Index Catalog // ScholarsArchive@OSU

Optimizing Methods to Assess Nanoparticle Biodistribution in Embryonic Zebrafish

Creator:: Pfarr, Shaylin H.
Abstract:: As nanoparticle (NP) research and development expands, the significance of NP biodistribution effects on toxicity increases. A reliable method for measuring NP biodistribution is critical. Hyperspectral Imaging (HSI) is capable of accurately quantitating NP biodistribution within embryonic zebrafish with incredibly high precision. Before HSI processing, the embryo must be sectioned...
Resource Type:: Honors College Thesis
Full Text:: : _____________________________________________________ Stacey Harper As nanoparticle (NP) research and development expands, the significance

Environmental Transformations of Nanoparticles in Natural Water Systems using a Hydrophobic and Hydrophilic Dye Assay

Creator:: Turnquist, Macklin C.
Abstract:: Nanoparticles (NPs) are generally defined as particles <100 nanometers (nm) in size in one dimension. Despite increasing industrial usage of TiO2 NPs in sunscreens, cosmetics, and water remediation little is known of their environmental behavior. The primary goal of this research was to develop a rapid method for determining the...
Resource Type:: Honors College Thesis
Full Text:: . Abstract approved:_____________________________________________________ Stacey L. Harper

Addressing Persistent Challenges in Nanotoxicology Exposures : Techniques for in situ Characterization

Creator:: Crandon, Lauren E.
Abstract:: Nanoparticles (NPs), defined by their size (1-100 nm), are increasingly incorporated into commercial and industrial products due to their high surface area and unique properties. They can be designed for specific applications by manipulating composition, size, shape, and surface functionalization. As NP production and complexity increases, there is a need...
Resource Type:: Dissertation
Full Text:: Abstract approved: Stacey L. Harper Nanoparticles (NPs), defined by their size (1-100 nm), are

Method development for characterizing the hydrophobicity of engineered nanoparticles

Creator:: Lee, Fang Yu
Abstract:: Characterizing the hydrophobicity of nanoparticles can help us understand their fate and transport in the environment, as well as how nanoparticles may interact with biological systems. However, contact angle and partition coefficient have limitations in measuring the hydrophobicity of nanoparticles, thus promising methods to measuring the hydrophobicity of nanoparticles are...
Resource Type:: Masters Thesis
Full Text:: Stacey L. Harper Characterizing the hydrophobicity of nanoparticles can help us understand their

Analyzing the use of the acellular DCFH assay as a means of determining oxidative stress induced in zebrafish embryos exposed to lanthanide oxide nanoparticles

Creator:: Engstrom, Arek
Abstract:: The ability of nanoparticles (NPs) to induce oxidative stress on organisms has been linked to NP cytotoxicity and genotoxicity for a variety of organisms. One proposed mechanism of this increased oxidative stress is the ability of NPs to generate reactive oxygen species (ROS). Due to the dynamic nature and small...
Resource Type:: Honors College Thesis
Full Text:: approved:_____________________________________________________ Stacey L. Harper The ability of

Studies on effect of stabilizers, chelators and inherent periodicity on nanoparticle antioxidant activity

Creator:: Zhou, Zheng
Abstract:: The level of reactive oxygen species (ROS) is tightly regulated in biological systems as overproduction can lead to oxidative stress and result in a number of diseases. Due to its negative effects, antioxidants are studied and used against ROS in medicine, pharmaceuticals and therapeutics. Because of issues with the uptake...
Resource Type:: Masters Thesis
Full Text:: Abstract approved: ______________________________________________________ Stacey L. Harper The

Heteroaggregation between citrate-stabilized gold nanoparticles and hematite colloids : mechanisms and quantification of nanoparticle-colloid interactions

Creator:: Smith, Brian M.
Abstract:: Understanding the aggregation behavior of engineered nanomaterials (ENMs) in aqueous environments is essential to understanding their fate, transport, and toxicity. Because naturally occurring colloids will likely be present at much higher concentrations than ENMs in environmental systems, heteroaggregation and attachment with these natural colloids could significantly influence ENM fate and...
Resource Type:: Masters Thesis
Full Text:: of laboratory resources by Dr. Stacey Harper and Dr. Christine Kelly. Conversations with Ed

Rational vaccine development 1) Design of a Triantigen Nasal Anthrax Vaccine Candidate 2) A Novel Lecithin Based Nanoparticle as a Vaccine Delivery System

Creator:: Sloat, Brian R.
Abstract:: Currently, the only anthrax vaccine licensed for human use in the United States is the Anthrax-vaccine-absorbed (AVA or Biothrax®). AVA suffers from several drawbacks, including a complicated and lengthy dosing schedule that requires six initial injections administered over eighteen months, followed by annual boosters. Therefore, a new generation anthrax vaccine...
Resource Type:: Dissertation
Full Text:: that contains a truncated PA (rPA63), the anthrax lethal factor (LF), and the capsular poly-γ-D

Comparison of Experimentally-determined and Model-estimated Attachment Efficiency for Predicting Nanoparticle Aggregation

Creator:: Kennard, Jasmin J.
Abstract:: The widespread use of engineered nanoparticles (ENPs) in industrial applications and consumer products makes their release to the environment inevitable. Understanding the aggregation behavior of ENPs is crucial to understanding their fate, transport and toxicology in aquatic systems. This study investigated the comparability of experimentally-determined and model-estimated attachment efficiencies for...
Resource Type:: Honors College Thesis
Full Text:: learning but also a place of friendship. Thank you to Bryan Harper and Dr. Stacey Harper for the use of

ScholarsArchive@OSU

Optimizing Methods to Assess Nanoparticle Biodistribution in Embryonic Zebrafish

Environmental Transformations of Nanoparticles in Natural Water Systems using a Hydrophobic and Hydrophilic Dye Assay

Addressing Persistent Challenges in Nanotoxicology Exposures : Techniques for in situ Characterization

Method development for characterizing the hydrophobicity of engineered nanoparticles

Analyzing the use of the acellular DCFH assay as a means of determining oxidative stress induced in zebrafish embryos exposed to lanthanide oxide nanoparticles

Studies on effect of stabilizers, chelators and inherent periodicity on nanoparticle antioxidant activity

Heteroaggregation between citrate-stabilized gold nanoparticles and hematite colloids : mechanisms and quantification of nanoparticle-colloid interactions

Rational vaccine development 1) Design of a Triantigen Nasal Anthrax Vaccine Candidate 2) A Novel Lecithin Based Nanoparticle as a Vaccine Delivery System

Comparison of Experimentally-determined and Model-estimated Attachment Efficiency for Predicting Nanoparticle Aggregation

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