Index Catalog // ScholarsArchive@OSU

Product formulation of phenylbutazone, theophylline, tolbutamide and pharmacokinetics-toxicities of theophylline injections in pigs

Creator:: Suvanakoot, Uthai
Abstract:: A two-part study was conducted with three poorly water soluble drugs (phenylbutazone, tolbutamide, theophylline) to develop two new drug delivery systems based on physical-chemical approaches. In the first part, tolbutamide and phenylbutazone were made into solid dispersions with various excipients using a lyophilization technique. In vitro dissolution studies of these...
Resource Type:: Dissertation
Full Text:: physiological availability from solid dosage forms are largely dependent upon having the drug in the dissolved

Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

Creator:: Bailey, Bonnie J.
Abstract:: Reported here is an investigation to determine if azinphos-methyl (AZM), an organophosphate insecticide, adducts to hemoglobin, and if so, whether the hemoglobin adduct could be used as a quantitative marker of occupational AZM exposure. We hypothesized that AZM, or a metabolite of AZM, binds to hemoglobin in erythrocytes forming an...
Resource Type:: Dissertation
Full Text:: physiological role for that enzyme has been defined, use of the term cholinesterase assumes AChE unless

Indole-3-carbinol and 3,3'-diindolylmethane : relative potency as modulators of drug metabolism and carcinogenesis

Creator:: Katchamart, Sirinmas
Abstract:: Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and cauliflower. I3C has been shown to have anticarcinogenic activity against many chemical carcinogens in multiple target organs in animal models. However, the anticarcinogenic activity of I3C is considered indirect since...
Resource Type:: Dissertation
Full Text:: supplementation are its estrogenic effect as seen in trout and its ability to induce cytochrome P45 Os involved

Terminal oxidation pathways in Acetobacter suboxydans

Creator:: Kitos, Paul Alan
Resource Type:: Dissertation
Full Text:: . . . . . . . . . . . . . , . 64 1. pH Effect on aueose Oxidation . . . 6 2. Nuoleotide 3pecificity of G-o-P Dehydrogenase and

Certain physiological and pharmacological effects of radiation on rabbits

Creator:: Wagelie, Edwin Gan
Abstract:: Data were taken, following irradiation exposure to 100r and 300r cumulative dose, on 89 rabbits of three breeds that vary greatly in body size. Hematological, intestinal motility, and ear vascularity examinations were performed. Least square estimates have been obtained and an analysis of variance has been conducted in order estimate...
Resource Type:: Dissertation
Full Text:: Certain Physiological and Pharmacological Effects of

Use of radiation resistant organism as a protectant from lethal effects of irradiation in mice

Creator:: Kilbourn, Joan Priscilla Payne
Resource Type:: Dissertation
Full Text:: irradiation protected some of them from a lethal dose of irradiation. The effect of extracts from the

A metabolic function of selenium, assessed with rat liver homogenates

Creator:: Bull, Richard Charles
Abstract:: In three separate trials rats were fed either a basal diet deficient in selenium and vitamin E or the same diet supplemented with one or both of these factors. In addition to these treatments in two of the trials, ethoxyquin was included to provide adequate lipid antioxidant protection and to...
Resource Type:: Dissertation
Full Text:: beneficial effect upon reproduction in the rat. Somewhat later Poley et al. (1941), also conducting a

Effects of radiation on selection progress in mice

Creator:: Womack, James Ernest
Abstract:: The effects of x-irradiation on quantitative genetic traits was investigated by comparing the response of irradiated mice to selection for litter size and 28-day weight with the response to selection for the same two traits in non-irradiated lines. Irradiated lines were maintained at three levels of x-irradiation, 25 r, 50...
Resource Type:: Dissertation
Full Text:: interaction of genetic and physiological factors was assumed to be responsible for the reduced fertility

