Index Catalog // ScholarsArchive@OSU

Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy

Creator:: Taratula, Olena, Schumann, Canan, Duong, Tony, Taylor, Karmin L., and Taratula, Oleh
Abstract:: Multifunctional theranostic platforms capable of concurrent near-infrared (NIR) fluorescence imaging and phototherapies are strongly desired for cancer diagnostic and treatment. However, integration of separate imaging and therapeutic components into nanocarriers results in complex theranostic systems with limited translational potential. A single agent-based theranostic nanoplatform, therefore, was developed for concurrent NIR...
Resource Type:: Article
Full Text:: Fluorescence Imaging and Combinatorial Anticancer Phototherapy Olena Taratula, Canan Schumann, Tony Duong

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release

Creator:: Dani, Raj K., Schumann, Canan, Taratula, Olena, and Taratula, Oleh
Abstract:: Herein, we report the successful development of a novel nanosystem capable of an efficient delivery and temperature-triggered drug release specifically aimed at cancer. The water-soluble 130.1 ± 0.2 nm iron oxide nanoparticles (IONPs) were obtained via synthesis of a monodispersed iron oxide core stabilized with tetramethylammonium hydroxide pentahydrate (TMAOH), followed...
Resource Type:: Article
Full Text:: Release Dani, R. K., Schumann, C., Taratula, O., & Taratula, O. (2014). Temperature-tunable iron oxide

Advancing Nanotechnology for Photoacoustic Imaging

Creator:: St Lorenz, Anna
Abstract:: Curbing overall disease burden with faster intervention requires early stage and accurate diagnostics. Ultrasound (US) provides a safe, nonionizing, inexpensive, and noninvasive imaging modality that has become commonplace in diagnostics. Paired with the relatively new technology of photoacoustic imaging (PAI), optical level resolution becomes feasible with the deeper signal penetration...
Resource Type:: Dissertation
Full Text:: Pharmacy, The Department of Pharmaceutical Sciences and my thesis committee: Dr. Oleh Taratula, Dr. Olena

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Creator:: Schumann, Canan B.
Abstract:: Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of intervention. However, these therapeutic...
Resource Type:: Dissertation
Full Text:: his amazing wife Dr. Olena Taratula. Thank you for being there for me and letting me bounce ideas

Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

Creator:: Albarqi, Hassan Ahmad M.
Abstract:: Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
Resource Type:: Dissertation
Full Text:: like to thank Dr. Oleh Taratula and his amazing wife Dr. Olena Taratula for their advice, guidance

Non-viral Vectors for Ocular Gene Delivery

Creator:: Herrera-Barerra, Marco, F.
Abstract:: Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
Resource Type:: Dissertation
Full Text:: . Oleh Taratula and Dr. Conroy Sun provided input during for manuscript finalization. Dr. Gaurav

Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

Creator:: Sabei, Fahad Yahya
Abstract:: Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...
Resource Type:: Dissertation
Full Text:: Writing by Fahad Yahya I. Sabei, with editing and revision by Dr. Oleh Taratula and Olena Taratula

Multifunctional Nanomedicine Platform for Concurrent Delivery of Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells

Creator:: Taratula, Olena, Dani, Raj Kumar, Schumann, Canan, Xu, Hong, Wang, Andrew, Song, Han, Dhagat, Pallavi, and Taratula, Oleh
Abstract:: A multifunctional tumor-targeting delivery system was developed and evaluated for an efficient treatment of drug-resistant ovarian cancer by combinatorial therapeutic modality based on chemotherapy and mild hyperthermia. The engineered iron oxide nanoparticle (IONPs)-based nanocarrier served as an efficient delivery vehicle for doxorubicin and provided the ability to heat cancer cells...
Resource Type:: Article
Full Text:: Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells Author: Olena Taratula Raj Kumar Dani Canan

ROS-Induced Nanotherapeutic Approach for Ovarian Cancer Treatment Based on the Combinatorial Effect of Photodynamic Therapy and DJ-1 Gene Suppression

Creator:: Schumann, Canan, Taratula, Olena, Khalimonchuk, Oleh, Palmer, Amy L., Cronk, Lauren M., Jones, Carson V., Escalante, Cesar A., and Taratula, Oleh
Abstract:: This study represents a novel approach for intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells. To assess the potential of the developed therapy, dendrimer-based...
Resource Type:: Article
Full Text:: , PharmD a , Olena Taratula, PhD a , Oleh Khalimonchuk, PhD b , Amy L. Palmer, MS c , Lauren M. Cronk

Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy

Creator:: Taratula, Olena, Patel, Mehulkumar, Schumann, Canan, Naleway, Michael A., Pang, Addison J., He, Huixin, and Taratula, Oleh
Abstract:: We report a novel cancer-targeted nanomedicine platform for imaging and prospect for future treatment of unresected ovarian cancer tumors by intraoperative multimodal phototherapy. To develop the required theranostic system, novel low-oxygen graphene nanosheets were chemically modified with polypropylenimine dendrimers loaded with phthalocyanine (Pc) as a photosensitizer. Such a molecular design...
Resource Type:: Article
Full Text:: imaging-guided combinatorial phototherapy Taratula, O., Patel, M., Schumann, C., Naleway, M. A., Pang, A

ScholarsArchive@OSU

Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy

Temperature-Tunable Iron Oxide Nanoparticles for Remote-Controlled Drug Release

Advancing Nanotechnology for Photoacoustic Imaging

A Nanoparticle Mediated Gene Silencing Approach for the Treatment of Metastatic Ovarian Cancer

Systemically Delivered Magnetic Hyperthermia for Cancer Treatment

Non-viral Vectors for Ocular Gene Delivery

Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

Multifunctional Nanomedicine Platform for Concurrent Delivery of Chemotherapeutic Drugs and Mild Hyperthermia to Ovarian Cancer Cells

ROS-Induced Nanotherapeutic Approach for Ovarian Cancer Treatment Based on the Combinatorial Effect of Photodynamic Therapy and DJ-1 Gene Suppression

Phthalocyanine-loaded graphene nanoplatform for imaging-guided combinatorial phototherapy

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