T cells are one of the key cells in the immune system. Although they are not the first line of defense against a pathogen, their functions can greatly enhance the phagocytosis and destruction of pathogens as well as the development of antibody responses. Furthermore, even when responding T cells have...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Although IL-4 is a well-characterized multi-functional cytokine, its role as a survival factor in T cells is not completely understood. In an attempt to uncover IL-4-mediated survival, we studied caspase activation in primary mouse T lymphocytes undergoing death by neglect, activation-induced or steroid-induced cell death. Here, we identify the executioner...
The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
The search for the stand density that optimizes growth and hence generates the maximum amount of wood is one of the philosopher’s stone in modern forestry. Since scientific methods were applied to forestry, numerous generations of foresters have studied the relations between stocking density and growth, obtaining diverse results and...
My thesis explores the later work of author J.D. Salinger, including two narratives featured in Nine Stories, "A Perfect Day for Bananafish," and "Teddy," and Franny and Zooey, "Raise High the Roof Beam, Carpenters," and "Seymour: an Introduction." Through my analysis I argue that the religious nature of Salinger's fiction...
This study quantified the magnitude and timing of summer streamflow deficits in paired-watershed experiments in the Cascade Range of Oregon where mature and old-growth conifer forests were subjected to clearcutting, patch cutting, and overstory thinning treatments in the 1960s and 1970s. Hydrologic effects of clearcutting, small-patch cutting, and overstory thinning...
Small mountainous watersheds are disproportionate sources of land-derived particulate organic matter (POM) to long-term sinks like lake bottoms and the ocean. As such, these ecosystems are an essential component of the global carbon cycle. The burial of POM in lacustrine and marine sediments contributes to the drawdown of atmospheric CO2...
Maximal aerobic capacity (V̇O₂max) is the most widely used measure for assessing cardiorespiratory fitness. It is a strong contributor to performance in endurance sports, predicts functional capacity in older adults, and is related to overall disease risk. As such, it is important that testing methodologies for determining V̇O₂max provide valid...
Parasitic infections and immune challenges can affect host reproductive fitness and, ultimately, the evolution of host populations in a myriad of ways. The fitness implications of parasitic infections range from increased host mortality to subtle changes in reproductive investment. From alterations of behaviors, sexual signaling, and competitive ability to changes...
Strong tidal currents experienced at Keystone Harbor, WA, have caused navigational hazards and disrupted ferry service in the area. This thesis presents details of the design, construction and implementation of a large scale physical model of Keystone Harbor used to evaluate the effectiveness of proposed jetty design alternatives to improve...
The diffusion of divalent nickel (Ni²⁺) from wet silica gels was investigated.
Silica gel is gaining interest as an encapsulation matrix for biological components.
The transport of biologically relevant species within the gel is determined by the
structural characteristics of the gel, which are in turn governed by synthesis
parameters....
Thermochemical water splitting cycles have been conceptualized and researched for over half a century, yet to this day none are commercially viable. The heavily studied Sulfur-Iodine cycle has been stalled in the early development stage due to a difficult HI-H₂O separation step and material compatibility issues. In an effort to...
A simple Janus-type membrane-based wicking microfluidic device fabricated on a polycaprolactone-filled glass microfiber membrane enables separation and collection of blood plasma or serum from whole blood. This device bridges the wicking and cut-capillary-based solution transport mechanisms in a single membrane. The initial portion of the device is fabricated using selective...
This capstone project is presented for completion of Oregon State University’s (OSU) Master of Natural Resources Program. This project is an expansion of the author’s research completed as part of the Water Conflict Management and Transformation Certificate and as part of the overall Master of Natural Resources Program.
Located on...
With the increasing international focus on transboundary cooperation as a part of the Sustainable Development Goal (SDG) Framework, there is global recognition of transboundary water cooperation as a tool for improved governance and management of transboundary surface and groundwaters. Yet, there is not an agreed upon definition of transboundary water...
Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. In this thesis, we studied the formation and modification of the nonproteinogenic amino acid enduracididine (End), which exists in two important antibiotics, mannopeptimycins (MPPs) and enduracidin.
Sequence analysis of the MPP gene cluster revealed that the product of...
Sediment deposit ages inferred from radiocarbon dating of stream bank material were used to estimate residence times of valley-floor deposits in headwater valleys of the Oregon Coast Range, USA. Inherited ages of radiocarbon-dated material, i.e., time between carbon fixation in wood and its incorporation in a sediment deposit, can result...
