Search Constraints

Start Over
Filtering by: Subject Enzymes -- Mechanism of action Remove constraint Subject: Enzymes -- Mechanism of action Degree Field Molecular and Cellular Biology Remove constraint Degree Field: Molecular and Cellular Biology

Search Results

  • In vitro and in vivo approaches for the functional characterization of the scaffold protein, GRASP

    Creator:
    Venkataraman, Anand
    Abstract:
    Studies using the pluripotent embryonic carcinoma cell line, P19, as a retinoic acid (RA)-responsive model system have been instrumental towards our understanding of the RA-dependent signaling pathways in development and homeostasis. Grp1-associated scaffold protein (GRASP; also known as Tamalin) was first identified by our group, as a gene robustly induced...
    Resource Type:
    Dissertation
    Full Text:
    in vitro albeit by an unknown mechanism. Furthermore, the in vivo role of GRASP is poorly

  • Transcriptional repression mediated by a novel family of C₂H₂ zinc finger proteins

    Creator:
    Senawong, Thanaset
    Abstract:
    Two novel and highly related C₂H₂ zinc finger proteins (CTIP1/BCL11A/EVI9 and CTIP2/BCL11B/Rit1) have been implicated in COUP-TF signaling, etiology of myeloid and lymphoid malignancies, and hematopoietic cell development. However, the precise cellular function(s) and the contribution of these proteins to neoplastic processes and hematopoietic cell development remain unknown. The goal...
    Resource Type:
    Dissertation
    Full Text:
    catalyzed by member(s) of class I and II HDACs. One possible mechanism is that CTIP proteins may exert ISA