This thesis describes evaluation of a novel self-sealing chewable sustained release tablet that can maintain controlled release of drug regardless of compaction, crushing, or chewing. The new formulation contains polyethylene oxide which produces a sealant effect for cracks produced in the polymer coating during compaction. Dissolution studies were conducted and...
The effects of possible operating variables such as flow rate, surface temperature, bulk temperature, solids contents, sulfate addition and pH on the fouling of sulfite spent evaporators were studied. The study pointed out that the Ca⁺⁺ concentration difference between heated surface and bulk is the most important factor for fouling...
The infrared spectra of the metaborate monomer and trimer
ions in NaC1, KC1, and KBr were studied. These spectra contain
bands due to the trimer in solid solution, in a second phase of the appropriate
potassium or sodium salt, and perhaps on adjacent lattice
sites. Furthermore, complex equilibria exist between...
Gastric retention time of single unit dosage forms in swine was found
to be much longer than in humans. It was concluded that swine are not a
good animal model to study GI transit time of nonerodable or slowly eroded
dosage forms. Noneradable and slowly eroded dosage forms used to...
This thesis describes a project to produce controlled release ketoprofen beads for capsules, both at Oregon State University and in an industrial scale-up operation, that are bioequivalent to the commercial product Oruvail. A bead formulation was produced by layering drug and binders in water onto nonpareil sugar seeds in a...
In vivo research following ingesting of commercially available
Lactobacillus tablets, which contain about 2X10⁶ cfu/tablet of
Lactobacillus acidophilus and Lactobacillus bulgaricus cells in a dose
of four tablets daily, showed serum lipoprotein concentrations did not
change significantly. In order to increase the number of viable
Lactobacillus bacteria after challenging in...
Non-process elements are present in all kraft
recovery systems. Non-process elements are defined as
those elements which are not essential to the chemical
process, i.e., are neither active pulping chemicals (e.g.,
NaOH and Na₂S in the kraft process), nor compounds present
as a result of incomplete conversion of makeup chemicals...
This dissertation describes how to apply pharmacokinetic simulations and modeling in a clinical setting to monitor and adjust drug dosing in special patient populations. Pharmacokinetic simulations were used to investigate efficacy and risk of drug toxicity of a new dosing regimen for aminoglycoside antibiotics when administered to renal failure patients....
Black liquor recovery boilers experience significant fire-side fouling problems due to the deposition of entrained particulate matter. Increased understanding of the mechanisms by which particles deposit on these surfaces will lead to more effective management of the resultant problems. There is some evidence which suggests that the sub-micron fraction of...
The source and nature of permit value and the federal grazing fee debate motivated this dissertation research. There is little doubt that federal grazing permits have value throughout the western United States, but the source of permit value is unclear. A traditional explanation focuses on the capitalized differential between the...
This thesis describes 1) development of a gastric retention device (GRD) to
increase gastric retention time of certain drugs, 2) product formulations of an immediate
release itraconazole and controlled-release ketoprofen. GRD was fabricated from crosslinked
carbohydrate polymers. Rate and extent of hydration of the film in water and in
simulated...
This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of...
Acetaminophen has been safely used for analgesia for many years.
Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to
maintain analgesic relief in humans. Current dosing regiments are inconvenient (every
4-6 hours) and do not maintain this minimum plasma level. Simulations were
conducted to examine various doses...
Hot-melt pan-coating, which is a novel coating method and takes 2-3 hours for 300 mg coating weight gain per capsule and tamper-resistant coating, which takes 30 minutes, is much faster than tedious sugar coating and allows greater coating weight gains in shorter times than spray-melt coating. Although hot-melt pan coating...
This dissertation describes the development of a new sustained release formulation of nifedipine. The new formulation was developed by coating commercially available immediate release soft elastic gelatin capsules using a spray coating technique with two different polymeric combinations. Dissolution studies were conducted and showed that controlled release of nifedipine was...
Raw material costs and limited material availability and quality have created
significant interest in and opportunities for the application of nondestructive
evaluation techniques to improve wood processing technologies. The incentives come
from the desire to 1) manufacture the highest valued product, 2) conserve the
amount of raw material used, 3)...
Gastrointestinal (GI) transit data were collected using pigs
as animal models. Density and size effects of non-disintegrating
dosage forms on GI transit were investigated. Total GI transit
times range from 2 to 33 days for 22 administrations of these nondisintegrating
dosage forms. Pigs are found to not be an
appropriate...
The major objective of this study was to seek the reactions
of a group of supermarket managers as to what factors they felt were
necessary to a successful performance in their occupation.
One hundred eighty-four managers employed by a western-based
firm which operates stores in ten states returned questionnaires
rating...
This thesis is compromised of two distinct formulation sections, which are described below:
New compression-coated tablet formulations were developed for amoxicillin/clavulanate. Amoxicillin in an outer coat was separated from clavulanic acid in a core tablet by inactive ingredients in a middle coat. A chewable compression-coated tablet formulation with 50% stearic...