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Stephen T. Lancaster
Sediment deposit ages inferred from radiocarbon dating of stream bank
Rainfall interception is a primary control over the moisture input to a forested ecosystem through the partitioning of precipitation into throughfall, stemflow, and an evaporated component (i.e. the interception loss). Rainfall interception is a spatially and temporally varying process at multiple scales, but heterogeneity in interception processes are poorly understood...
Compassion fatigue is a common struggle that helping professionals face; however, it is not yet well understood in early childhood teachers. Compassion fatigue results from caring for individuals who have had traumatic experiences, which can cause physical and emotional exhaustion, leading to a diminished ability to empathize with individuals in...
Uveitis is a serious ophthalmological disorder characterized by intraocular infiltration of inflammatory cells. In most cases, uveitis is derived from the adaptive immune response. More specifically, CD4+ T lymphocytes play an important role in the pathogenesis of uveitis by recognizing uveitogenic antigen and orchestrating the immune response. While it is...
Luteinizing hormone (LH) is secreted in low-amplitude pulses in sexually intact dogs to stimulate synthesis of estrogen and testosterone in females and males, respectively. LH is mainly considered a reproductive hormone, but LH receptors (LHR) have been identified in non-reproductive tissues, including in canine lymphoma and isolated canine T-cell lymphoma...
Analytical techniques are utilized in a wide variety of applications. Traditionally, analytical measurements are achieved by trained personnel in a laboratory setting using expensive scientific instruments, which limits their applicability in resource-limited areas and point-of-care applications. Therefore, the concept of enabling these laboratory-based qualitative and quantitative assays in microfluidic device...
Measuring resistivity as a method to calculate formation factor is becoming a popular way to evaluate transport properties of concrete. Resistivity measurements are dependent on multiple factors including the resistivity of the pore solution, leaching effects, the degree of saturation of the specimen, the age of the specimen (degree of...
Traditional robots have a long history in nuclear-related work because their integration decreases risk to humans in dangerous environments. Soft robotics is one promising new branch of traditional robotics with proposed applications in industry, medicine, and society. Collaborators from the Robotics mLab at Oregon State University (OSU) are currently working...
Nonthermal electrical plasmas can allow energy intensive reactions to occur without the use of high operating temperatures or pressures. This is because the collisions of electrons accelerated through an electric field with molecules is the cause of reactions as opposed to thermal collisions between molecules. In this study, the production...
Augmentative and Alternative Communication (AAC) devices are designed to enable individuals with limited communication abilities to communicate effectively with others. One of the most commonly used AAC devices converts a text input into a vocalized message for the user. These types of AAC devices can be difficult to use and...
Canopy gap formation is a major factor contributing to maintenance of overstory species diversity and stand structure in forests and may be integral to development of understory shrub and herb layers as well. Acknowledgement of gap formation as a fundamental feature of natural forests has led to consideration of gaps...
The geologic processes at work in American Samoa have long been a point of scientific debate. Of its numerous volcanic formations, few breach sea level, leaving an enormous proportion of their mass unavailable to traditional observation. This study aims to describe the deep sea geomorphology of American Samoa through compilation,...
Global energy needs are continuously increasing while fossil fuels remain an uncertain resource. With a growing population and demand for energy, alternative energy sources are being pursued to power the future. Fossil fuels are an unsustainable resource that brings along problems of climate change and atmospheric pollution. Concentrated solar power...
The lead-zirconate-titanate (PZT) solid solution system is currently the workhorse of piezoelectric-based microelectromechanical systems (MEMS) research. Among bulk materials it is known to be one of the strongest piezoelectrics, with extremely high piezoelectric coefficients and electro-mechanical coupling factors. Reproducing these exceptional qualities in thin film form, however, requires precise tuning...
Juniper is a native species to Oregon and confers ecological benefits to wildlife when it is at savannah and transitional densities. Its range and extent have fluctuated with climatic change, but the current range expansion is unprecedented in its extent. The range expansion has been associated with the degradation of...
Light-frame construction practices and materials have changed greatly
over the past 100 years. Contemporary research has focused on modern construction; thus, we know a great deal about the behavior of modern lightframe buildings under lateral forces. However, there are many light-frame buildings that were built prior to the introduction of...
The height of an algebraic number A is a measure of how arithmetically complicated A is. We say A is totally p-adic if the minimal polynomial of A splits completely over the field of p-adic numbers. In this paper, we investigate what can be said about the smallest nonzero height...