Manganese absorption by barley roots

Creator:: Maas, E. V. (Eugene Vernon), 1936-
Abstract:: An investigation of Mn uptake by five-day-old excised barley roots revealed that a metabolically-mediated process was involved. In short-term experiments, the rate of Mn absorption was comparable to that of the macronutrient cations. Like other metabolically absorbed cations, the Mn absorption rate was a direct function of the ambient concentration...
Resource Type:: Dissertation
Full Text:: studied, Li alone had a pronounced stimulatory effect while Na, K and Rb markedly reduced the absorption

Effects of radiation on selection progress in mice

Creator:: Womack, James Ernest
Abstract:: The effects of x-irradiation on quantitative genetic traits was investigated by comparing the response of irradiated mice to selection for litter size and 28-day weight with the response to selection for the same two traits in non-irradiated lines. Irradiated lines were maintained at three levels of x-irradiation, 25 r, 50...
Resource Type:: Dissertation
Full Text:: interaction of genetic and physiological factors was assumed to be responsible for the reduced fertility

Influence of dietary selenium on the distribution of tritium-labeled vitamin E in the rate

Creator:: Cheeke, Peter R.
Abstract:: A series of four trials were conducted to determine the influence of selenium supplementation of a selenium- and vitamin E-deficient basal diet on the absorption, excretion, tissue distribution and placental transfer of a single dose of tritium-labeled α-tocopherol in the rat. In the first trial, the effect of supplementation of...
Resource Type:: Dissertation
Full Text:: the rat. In the first trial, the effect of supplementation of the basal diet with 1. 0 ppm selenium

The effect of dimethyl sulfoxide (DMSO) on the radiosensitivity of the rough-skinned newt (Taricha granulosa)

Creator:: Lappenbusch, William L.
Abstract:: More than 2,000 male newts were collected during the summer and maintained unfed at 10°C both pre- and post-irradiation. Exposures ranging up to 30 kR were given with 300 kVp X-rays and ⁶⁰Co gamma rays. Half of the newts were injected (I. P.) with 15 g DMSO/kg (the maximum sublethal...
Resource Type:: Dissertation
Full Text:: The effect of dimethyl sulfoxide (DMSO) on the

Effects of x-irradiation on DNA synthesis in salivary gland cells of Drosophila hydei

Creator:: Wong, Patrick Tin-Choi, 1942-
Abstract:: The effect of X-irradiation on DNA synthesis in larval salivary glands of Drosophila hydei was studied using the technique of liquid scintillation spectrometry and autoradiography. DNA synthesis in salivary glands of synchronized larvae was measured at successive stages of third instar development by in vitro uptake of ³H-thymidine for a...
Resource Type:: Dissertation
Full Text:: Paul A. Roberts The effect of X-irradiation on DNA synthesis in larval salivary glands of Drosophila

Temperature and the bioenergetics of Cichlasoma bimaculatum

Creator:: Sethi, Hari Singh
Abstract:: One means of evaluating the temperature requirements of an animal is to determine changes temperature causes in the uses and losses of energy and materials in the food the animal consumes. To develop energy budgets for cichlids (Cichlasoma bimaculatum) at different temperatures (20, 24, 28, 32 and 36 C) data...
Resource Type:: Dissertation
Full Text:: determines the limits within which the animal is free to perform. Some of the pertinent physiological

The uptake, retention, and distribution of ⁶⁰Co, ⁶⁵Zn, ⁸⁵Sr, and ¹³¹I in the rough-skinned newt (Taricha Granulosa) : A radio-ecological study

Creator:: Valett, Bryan Batson
Abstract:: The uptake, retention, and distribution of ⁶⁰Co, ⁶⁵Zn, ⁸⁵ Sr, and ¹³¹I was examined in the Rough-Skinned Newt (Taricha granulosa). Each of these radionuclides is a possible contaminant of the freshwater environment and, thus, is of importance in radioecology. The newts were maintained singly at 10° C in an unfed...
Resource Type:: Dissertation
Full Text:: form complexes with organic materials. Thus, cobalt is potentially useful in physiological processes

