from the U.S. Geologic Survey. This interface serves as a visualization of biological,...
Coral reefs are diverse ecosystems and serve many purposes including preventing erosion on coastlines and acting as a source of food, income, and culture. Acropora cervicornis, a staghorn coral, has faced a significant 80-89% decline in the Caribbean, attributed to a poorly-characterized epizootic, White Band Disease (WBD). Previous studies showed...
Seed germination is strictly defined as the physiological events before radicle
protrusion through the endosperm cap, the endosperm region adjacent to the radicle tip.
There are two opposing forces governing seed germination: the growth potential of the
embryo and the mechanical resistance of the endosperm cap. The endosperm cap cell...
From the formation of reservations, Native Americans have faced many
difficulties and continue to deal with cultural barriers today. Particularly within a medical
setting, there is a worldview disconnect between western medicine and traditional Native
healing. It would be useful to interview Native pupils to learn about their uses of...
The Hawai’i County Band is based in Hilo, Hawai’i and was founded in 1883 by brothers Joaquin and Jules Carvalho. After the Kingdom of Hawai’i was overthrown in 1893, the band became known as the Hilo Portuguese Band and after the United States made Hawai’i a territory, the band became...
RNA silencing plays a critical role in plant defense against viral infection. Plants use virusderived
small interfering RNA to target and silence invading viruses. The antiviral silencing
pathway can be broken down into three conceptual stages: initiation, amplification, and systemic
movement. The molecular mechanisms of silencing initiation are not well...
Salmonella is a bacterium responsible for several illnesses, including typhoid fever,
paratyphoid fever, and salmonellosis. It is commonly found in animal products, including
poultry. Determination of potential reservoirs of Salmonella contamination is important
to mitigate the risk of transmission and possible outbreaks. Outbreaks can negatively
impact the livelihood of local...
Science is difficult for even its researchers to understand. Science journalists must understand scientific discoveries well enough to write clear, accurate explanations of scientific discoveries for laypeople. A sense of ethical judgment will help journalists ensure that their accounts are reliable and appropriate. Responsible science journalists will maintain a working...
Myxozoa have been found worldwide; these parasites infect a wide variety of hosts, but have been found most often in fish. Carassius auratus (goldfish), a popular aquarium fish and a widespread invasive species, have been identified as an intermediate host for several myxozoan species. Some myxozoan parasites are pathogenic and...
Ceratonova shasta is a myxozoan parasite that affects populations of salmonid species in the Pacific Northwest and is the cause of enteronecrosis. It has a complex life cycle involving two hosts; a definitive annelid host, Manayunkia speciosa (polychaete), and an intermediate salmonid host. Klamath River M. speciosa are genetically variable...
Using X-ray computed tomography (CT) scanning to characterize the physical characteristics of soil and sediment cores allows scientists to observe and analyze stratigraphy without destroying the integrity of different layers. Microbiologists often work with geologists to characterize the microbial communities in such cores; however, X-rays are known to be destructive...
Aging is a complex biological phenomenon that alters many different physiological processes. Although many age-related phenotypes, such as neurodegeneration, weakening circadian rhythms, and inflammaging, are well-studied, the links between them are not. To elucidate these links we created an inflammation-like state in Drosophila melanogaster by overexpressing Relish (Rel), an NFκB...
Neurofibromatosis type 2 (NF2) is a genetic disorder caused by the inactivation of the
merlin tumor suppressor gene. NF2 patients develop bilateral vestibular schwannomas
(VS) and other nervous system tumors with no effective drug treatment option. In
pathological conditions, including NF2, production of the oxidant peroxynitrite leads to
protein tyrosine...
Canine transitional cell carcinoma (TCC) has been shown to have a substantial inflammatory component. It exhibits genotypic and morphologic elements that resemble its human counterpart. Cyclooxygenases (COX) are key enzymes in the synthesis of proinflammatory molecules, such as prostaglandins. Excess prostaglandin production through cyclooxygenases may promote oncogenesis and progression of...
Koi herpesvirus (KHV) is a new emerging viral pathogen of koi and common carps. It has been demonstrated that KHV becomes latent in the white blood cells in the recovered koi. The latent KHV can be reactivated under stressful conditions, such as heat and injury, and the reactivated viruses can...
Our laboratory is exploring the mechanism of action of a novel broad spectrum antiviral, ST-669. This compound has activity against a variety of different viruses and the obligate intracellular bacterium, Chlamydia. In this study, we explored the effects of ST-669 when the cell cycle of the host cells was altered....
Cyanobacterial blooms are a growing concern in the Pacific Northwest because of their
threat to watershed health and drinking water supplies. Bacteriophages are pathogens of
bacteria and may contribute to the growth and decline of seasonal blooms. Bacteriophage
S-CRM01, a lytic T4-type myophage, has been isolated from a freshwater strain...
Cyanobacterial blooms are a growing concern in the Pacific Northwest because of their
threat to watershed health and drinking water supplies. Bacteriophages are pathogens of
bacteria and may contribute to the growth and decline of seasonal blooms. Bacteriophage
S-CRM01, a lytic T4-type myophage, has been isolated from a freshwater strain...
Myxobolus squamalis is a Myxozoan parasite of salmonids, which contributes to lowered fitness of hatchery and wild fish in the Pacific Northwest of North America. The only GenBank DNA sequence of M. squamalis is from Oncorhynchus tschawytscha (Chinook), but is not linked to a published morphological description. There is a...