Effects of lactobacilli in enteric coated capsules
were studied in piglets (Chapter I). Lactobacillus
acidophilus and Lactobacillus bulgaricus isolated from a
commercial product were formulated in capsules, enteric
coated, and then given to both Escherichia coli-challenged
and unchallenged baby pigs. Decreased
incidence and severity of diarrhea, and decreased weight
deceleration...
The first project of this thesis is an in vitro study. This study was performed with 8 hydrocortisone topical products on the market for the purpose of comparing one Tec Lab product, a Corticool gel, to the other seven common products on the market. The permeation of these products was...
Machine vision is widely used in scientific areas and non-wood using
industries, but the extreme variability of wood has limited its adoption by forest
products industries. However, it is now becoming a key factor in further automation
of the forest products industry. As a very important part of machine vision,...
This thesis describes evaluation of a gastric retention device (GRD) developed at Oregon State University. The device was originally fabricated from Xanthan gum and Locust bean gum. A modified gastric retention device containing other additives was developed and investigated in this work. The modified device was evaluated in vitro for...
A computer program, SAW3DG, was developed to optimize log breakdown
using 3-dimensional log and internal defect shapes. The program was based on
SAW3D, a log breakdown optimization program considering only 3-dimensional log
shape. SAW3D was modified to include internal log defects in 3-dimensional
representation and integrated with SLGRADER, an expert...
Development of a novel, useful, orally administered dosage form
providing controlled, sustained release of an active ingredient was desired.
Film layers of Aquacoat and Eudragit L-30D (commercially available
coating materials) were applied to acetaminophen cores. Amount of coating
material, number of polymer layers, and order of application were varied.
In...
Four different treatments of acetaminophen were administered to
eight healthy volunteers in multiple doses (five doses). Saliva
acetaminophen concentration-time profiles were determined. Non-compartmental
pharmacokinetic parameters for the first and last dose
were calculated and compared to determine whether acetaminophen
exhibited linear or dose dependent pharmacokinetics. Dose corrected
area under the...
Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage
forms are presented in chapter one of this thesis. In vivo
single dose and multiple dose studies of two
sustained-release formulations as well as one conventional
dyphylline formulation are described in chapter two. The
pharmacokinetics of dyphylline following...
Non-destructive commercial ultrasonic grading provides laminated veneer lumber (LVL) manufacturers a means for sorting veneer based on average ultrasonic propagation time (UPT) and/or average dynamic modulus of elasticity (MOEd). While this may provide reliable estimations of modulus of elasticity (MOE), little is known about the influence of veneer defects on...
The influence of irregular terrain on the evolution of the daytime
planetary boundary layer (PBL) and meso-β scale dry circulations is
studied using two three-dimensional hydrostatic σ-coordinate models
with different approaches for the PBL parameterizations; the 4-layer
model uses the mixed-layer (bulk-layer) approach, while the 7-layer
model adopts the eddy-diffusivity...
Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
Pharmacokinetic parameters for theophylline and
dyphylline were evaluated in horse cerebrospinal fluid
(csf) and plasma. Pharmacokinetic parameters did not
differ significantly (p > 0.05) at the same dose for
either drug when administered alone or concomitantly.
Theophylline and dyphylline penetrate horse csf to
produce approximately 1/2 the concentrations found in...
This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
Dyphylline is an analogue of theophylline and the
latter is the most popular member of the methyixanthine
family in use for the treatment of asthma. Although
dyphylline is devoid of some problems associated with
theophylline, a reported short half-life for dyphylline
(2.1 hours) has made its clinical usefulness limited. In...
The stability of 1 3-bis(2-chloroethyl)-1-nitrosourea
(NSC 409962)(BCNU) was investigated in several buffered
aqueous media, in mixed solvent and in nonaqueous solvent
systems, and in the presence of several electrolytes and
nonelectrolytes. The degradation rate constant of BCNU in
these systems was calculated from the parameters of the
linear regression of...
This dissertation is comprised of four distinct formulation sections, which are described below: A novel solid dosage formulation was investigated for achieving zero-order drug release profile by combining tablet shape design and tablet membrane film coating. Verapmail (model drug) was compressed into hydrophilic matrix tablet cores of flat-faced and bi-convex...
The 2004 Indian Ocean tsunami raised concern among marine park managers and
hazard mitigation professionals about the significant impact of major coastal hazards
on marine park natural resources and ecosystems. The main reason for this concern is
the strong linkage of marine parks and their rich assortment of ecosystem services...
The relative bioavailability and pharmacodynamics
of tolbutamide from two different commercially available
tablet products has been evaluated in healthy subjects
in a single dose cross over study. Products were aged
by exposing tablets to 98% relative humidity for 3 days
at ambient temperature which was found to differentially
affect both...
This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
Earthquakes a . tsunamis pose significant threats to port and harbor
communities in the Pacific Northwest. Developing effective mitigation and
preparedness plans requires a comprehensive understanding of community
vulnerability. Research presented here focuses on the vulnerability of ports and
harbors to earthquake and tsunami hazards and includes a regional study...