Histogenesis of fetal rat lung and liver after x-irradiation in organ culture and in utero

Creator:: Vogt, Judith C.
Resource Type:: Dissertation
Full Text:: Radiation Studies on Lung Cultures 36 Properties of Connective Tissue 38 Properties of Collagen 41 Effect of

Effects of dieldrin on the intrinsic rate of increase of the guppy, Poecilia reticulata Peters

Creator:: Roelofs, Terry Dean
Resource Type:: Dissertation
Full Text:: increase becomes more of a physiological parameter, the value of which is de- pendent upon existing

Calcium regulation and physiological function in animals exposed to lead

Creator:: Hoffman, Norbert Edward
Abstract:: Tissue distribution studies of calcium and lead in brain tissue of rats were increased subsequent to a single intravenous injection of lead, 10 mg/kg, in the form of lead acetate. Time-course studies demonstrated that brain concentrations of calcium and lead (in terms of wet tissue weight) were found to be...
Resource Type:: Dissertation
Full Text:: Calcium regulation and physiological function in animals

The effect of selenium deficiency on the fatty acid metabolism of rats and lambs

Creator:: Fischer, William Carl
Abstract:: Selenium deficiency in rats results in increased carbon metabolism, approaching twice the rate of selenium supplemented animals (normal). This is also reflected in a 50 percent increase in lysosomal enzyme activity in tissues of selenium deficient animals. Isolation of rat liver lysosomes shows a 17 percent increase in membrane thickness...
Resource Type:: Dissertation
Full Text:: , 1974 (Major Department) Title: THE EFFECT OF SELENIUM DEFICIENCY ON THE FATTY ACID METABOLISM OF RATS

Behavioral and electrophysiological evidence for the mechanisms involved in the detection of ionizing radiations by the crayfish Pacifastacus trowbridgii

Creator:: Rodriguez, Adrian
Abstract:: The light-adapted crayfish, Pacifastacus trowbridgii (Stimpson, 1957), displayed a behavioral response to exposure to 300 kV x-rays at exposure rates of 10 to 30 R/s. Within this range, the proportion of subjects that responded increased with an increase in exposure rate. The response latency was inversely proportional to the exposure...
Resource Type:: Dissertation
Full Text:: - physiological tests. The presence of chemoreceptors was indicated by responses elicited after administration of

Selenium effects and species differences in hepatic metabolism of pyrrolizidine alkaloids and other xenobiotics

Creator:: Shull, Lee R.
Abstract:: The metabolism of pyrrolizidine alkaloids and other drugs was studied with regard to nutritional status and species differences. Pyrrolizidine alkaloids which are biotransformed to severely toxic metabolites were isolated from tansy ragwort (Senecio jacobaea). Semi-purified alkaloid crystals containing five alkaloids (senecionine, seneciophylline, jacobine, jacoline, and jacozine) were prepared and found...
Resource Type:: Dissertation
Full Text:: liver weight, but had no effect on microsomal oxidases. Similarly, high copper had no effect on the

Some aspects of the mechanism of estrogen action in the uterus of the ewe

Creator:: Koligian, Karl Bruce
Abstract:: The binding of estrogen to endometrium and uterine arteries of the ewe was investigated by use of a [³H]estradiol exchange assay and by incubating whole tissue aliquants with [³ H]estradiol, a method which permits quantification of bound estrogen translocated from the cytoplasm to the nucleus. Five ewes were necropsied on...
Resource Type:: Dissertation
Full Text:: arteries on day 10 only. The effect of estrogen and progesterone on concentra- tions of estrogen

