Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...
Anadromous Oncorhynchus mykiss (steelhead) express diverse migratory behaviors and life history strategies. Adult migration timing diversity within steelhead is often categorized into divergent early- and late-migration phenotypes. On the Rogue River in Oregon, adult steelhead return from the ocean during distinct early-summer, late-summer, and winter runs. Additionally, some juvenile steelhead...
Research relying on remotely sensed data on land use and deforestation has exploded in recent years. While satellite-based measures have clear advantages in terms of coverage, the presence of measurement error within these products is often overlooked. Here, we detail the econometric implications of these errors when analyzing the determinants...
Desferrioxamine B (DFOB) was reversibly and covalently conjugated to polystyrene microspheres via N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP) crosslinker. DFOB retained post-immobilization activity with at least 89% able to bind Fe(III)-citrate under pH 7.4 and a citrate:iron molar ratio = 100:1. Comparing iron capture by DFOB-activated beads and sulfhydryl (−SH) control beads demonstrated...
In taking a multidimensional approach to selected areas of the much neglected sport marriage, this article identifies and examines the survival strategies used by wives in coping with stressful occupational events in the careers of their husbands. Using a control management perspective, the idea of control work is introduced and...
Research on dog social cognition has received widespread attention. However, the vast majority of this research has focused on dogs’ relationships and responsiveness towards adult humans. While little research has considered dog–child interactions from a cognitive perspective, how dogs perceive and socially engage with children is critical to fully understand...
Phytochemicals from cruciferous vegetables, such as broccoli, contain a multitude of bioactive compounds that prevent and suppress cancer and promote optimal health. Some of the health promoting effects of cruciferous vegetables are attributed to a class of compounds known as isothiocyanates (ITCs), a potent nuclear factor erythroid 2–related factor 2...
True learning happens when we try new things - when we practice something, see how it goes, and then try it again. Pedagogical practices that encourage metacognition and active reflection are built on this premise. But these practices take time, and university instructors are pressured to cover as much content...
Physical activity is important for health. However, there is a lack of literature related to the physical activity levels of adults living in urban villagers, which is a vulnerable population in China. The aim of this study is to compare the physical activity and sedentary behavior engagements between urban villagers...
Salmonid fish raised in hatcheries often have lower fitness (number of returning adult offspring) than wild fish when both spawn in the wild. Body size at release from hatcheries is positively correlated with survival at sea. So one explanation for reduced fitness is that hatcheries inadvertently select for trait values...