Chlamydia possesses an immense importance within both human and animal medicine when looking at pathogens. Chlamydia trachomatis infections have been shown to affect both the eye and genital tracts in millions of humans and animals every year [13]. As C. trachomatis strains are highly conserved in patients, it has made...
Our laboratory group is studying the molecular target of a novel, broad-spectrum antiviral compound known as ST-669. This compound has activity against a variety of different viruses and also obligate intracellular bacteria in the genera Coxiella and Chlamydia. The goal of this thesis project was to help elucidate the mechanism...
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Daniel Rockey
Our laboratory group is studying the molecular target of a novel, broad
Our laboratory is exploring the mechanism of action of a novel broad spectrum antiviral, ST-669. This compound has activity against a variety of different viruses and the obligate intracellular bacterium, Chlamydia. In this study, we explored the effects of ST-669 when the cell cycle of the host cells was altered....
Motivation: It can take considerable amounts of time and effort to use existing computational tools to analyze a small RNA sequence for the purpose of determining if it is characteristic of microRNA. It is similarly tedious to search for homologs to known microRNA sequences in the rapidly growing collection of...
Pantoea agglomerans pathovar betae (Pab) is a bacterium that causes galls on the roots of beet plants, resulting in reduced marketability of beet roots and crop loss. Pab uses a type III secretion system (T3SS) to infect and cause galls on beets. The T3SS is a molecular syringe-like structure that...
Chlamydia abortus, an intracellular bacterium, spreads through flocks of sheep and goats, causing ovine enzootic abortion (OAE). Chlamydiae develop within a pathogen-modified vacuole in the host cell called the inclusion, which allows the bacteria to acquire host resources. The morphology of the inclusion varies between chlamydial species. Some species fuse...
Chlamydia trachomatis is an obligate intracellular pathogen that affects millions of people worldwide via ocular or reproductive tract infection. Despite obvious differences in site of infection, there has been shown to be high levels of sequence conservation across C. trachomatis. This high level of sequence conservation is hindered with a...
Chlamydiae encode a family of proteins named the polymorphic membrane proteins, or Pmps, whose role in infection and pathogenesis is unclear. The Rockey Laboratory is studying polymorphic membrane protein expression in Chlamydia abortus, a zoonotic pathogen that causes abortions in ewes. C. abortus contains 18 pmp genes, some of which...
Chlamydia trachomatis is an obligate intracellular bacterium that causes diseases of the eye and urogenital tract in humans. It is the cause of the sexual transmitted infection (STI) chlamydia, the most prevalent STI worldwide, and the ocular disease trachoma, the leading cause of infectious blindness. To date there is no...
Background: Lateral gene transfer (LGT) among C. trachomatis strains is common, both in isolates generated in the laboratory and those examined directly from patients. This is a challenging concept because there are very few examples of recent acquisition of foreign DNA by Chlamydia spp. There is no understanding of the...