Selenium-75 incorporation in semen and reproductive organs of the bull and ram

Creator:: Pond, Finn Richard
Resource Type:: Dissertation

The influence of selenium on selenoprotein W

Creator:: Yeh, Jan-ying
Abstract:: The objective of our study was to investigate the effect of selenium on selenoprotein W. Western blot analysis indicated that selenoprotein W is present in muscle, brain, testis and spleen of rat tissues. Tissue distribution of selenoprotein W was not altered in rats fed various selenium levels. Among muscle, brain,...
Resource Type:: Dissertation
Full Text:: . Whanger The objective of our study was to investigate the effect of selenium on selenoprotein W

Purification and characterization of recombinant calpain-5

Creator:: Wang, Mei-Chuan
Abstract:: Recombinant human calpain-5 was expressed in insect cells using a baculovirus system. The expressed calpain-5 was purified by both traditional chromatography and by affinity-column chromatography. Both methods yielded active protease. Calpain-5 displayed very limited hydrophobicity. This indicated that calpain-5 is not a membrane binding protein. Calpain-5 had pI of 8.3....
Resource Type:: Dissertation
Full Text:: cysteine proteases. Although the exact physiological roles of calpains remain to be elucidated, calpains

Effects of nicotinic acid on respiratory exchange ratio and blood-borne substrate levels during exercise

Creator:: Heath, Edward M.
Resource Type:: Dissertation
Full Text:: vein. Another purpose of the study was to examine the effect of three weeks of NA ingestion on total

The distribution and transfer of zinc-65 accumulated from food and seawater by three marine crustaceans

Creator:: Fowler, Scott Wellington
Resource Type:: Dissertation
Full Text:: at night from 66 to 82% of the time. The effect of molting on the downward transfer of 65Zn during

Effects of ⁶⁰Co gamma irradiation on the reproductive performance of the brine shrimp, Artemia

Creator:: Holton, Robert L.
Abstract:: The brine shrimp, Artemia, was used as an experimental organism to study the effects of ⁶⁰Co gamma irradiation on the reproductive performance of an animal population. The total reproductive ability of the brine shrimp was fractionated into various components and the effects of irradiation on each of these components was...
Resource Type:: Dissertation
Full Text:: to the control animals. In all cases, doses of 600 rads or less showed little effect on the

The effect of food processing on the bioavailability of selenium in tuna and wheat : human and rat studies

Creator:: Alexander, Anne Rose
Abstract:: Bioavailability of selenium (Se) in processed tuna and wheat products was studied in humans and rats. The protein source of the rat diets was torula yeast with Se supplied by either raw, precooked or canned tuna, or whole wheat flour, bread or bran. Sodium selenite was used as a control....
Resource Type:: Dissertation
Full Text:: of Doctor of Philosophy in Poods and Nutrition presented on January 22, 1982 Title: The Effect of

The dynamics of ⁶⁵Zn in benthic fishes and their prey off Oregon

Creator:: Vanderploeg, Henry Alfred
Resource Type:: Dissertation
Full Text:: , is used to predict the effect of temperature on A in equation (12) (Winberg, 1956). The function

Bioenergetics and survival of chum (Oncorhynchus keta) and pink (O. gorbuscha) salmon in heated seawater

Creator:: Kepshire, Bernard Michael
Abstract:: The use of heated seawater for enhancing the culture of Pacific salmon was investigated. Food consumption rate, gross food conversion efficiency, growth rate, and survival of chum (Oncorhynchus keta) and pink (O. gorbuscha} salmon fed to satiation were determined in relation to water temperature and body weight. Both species of...
Resource Type:: Dissertation

Exercise, nutrition, and homocysteine

Creator:: Joubert, Lanae Marie
Abstract:: Exercise increases B-vitamin (B6, B12, folate) dependent metabolic reactions, especially those related to energy production and the rebuilding and repairing of muscle tissue. These same B-vitamins are also important in maintaining low blood levels of homocysteine (Hcy), a cardiovascular disease (CVD) risk factor. Hcy levels rise when the metabolism of...
Resource Type:: Dissertation
Full Text:: exercise intensity is vigorous. Research examining the effect of exercise on Hcy is limited with no

