Index Catalog // ScholarsArchive@OSU

Understanding chlamydial biology through genome sequencing and comparative genomics

Creator:: Jeffrey, Brendan
Abstract:: The human pathogen Chlamydia trachomatis displays different phenotypes between serovars both in vivo and in vitro. The study of chlamydial biology has been hampered by the lack of a tractable genetic system. Here, chlamydial isolates with known phenotypes as well as strains generated though recombination were fully sequenced to address...
Resource Type:: Dissertation
Full Text:: that lead to difference in growth rate and infectivity. Serovar G is proportionally more common in

Molecular mechanisms of peroxisome proliferator-activated receptor signaling

Creator:: Dowell, Paul T.
Abstract:: Peroxisome proliferator-activated receptors (PPARs) are members of a large group of ligand-regulated transcription factors that includes nuclear receptors for steroid and thyroid hormones, retinoids and vitamin D₃. Synthetic fibrates and thiazolidinediones that bind to and activate PPARs are used efficaciously in humans to remedy hypertriglyceridemia and non-insulin dependent diabetes mellitus,...
Resource Type:: Dissertation
Full Text:: the conversion of macrophages into artherosclerotic lesion-forming foam cells (Nagy, et al., 1998

Transcriptional repression mediated by a novel family of C₂H₂ zinc finger proteins

Creator:: Senawong, Thanaset
Abstract:: Two novel and highly related C₂H₂ zinc finger proteins (CTIP1/BCL11A/EVI9 and CTIP2/BCL11B/Rit1) have been implicated in COUP-TF signaling, etiology of myeloid and lymphoid malignancies, and hematopoietic cell development. However, the precise cellular function(s) and the contribution of these proteins to neoplastic processes and hematopoietic cell development remain unknown. The goal...
Resource Type:: Dissertation
Full Text:: ; Heinzel et al., 1997; Nagy et al., 1997), and Sin3A (Huang et al., 2000). A third class of HDACs

Computational Approaches for Understanding Combinatorial Gene Regulation

Creator:: Ansariola, Mitra
Abstract:: Gene regulation is a complex mechanism that controls the spatial and temporal expression of genes in a living cell. My dissertation studies focus on two problems. First, tissue-specific gene expression prediction from DNA sequence and chromatin state, and second, the accurate discovery of small over-represented regulatory circuits in gene regulatory...
Resource Type:: Dissertation

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Creator:: Garcia, Gloria R.
Abstract:: The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Resource Type:: Dissertation

Characterization of the response mediated by the plant disease susceptibility gene LOV1

Creator:: Gilbert, Brian M.
Abstract:: Victoria blight, caused by fungus Cochliobolus victoriae, is a disease originally described on oats and recapitulated on Arabidopsis. Victoria blight is used as a model plant disease that conforms to an inverse gene-for-gene interaction. C. victoriae virulence is dependent upon its production of victorin, a host-specific toxin that induces programmed...
Resource Type:: Dissertation
Full Text:: , susceptibility to Periconia circinata producing the host-selective, PC-toxin is dependent on a NB-LRR (Nagy and

Interactions of auxin with ethylene and gravity in regulating growth and development in tomato (Lycopersicon esculentum, Mill.)

Creator:: Madlung, Andreas
Abstract:: Plant growth, development, and environmental responsiveness are dependent on hormone-induced gene expression. This dissertation reports multiple interactions between the plant hormones auxin and ethylene and investigates their contribution to the gravitropic response, elongation growth, adventitious root formation, callus and tracheary element initiation and growth, and flower development. Four mutants of...
Resource Type:: Dissertation
Full Text:: -resistance leads to increase in pigment production 133 4.5.3. Ethylene-auxin ratios may determine g ravicu

An emerging role for the exocyst : plant morphogenesis

Creator:: Cole, Rex A.
Abstract:: Plants develop a vast array of cell shapes and sizes by selectively modifying their surrounding cell walls to expand in some regions and not in others. This process of morphogenesis requires the delivery of secretory vesicles to specific locations at the cell periphery, where exocytosis adds new membrane and proteins...
Resource Type:: Dissertation
Full Text:: , light blue pollen grain, or a purple pollen tube growing out of the grain (Figure 2.4A-G). Stigmas

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:: Myzak, Melinda C.
Abstract:: Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Resource Type:: Dissertation

Alternative splicing in the obligate biotrophic oomycete pathogen, Pseudoperonospora cubensis

Creator:: Cumbie, Jason S.
Abstract:: Oomycetes are some of the most devastating pathogens, causing upwards of billions of dollars of damage each year to plants. They also diminish ecological diversity and health through the destruction of trees and shrubs. The genome sequence of Pseudoperonospora cubensis, an obligate plant pathogen and causative agent of downy mildew...
Resource Type:: Dissertation
Full Text:: dpi (G) haustoria (labeled with “h”) have formed. Colonization of the mesophyll continues through 8

ScholarsArchive@OSU

Understanding chlamydial biology through genome sequencing and comparative genomics

Molecular mechanisms of peroxisome proliferator-activated receptor signaling

Transcriptional repression mediated by a novel family of C₂H₂ zinc finger proteins

Computational Approaches for Understanding Combinatorial Gene Regulation

Unraveling the endogenous functions of the aryl hydrocarbon receptor (AHR) and characterizing a novel long non-coding RNA (slincR) that contributes to AHR-mediated toxic responses in zebrafish

Characterization of the response mediated by the plant disease susceptibility gene LOV1

Interactions of auxin with ethylene and gravity in regulating growth and development in tomato (Lycopersicon esculentum, Mill.)

An emerging role for the exocyst : plant morphogenesis

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Alternative splicing in the obligate biotrophic oomycete pathogen, Pseudoperonospora cubensis

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