Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
The efficiency of powdered corncob as a tablet disintegrating
agent was compared to that of a number of wood products and to
starch, the most popular agent used today. Corncob appeared to
be superior in its disintegrating effectiveness.
The optimum particle size, at which powdered corncob produced
its best disintegrating...
A study has been made of ointment bases prepared from
mineral oil thickened with Bentone 38 gellant.
The experimental work was divided into two distinct
parts: (1) the development of ointment bases using the Bentone
gellants, and (2) subsequent comparison of these bases
with White Petrolatum, Plastibase Hydrophilic, and other...
The development and evaluation of a system for the handling, maintenance
and transcription of nursing home patient care orders are
described.
Before implementation of this documentation system, the study
nursing home was found to be out of compliance with various state,
federal and professional practice standards related to patient care...
Dyphylline is an analog of theophylline and the latter
is the most popular member of the methylxanthine family in
use for the treatment of asthma. Although dyphylline is
devoid of some problems associated with theophylline, a
reported short half-life has made it's clinical usefulness
limited. To avoid this problem a...
The role of iron in the body is well known for it is a component of hemoglobin, myoglobin, cytochrome, enzyme catalase and peroxidase. Iron deficiency anemia is widespread among vulnerable groups in industrialized societies and in the general population of tropical developing areas. In the United States there are ten...
The relative bioavailability and pharmacodynamics
of tolbutamide from two different commercially available
tablet products has been evaluated in healthy subjects
in a single dose cross over study. Products were aged
by exposing tablets to 98% relative humidity for 3 days
at ambient temperature which was found to differentially
affect both...