Environmental temperature and the thyroid gland involvement in fertility of male rabbits

Creator:: Oloufa, Mohamed Mohamed
Resource Type:: Dissertation
Full Text:: intermittent or continuous. The esent stiiy was cor1ucted to f ir3. out the effect 01' high onvironnnta1

Adenosine receptor modulation of seizure susceptibility in rats

Creator:: Szot, Patricia
Abstract:: Adenosine is considered to be a neuromodulator or cotransmitter in the periphery and CNS. This neuromodulatory action of adenosine may be observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA), cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine (NECA) and S-PIA were generated against PTZ seizure thresholds in the rat. The rank...
Resource Type:: Dissertation
Full Text:: observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA

Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

Creator:: Farley, Sherry Mae
Abstract:: The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
Resource Type:: Dissertation
Full Text:: and d4-PK decreased in -T-injected rats demonstrating that vitamin E’s untoward effect on vitamin K

Influence of certain chemicals on the sensitivity of rat embryos to X-irradiation

Creator:: Loawhakasetr, Pathom
Abstract:: The effect of 2-aminoethyl-2-thiopseudourea[superscript .]Br[superscript .]HBr (AET), 2-mercaptoethylamine[superscript .]HC1 (MEA) and trisodium calcium chelate of diethylenetriaminepentaacetic acid (CaNa₃DTPA) on the radiosensitivity of rat fetus was investigated. A total of 1256 fetuses were critically examined. Exposure of rats to 200 r whole-body X-irradiation at 9.5 days of gestation resulted in a...
Resource Type:: Dissertation
Full Text:: CERTAIN CHEMICALS ON THE SENSITIVITY OF RAT EMBRYOS TO X-IRRADIATION Abstract approved The effect of

Effect of x-irradiation upon glucose catabolism in the intact rat

Creator:: Marks, Darrell Lee
Abstract:: Beginning with the discovery of x-rays by Wilhelm Konrad Roentgen in 1895, man has had the capacity to greatly increase radiation levels of his environment, especially with the advent of nuclear weapons in recent years. Radioisotopes are finding progressively wider use in medicine, research, power production, etc., with increased hazards...
Resource Type:: Dissertation
Full Text:: . in Radiation Biology (Name) (Degree) (Major) Date thesis is presented fi'jAy 17 ,/9(?6 Title EFFECT

The effects of ultraviolet irradiation on the photosynthetic apparatus

Creator:: Mantai, Kenneth Edward
Abstract:: The effects of ultraviolet (UV) irradiation on photosynthesis and various partial reactions involving the individual photoreactions of photosynthesis were examined. These reactions included photo-reduction in adapted green algae, Hill reaction, cyclic photophosphorylation, the 520 nm absorbance change and variable-yield fluorescence. The reactions were measured in spinach chloroplasts and isolated chloroplasts...
Resource Type:: Dissertation
Full Text:: totally the system I portion of the absorbance change had no effect on the ability of chloroplasts iso

Reactions of the sea anemone, Anthopleura xanthogrammica, to electromagnetic radiations in the visible, ultraviolet, and X-ray ranges

Creator:: Clark, Ervil Delwyn
Abstract:: The behavioral repertoire of the sea anemone, Anthopleura xanthogrammica, was investigated to test for the occurrence of any immediate response to various regions of the electromagnetic spectrum. Monochromatic radiations in the visible and ultraviolet spectral regions were produced by a 150-watt xenon lamp or a ZOO watt mercury vapor lamp...
Resource Type:: Dissertation
Full Text:: (see for example, Millott, 1957 and 1968) little or no attention has been given to the effect of

A study of selected behavioral and electro-physiological responses of carpenter ants (Campanotus) to ionizing radiations

Creator:: Martinsen, David Linnebach, 1940-
Resource Type:: Dissertation
Full Text:: A study of selected behavioral and electro-physiological