The mechanisms governing short- and long-term belowground carbon dynamics need to be understood. As part of a larger project developed to assess the effect of quantity and quality of litter inputs on the rate of soil organic matter (SOM) formation, I examined SOM in the H. J. Andrews Detritus Input...
L-pipecolic acid (L-PA) is the higher homolog of proline. It occurs naturally in
many organisms, including primates, as an intermediate in lysine degradation. The
pathway by which lysine is converted into L-pipecolic acid employs the enzyme Lpipecolate
oxidase (L-PO), and appears to be tissue specific to the central nervous system...
Native populations of forest trees are specifically adapted to the climates they inhabit. The farther trees are moved from their local climates (i.e., as the climatic transfer distance increases), the more growth and survival tend to decrease. The transfer limit is the climatic transfer distance beyond which plantation performance is...
To derive ellipsoid heights on passive marks with cm-level accuracy, many current specifications require the collection and adjustment of long-duration, static Global Navigation Satellite System (GNSS) sessions. To increase efficiency, a survey procedure that includes real-time kinematic vectors from a real-time GNSS network (RTN) was evaluated. Thirty different “hybrid” networks...
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Daniel T. Gillins
To derive ellipsoid heights on passive marks with cm-level accuracy, many
The Comprehensive Nuclear-Test-Ban Treaty (CTBT) prohibits the testing of nuclear weapons on the face of the earth. The detection of atmospheric radioxenon (131mXe, 133m/133Xe, and 135Xe) plays an important role in the identification of sub-surface clandestine nuclear weapon explosions. Since the radioxenon identified above decay via two radiation in coincidence,...
Lateral spread is a pervasive type of liquefaction-induced ground failure that occurs on gentle slopes or near free-faces, such as river channels. Resulting horizontal displacements can reach up to several meters, and can be considerably damaging to foundations, bridges, roadways, pipelines, etc. In the 1990s, Bartlett and Youd (1992a, 1995)...
The First Gulf War that took place in Kuwait in 1991 resulted in one of the worst environmental disasters in the history of mankind. Extreme pollution affected the soil, waters, and the air in Kuwait. In this research I try to look into how the Kuwaiti government reacted to those...
Alcohol is a widely consumed, nonessential, bioactive nutrient with end-organ effects on the skeleton. Moderate levels of alcohol consumption are generally associated with increased bone mineral density (BMD), whereas higher intake levels result in reduced bone formation, bone loss, and increased risk for osteoporotic fracture. Given the negative impact of...
Bi-weekly sampling of zooplankton and environmental parameters was conducted along a cross-shelf transect off the coast of Newport, OR, USA (44.65°N) from 1996 to present. Results have demonstrated the feasibility of using copepod community structure as an early indicator of ecosystem response to seasonal and large scale environmental changes in...
There are over 130 million wood poles supporting electrical transmission and distribution lines in the U.S. The vast majority of these poles are preservative treated to prolong their useful life. In some cases, however, the depth of treatment is relatively shallow, leaving a deep zone of moderately durable, untreated heartwood....
Geotechnical engineers design and analyze the interface between the natural and built environments, often based on uncertain and inherently variable data due to the nature of the building material, soil. Engineers must estimate the subsurface conditions at a site using historical, in-situ, and laboratory testing data. However, only discrete representative...
The logarithmic-spiral (log-spiral) limit equilibrium procedure for slope stability analysis rigorously satisfies both force and moment equilibrium with a failure surface geometry formulated as a function of the soil’s angle of internal friction. Within the framework of limit equilibrium, this procedure has, in the past, been primarily limited to homogeneous...
The pine butterfly (Neophasia menapia C. Felder & R. Felder) (Lepidoptera: Pieridae) is a relatively host-specific defoliator of ponderosa pine (Pinus ponderosa Dougl. ex Laws). From 2008 to 2012, the Malheur National Forest was subject to an outbreak of pine butterfly in ponderosa pine, peaking at ~100,000 ha of forest...
The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
Small unmanned aircraft systems (UAS) carrying consumer-grade nonmetric cameras are increasingly utilized to generate high-resolution 3D geospatial data. Low cost, ease of operation, widespread availability and low altitude maneuvering capabilities of UAS, as well as the rapid development of technology and methods, make UAS-based photogrammetry applicable to many civil engineering...
Intrinsic characteristics of Pacific sardines were determined. The lipid content
in sardines was initially low (6.79%) in the beginning ofthe season, increased to
22.95% in mid-August, and decreased slightly by the end of September. An inverse
correlation (R² = -0.90) was found between lipid and moisture content. Analysis
showed that...