Index Catalog // ScholarsArchive@OSU

Generation of proof of concept molecules neutralizing monoclonal antibodies to IL17Cm

Creator:: Calhoun, Drew W.
Abstract:: Inflammation is one of the first, most important responses of the immune system when presented with infection and is mediated primarily by eicosanoids and cytokines. The goal of this research was to generate monoclonal antibodies against murine IL17C, a poorly characterized cytokine involved in inflammation and linked to inflammatory conditions....
Resource Type:: Honors College Thesis
Full Text:: Kevin Ahern Inflammation is one of the first, most important responses of the immune system when

Investigating the age-related loss of endoplasmic reticulum stress response

Creator:: Fallahi, Anahita
Abstract:: The endoplasmic reticulum (ER) is a crucial organelle in the cell where protein folding and processing occurs, and conditions that negatively affect ER functions are highly detrimental to the cell. The accumulation of unfolded/misfolded proteins in the ER leads to a condition known as ER Stress. The ER has developed...
Resource Type:: Honors College Thesis
Full Text:: . 15 m R N A C H O P/ β- A ct in Young Old N.S . ** * N.S . N.S . * 0 4 12 24

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

Creator:: Page, Jessica M.
Abstract:: An inducible, mutant virus, designated vvtetO:I7L/G1L, was used to study the morphogenic proteolysis step of the vaccinia virus life cycle. The vvtetO:I7L/G1L controlled the expression of two genes, I7L, a cysteine proteinase, and G1L, a putative metalloproteinase. These proteins are involved in the maturation of viral core proteins, p4a, p4b,...
Resource Type:: Honors College Thesis
Full Text:: THESIS OF Jessica M. Page for the degree of Honors Baccalaureate of Science in Biochemistry and

A genomic and proteomic characterization of the first cultured oligotrophic marine Gammaproteobacterium from the SAR92 clade

Creator:: Mellbye, Brett L.
Abstract:: High-throughput culturing (HTC) consisting of extinction culturing in autoclaved seawater has led to the isolation and characterization of many novel strains of oligotrophic marine bacteria. Strain HTCC 2207 was isolated from the Oregon coast by the HTC method. Phylogenetic analysis based on 16S rRNA gene sequence showed that this strain...
Resource Type:: Honors College Thesis
Full Text:: thanks to Kevin Vergin, Sarah Sowell, Dr. Ulrich Stingl, and Jim Tripp for devoting so much of their time

Aging and oxidative damage to mitochondrial membrane proteins

Creator:: Tong, Tony T.
Abstract:: Mitochondria provide energy for biological cells to function, but this process is also a source of oxygen radicals that are capable of damaging nearby proteins. Mitochondrial protein damage can eventually lead to cell death, especially in the case of heart cells, where mitochondria are present in the highest concentrations. As...
Resource Type:: Honors College Thesis
Full Text:: bundle of appreciation goes out to Dr. Kevin Ahern. He has done so much for me and his many other

Exploring phylogeny of Rhodococcus fascians isolates using 16S ribosomal DNA sequence analysis

Creator:: Sandberg, Eva Song
Abstract:: Rhodococcus fascians is a Gram-positive, pleiomorphic actinomycete that causes leafy gall formation in a wide range of plant hosts. This particular phytopathogen has been a focus of research at the Oregon State University Plant Clinic, a diagnostic laboratory. Phylogeny of R. fascians isolates obtained from Plant Clinic submissions was determined...
Resource Type:: Honors College Thesis
Full Text:: Tzanetakis Dr. Aaron Liston Eric Hill Rebekah Lancelin Dr. Kevin Ahern Dr. Terri Fiez Molly Elliot

Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

Creator:: O'Donnell, Edmond Francis
Abstract:: DNA mismatch repair (MMR) is an evolutionary conserved process that functions to maintain genomic integrity through the correction of mismatches that have escaped proofreading. Mutations in the MMR gene Mlh1 are associated with approximately 50% of all cases of Lynch syndrome, a hereditary predisposition to colorectal cancer, through varying and...
Resource Type:: Honors College Thesis
Full Text:: collection, to Pete Hoffman for supplying the pRO1 plasmid construct, and to Kevin Ahern for his for his

Investigating the Role of the MutLα Endonuclease

Creator:: Mankaney, Gautam Naresh
Abstract:: Lynch individuals have a predisposition to developing colorectal and other cancers due to inherited defects in their mismatch repair (MMR) system. Although mutations in MMR have been directly implicated in Lynch Syndrome, the precise mechanism(s) of MMR functions have yet to be elucidated. One essential complex, MutL (a dimer of...
Resource Type:: Honors College Thesis
Full Text:: mothering me throughout my research experience, and Kevin Ahern for his advice and encouragement. Finally

Design for construction safety : a case study with architect's perceptions

Creator:: Christianson, Carl R.
Abstract:: Designing for construction safety is a collaborative process that combines the field experience of builders with the design skills of architects to improve construction safety. Research studies have shown that the design of a project is a factor in approximately fifty percent of jobsite deaths. To reduce this problem it...
Resource Type:: Honors College Thesis
Full Text:: alone… we can bring a lot to the table. Kevin, Jim, and Mina have hands-on, field experience that lets

The application of geographic information systems for delineation and classification of tidal wetlands for resource management of Oregon’s coastal watersheds

Creator:: Scranton, Russell W.
Abstract:: Resource managers of Oregon’s tidal wetlands require an improved GIS layer for management of existing tidal wetland habitat and areas considered for tidal wetland restoration. A reconnaissance project was initiated, such that interpretations of remote sensing data, the National Wetland Inventory, Oregon Estuary Plan Book and additional management tools were...
Resource Type:: Capstone Project

ScholarsArchive@OSU

Generation of proof of concept molecules neutralizing monoclonal antibodies to IL17Cm

Investigating the age-related loss of endoplasmic reticulum stress response

Investigation of the roles of viral proteinases in the vaccinia virus life cycle

A genomic and proteomic characterization of the first cultured oligotrophic marine Gammaproteobacterium from the SAR92 clade

Aging and oxidative damage to mitochondrial membrane proteins

Exploring phylogeny of Rhodococcus fascians isolates using 16S ribosomal DNA sequence analysis

Pathogenic Mechanisms of Cancer Causing hMLH1 Mutations

Investigating the Role of the MutLα Endonuclease

Design for construction safety : a case study with architect's perceptions

The application of geographic information systems for delineation and classification of tidal wetlands for resource management of Oregon’s coastal watersheds

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