Graduate Thesis Or Dissertation
 

A study of powdered corncob as a disintegrating agent in compressed tablets

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  • The efficiency of powdered corncob as a tablet disintegrating agent was compared to that of a number of wood products and to starch, the most popular agent used today. Corncob appeared to be superior in its disintegrating effectiveness. The optimum particle size, at which powdered corncob produced its best disintegrating activity, was found to be about No. 40 mesh size U.S.P. The tablet disintegrating action of corn- cob and starch in tablets containing some partially or fully insoluble materials such as acetysalicylic acid, calcium carbonate, and sulfadiazine was tested. Corncob proved to be superior to starch in all these tests. The three layers of corncob were separated and tested individually for their tablet disintegrating action. The pith portion showed superior results over the other two layers. The possible role of starch and/or cellulose in the tablet disintegrating activity of corncob was examined. Cellulose and starch appeared to potentiate the disintegrating effectiveness of one another. The mechanism through which corncob is thought to produce its disintegration action was studied. It was concluded that corncob produced its effect through an "absorb moisture and swell" type of action.
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