Graduate Thesis Or Dissertation
 

Advancing Nanotechnology for Photoacoustic Imaging

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/kd17d130g

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  • Curbing overall disease burden with faster intervention requires early stage and accurate diagnostics. Ultrasound (US) provides a safe, nonionizing, inexpensive, and noninvasive imaging modality that has become commonplace in diagnostics. Paired with the relatively new technology of photoacoustic imaging (PAI), optical level resolution becomes feasible with the deeper signal penetration of US signal. Additionally, the application of PAI capable contrast agents creates an opportunity for disease-specific molecular level characterization that supports structural level US imaging. Herein, we advance this research by developing a library of cyanine-based derivatives within polymeric nanoparticle formulations (NPs) to study the relationship between chemical modifications of the dyes and the photophysical properties of the NPs. The PAI capability and photostability were characterized as well as the potential for image-guided photothermal therapy (PTT). Moving forward, we pursued PAI signal accuracy by synthesizing NPs with distinguishable PAI spectra from endogenous background signal. A dual-peak system with attractive PAI properties such as narrow spectral peaks and high extinction coefficients was constructed, and the distinctive signature was successfully applied in in-vitro and in-vivo ovarian cancer models. These developments in PAI-capable NPs support the ongoing progress of advancing PAI technology and its use in early-stage, point-of-care diagnostics.
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  • Intellectual Property (patent, etc.)
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  • 2021-06-12 to 2023-07-12

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