Tumor necrosis factor alpha (TNF α) and interferon gamma (IFN γ) were initially recognized as inflammatory mediators produced by immune cells in response to infectious agents or foreign material. (1,5) However, over the past decade much research in mammalian species has indicated that these proteins also play key roles in...
Previous work (Thorgaard, G. H. et al., Aquatic Toxicology 46:121-126, 1999)
showed triploid rainbow trout (0. mykiss) given embryonic carcinogen bath exposures
had significant reduction of induced tumors relative to diploids. In the present study,
trout were made triploid by thermal shock after fertilization. At age of 5 months they...
Eight spontaneous orocutaneous papillomas of adult, wild-caught brown bullheads Ictalurus
nebulosus and 4 anatomically matching control tissue samples were examined by electron
microscopy. Ultrastructural characteristics of normal and neoplastic Malpighian epithelial cells were
compared and neoplastic cells were described. Normal Malpighian epithelial cells of brown bullheads
were similar to those...
During the past decade the zebrafish has emerged as a leading model for mechanistic cancer
research due to its sophisticated genetic and genomic resources, its tractability for tissue
targeting of transgene expression, its efficiency for forward genetic approaches to cancer model
development, and its cost-effectiveness for enhancer and suppressor screens...
Here we report a new transgenic expression system by combination of liver-specific expression, mifepristone induction and Cre-loxP recombination to conditionally control the expression of oncogenic kras[superscript]V12. This transgenic system allowed expression of kras[superscript]V12 specifically in the liver by a brief exposure of mifepristone to induce permanent genomic recombination mediated by...
Hepatocellular carcinoma (HCC) is currently one of the top lethal cancers with an increasing trend. Deregulation of MYC in HCC is frequently detected and always correlated with poor prognosis. As the zebrafish genome contains two differentially expressed zebrafish myc orthologs, myca and mycb, it remains unclear about the oncogenicity of...
Chordomas are uncommon neoplasms arising from notochord remnants, most commonly
occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and
primary intestinal chordomas have not been reported. Herein we report 24 cases of spontaneous
primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas....
The “Cayuga syndrome” is a maternally transmitted, naturally occurring thiamine deficiency that causes 100% mortality of larval landlocked Atlantic salmon Salmo salar in several of New York's Finger Lakes, Results of multiyear studies to qualify and quantify the neurobehavioral and gross pathological signs of this condition are described, Affected sac...
The zebrafish (Danio rerio) is emerging as a new important species for studying brain mechanisms and its deficits. Focusing on selected CNS disorders (brain cancer, epilepsy and anxiety) and using them as examples, we discuss the value of zebrafish models in translational neuroscience, and their contribution to neuroimaging, circuit-level and...
A maternally transmitted, noninfectious disease known as the Cayuga syndrome caused 100% mortality in larval offspring of wild-caught landlocked Atlantic salmon Salmo salar from several of New York's Finger Lakes. Survival of lake trout Salvelinus namaycush from Lakes Erie and Ontario was also impaired, but not until yolk absorption was...