Index Catalog // ScholarsArchive@OSU

Preformulation studies for oral dosage forms of lactobacilli

Creator:: Liou, Grace Yow-Hwa
Abstract:: Lactobacilli have been used in the dairy and pharmaceutical industries because of their nutritious and/or therapeutic effects. Lactobacillus acidophilus and Lactobacillus bulqaricus were isolated from a commercially available product and studied for their growth and colony characteristics as described in Chapter I and Chapter II. Survival of these lactobacilli in...
Resource Type:: Masters Thesis
Full Text:: dairy and phar- maceutical industries because of their nutritious and/or therapeutic effects

1) Improving the Uptake and Retention of Gadolinium in Tumors for Potential Gadolinium-Neutron Capture Therapy. 2) Integration of Gemcitabine or Localized Irradiation into dsRNA Therapy Significantly Enhanced the Resultant Anti-tumor Activity

Creator:: Le, Uyen Minh
Abstract:: Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or...
Resource Type:: Dissertation
Full Text:: Undesirable side effects of therapeutic agents due to the lack of specificity to the site of action are one

Development of a transdermal delivery system for melatonin

Creator:: Lee, Ya-ling
Abstract:: Melatonin is an neurohormone secreted by the pineal gland. Several therapeutic possibilities for melatonin administration have been suggested. However, clinical studies with melatonin have been limited by lack of a delivery system capable of mimicking the physiological release pattern of melatonin. There is an increasing recognition that the skin can...
Resource Type:: Masters Thesis
Full Text:: the pineal gland. Several therapeutic possibilities for melatonin administration have been suggested

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Creator:: Hardardt, Elizabeth Ann
Abstract:: This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...
Resource Type:: Masters Thesis
Full Text:: successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope liquid

Novel oxylipins and heterocycles from the Rhodophyta and Cyanophyta

Creator:: Jiang, Zhi-dong
Resource Type:: Dissertation
Full Text:: 12(R), 13(S)-diHEPE or the products of a lipoxygenase system that use eicosapentaenoic acid

The natural products chemistry of the red algae Ptilota filicina and Laurencia obtusa

Creator:: Lopez, Albert
Abstract:: The sea offers a wide variety of potentially useful resources. Marine algae have been a rich source of structurally unique natural products showing diverse biological properties. The current need to develop new antifungal, antibiotic, anticancer and antiviral drugs has prompted intense research efforts into the discovery, isolation and structure determination...
Resource Type:: Masters Thesis
Full Text:: exploitation of this rich marine resource has occurred in most western cultures.35 Seaweed use has generally

Development and evaluation of an oral controlled release and a transdermal delivery system, for melatonin in human subjects

Creator:: Lee, Beom-jin
Resource Type:: Dissertation
Full Text:: oral controlled release dosage form and a transdermal dosage form of MT for use in human subjects

Prevalance [sic] of senile dementia of the Alzheimer type (SDAT) in females receiving postmenopausal conjugated estrogen vs. controls : a retrospective review

Creator:: Gooch, Michael D.
Abstract:: Recent in vitro data provide evidence that estrogen may assist in the maintenance of nervous tissue viability. Anecdotal reports suggest a lower prevalence of SDAT in postmenopausal women who have received estrogen replacement therapy although published data are conflicting. The purposes of this study are to determine whether the incidence...
Resource Type:: Masters Thesis
Full Text:: ) 24 8. Odds ratios with 95% confidence intervals for estrogen use variables for SDAT 25

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Creator:: Keller, Carol Ann
Abstract:: Acetaminophen has been safely used for analgesia for many years. Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to maintain analgesic relief in humans. Current dosing regiments are inconvenient (every 4-6 hours) and do not maintain this minimum plasma level. Simulations were conducted to examine various doses...
Resource Type:: Dissertation
Full Text:: chronic use of high doses of acetaminophen are associate with hepatic toxicity. These research was

Structural and biosynthetic studies on marine eicosanoids and other oxylipins

Creator:: Moghaddam, Mehran Fallah
Resource Type:: Dissertation
Full Text:: -lipoxygenase metabolites of arachidonic acid. These substances are currently in use as biomedicinal tools to

ScholarsArchive@OSU

Preformulation studies for oral dosage forms of lactobacilli

1) Improving the Uptake and Retention of Gadolinium in Tumors for Potential Gadolinium-Neutron Capture Therapy. 2) Integration of Gemcitabine or Localized Irradiation into dsRNA Therapy Significantly Enhanced the Resultant Anti-tumor Activity

Development of a transdermal delivery system for melatonin

The effect of ascorbate on enzymatic nitroglycerin bioactivation as measured by direct LC-MS/MS determination of nitrite

Novel oxylipins and heterocycles from the Rhodophyta and Cyanophyta

The natural products chemistry of the red algae Ptilota filicina and Laurencia obtusa

Development and evaluation of an oral controlled release and a transdermal delivery system, for melatonin in human subjects

Prevalance [sic] of senile dementia of the Alzheimer type (SDAT) in females receiving postmenopausal conjugated estrogen vs. controls : a retrospective review

Development and testing of a sustained release acetaminophen tablet for the treatment of chronic pain in osteoarthritis patients

Structural and biosynthetic studies on marine eicosanoids and other oxylipins

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