The role of leptin in normal and pathological bone resorption

Creator:: Philbrick, Kenneth Alan
Abstract:: Particles generated from wear of prosthesis joint bearing surfaces induce inflammation and promote pathological periprosthetic osteoclast-mediated bone resorption (osteolysis). Obesity increases the risk of prosthesis failure. However, despite being morbidly obese, leptin-deficient ob/ob mice are resistant to osteolysis. These findings suggest that leptin exerts effects that act to increase particle-induced...
Resource Type:: Dissertation
Full Text:: .......................................................................................................................... 14 Study 2.2: Effect of housing temperature on particle-induced osteolysis in WT Study 2.3

Effect of environmental variables on the structure and function of hemocyanin from Callianassa californiensis (Decapoda: Thalassinidea)

Creator:: Miller, Karen Illman
Abstract:: Oxygen binding behavior and subunit association-dissociation of the hemocyanin from Callianassa are sensitive to several environmental variables. Callianassa californiensis is a burrowing estuarine which must survive changes in salinity, temperature and oxygen availability. Previous work on the structure and function of the hemocyanin was done under conditions which did not...
Resource Type:: Dissertation
Full Text:: Effect of environmental variables on the structure and

The effect of food and tablet age on the relative bioavailability and pharmacodynamics of two tolbutamide products

Creator:: Olson, Stephen Carl
Abstract:: The relative bioavailability and pharmacodynamics of tolbutamide from two different commercially available tablet products has been evaluated in healthy subjects in a single dose cross over study. Products were aged by exposing tablets to 98% relative humidity for 3 days at ambient temperature which was found to differentially affect both...
Resource Type:: Dissertation
Full Text:: conceivable that this difference in physiological effect would be magnified during glucose peak

Pharmacological characterization of the porcine atrial A₁ adenosine receptor

Creator:: Leid, Mark
Abstract:: Cardiac A₁ adenosine receptors mediate cardioinhibitory properties of adenosine and structural congeners. The objective of these studies was to increase our understanding of molecular processes involved in ligand interactions with receptors mediating cardioinhibitory effects of adenosine and the interactions of these receptors with guanine nucleotide binding regulatory proteins. Porcine atrial...
Resource Type:: Dissertation
Full Text:: I -1 Physiological effects of adenosine in various tissues and cell types 18 CHAPTER II II -1

Interactions of pyrethroid insecticides with GABAA and peripheral-type benzodiazepine receptors

Creator:: Devaud, Leslie L.
Resource Type:: Dissertation
Full Text:: ]Ro5-4864 binding to rat olfactory bulb membranes: effect of cismethrin. 16. Schild plot of

Modulation of sensory afferent processing by endogenous spinal adenosine

Creator:: Keil, Gary J.
Resource Type:: Dissertation
Full Text:: independent systems to achieve a common physiological or 10 pharmacological effect. A number of

Biochemical and molecular characteristics of selenoprotein W

Creator:: Gu, Qiu-Ping
Resource Type:: Dissertation
Full Text:: effect of substantially high selenium levels on human health was found in China, Enshi county of Hubei

Behavior of certain radionuclides in a marine benthic amphipod

Creator:: Cross, Ford A.
Resource Type:: Dissertation
Full Text:: accumulation and elimination rates were temperature dependent although the effect appeared minimal within the

Effect of ethanol and low dietary copper on perinatal and postweanling copper utilization in the rat

Creator:: Baek, Jong Ho
Abstract:: The hypotheses of this research were (1) to test if the antagonistic effect of ethanol on liver copper could be seen within a short period when ethanol ingestion, low dietary copper and high metabolic demand represented by either pregnancy plus lactation or rapid growth are simultaneously present and (2) to...
Resource Type:: Dissertation
Full Text:: physiological state (pregnancy and lactation compared to growth); and (5) to determine the effect of maternal

Some effects of thyroxine and pentachlorophenol on the bioenergetics of cichlid fish

Creator:: Pasley, James Neville
Resource Type:: Dissertation

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