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  • Generation of proof of concept molecules neutralizing monoclonal antibodies to IL17Cm

    Creator:
    Calhoun, Drew W.
    Abstract:
    Inflammation is one of the first, most important responses of the immune system when presented with infection and is mediated primarily by eicosanoids and cytokines. The goal of this research was to generate monoclonal antibodies against murine IL17C, a poorly characterized cytokine involved in inflammation and linked to inflammatory conditions....
    Resource Type:
    Honors College Thesis
    Full Text:
    Kevin Ahern Inflammation is one of the first, most important responses of the immune system when

  • Validation of early predictors of outcome in the Dallas Newborn Cohort

    Creator:
    Lee, Nancy Jade
    Abstract:
    Sickle cell disease (SCD) is a phenotypically variable disorder of hemoglobin that leads to abnormally shaped and dysfunctional red blood cells. Several studies have attempted to construct early predictive models for SCD, including Miller et al.’s (2000) model which uses easily identifiable predictors in early life. The primary aim of...
    Resource Type:
    Honors College Thesis

  • Investigation of the roles of viral proteinases in the vaccinia virus life cycle

    Creator:
    Page, Jessica M.
    Abstract:
    An inducible, mutant virus, designated vvtetO:I7L/G1L, was used to study the morphogenic proteolysis step of the vaccinia virus life cycle. The vvtetO:I7L/G1L controlled the expression of two genes, I7L, a cysteine proteinase, and G1L, a putative metalloproteinase. These proteins are involved in the maturation of viral core proteins, p4a, p4b,...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Kevin Ahern for their efforts toward helping me produce and write this project. I would like to give a

  • Investigating the age-related loss of endoplasmic reticulum stress response

    Creator:
    Fallahi, Anahita
    Abstract:
    The endoplasmic reticulum (ER) is a crucial organelle in the cell where protein folding and processing occurs, and conditions that negatively affect ER functions are highly detrimental to the cell. The accumulation of unfolded/misfolded proteins in the ER leads to a condition known as ER Stress. The ER has developed...
    Resource Type:
    Honors College Thesis
    Full Text:
    the ER contain stretches of hydrophobic N-terminal signal sequences which attract the binding of a

  • Design for construction safety : a case study with architect's perceptions

    Creator:
    Christianson, Carl R.
    Abstract:
    Designing for construction safety is a collaborative process that combines the field experience of builders with the design skills of architects to improve construction safety. Research studies have shown that the design of a project is a factor in approximately fifty percent of jobsite deaths. To reduce this problem it...
    Resource Type:
    Honors College Thesis
    Full Text:
    alone… we can bring a lot to the table. Kevin, Jim, and Mina have hands-on, field experience that lets

  • A genomic and proteomic characterization of the first cultured oligotrophic marine Gammaproteobacterium from the SAR92 clade

    Creator:
    Mellbye, Brett L.
    Abstract:
    High-throughput culturing (HTC) consisting of extinction culturing in autoclaved seawater has led to the isolation and characterization of many novel strains of oligotrophic marine bacteria. Strain HTCC 2207 was isolated from the Oregon coast by the HTC method. Phylogenetic analysis based on 16S rRNA gene sequence showed that this strain...
    Resource Type:
    Honors College Thesis
    Full Text:
    A Genomic and Proteomic Characterization of the

  • Investigating the Role of the MutLα Endonuclease

    Creator:
    Mankaney, Gautam Naresh
    Abstract:
    Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
    Resource Type:
    Honors College Thesis
    Full Text:
    individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their

  • Exploring phylogeny of Rhodococcus fascians isolates using 16S ribosomal DNA sequence analysis

    Creator:
    Sandberg, Eva Song
    Abstract:
    Rhodococcus fascians is a Gram-positive, pleiomorphic actinomycete that causes leafy gall formation in a wide range of plant hosts. This particular phytopathogen has been a focus of research at the Oregon State University Plant Clinic, a diagnostic laboratory. Phylogeny of R. fascians isolates obtained from Plant Clinic submissions was determined...
    Resource Type:
    Honors College Thesis
    Full Text:
    Melodie Putnam Rhodococcus fascians is a Gram-positive, pleiomorphic actinomycete that causes leafy gall

  • Aging and oxidative damage to mitochondrial membrane proteins

    Creator:
    Tong, Tony T.
    Abstract:
    Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
    Resource Type:
    Honors College Thesis
    Full Text:
    this process is also a source of oxygen radicals that are capable of damaging nearby proteins

  • Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

    Creator:
    O'Donnell, Edmond Francis
    Abstract:
    DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
    Resource Type:
    Honors College Thesis
    Full Text:
    . Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a