Calcium activated proteases, or calpains, are activated in cardiac muscles under conditions of ischemia/reperfusion and hypoxia. Their activity in skeletal muscle under similar conditions is poorly understood. We tested the hypothesis that hypoxia elevates calpain-mediated proteolysis in isolated glycolytic (extensor digitorum longus, EDL) and oxidative (soleus, SOL) mouse muscles studied...
Inner shelf hypoxia has occurred along the Oregon coast between the latitudes 44ºN
and 45ºN since 2002 with increasing duration and intensity, posing a threat to marine
life. The objective of this research was to determine whether variation in respiration
rate explains spatial and temporal variation in hypoxia. Dissolved oxygen...
In recent years off the United States Oregon coast severe hypoxic events have resulted in areas of mass vertebrate and invertebrate species mortality known as dead zones. Creation of dead zones and alteration of community species composition in response to inner shelf hypoxic conditions have been observed annually from 2002...
Hypoxia is a naturally occurring phenomenon that happens seasonally off the Oregon coast. As a consequence, there has been a great deal of research focused around analyzing the strength and duration of the hypoxic event during the summer season. This paper, however, takes an innovative approach by looking at the...
In order to maintain genetic stability in eukaryotes, tight regulation of the relative sizes of deoxyribonucleoside triphosphate (dNTP) levels inside the cell is essential for optimal fidelity of DNA replication. Ribonucleotide reductase (RNR) is the enzyme responsible for proportional production of DNA precursors. Studies on regulation of this enzyme, the...
The juvenile demersal fish assemblage along the Pacific Northwest coast has received little attention relative to adult life history stages since pioneering work in the 1970s. Increasing severity of hypoxia along the Oregon coast in recent years has prompted investigations into the response of biota in this region. We used...
In the last decade, the California Current Large Marine Ecosystem has experienced a trend of increased severity of upwelling-driven coastal hypoxia. This thesis strove to examine the potential upper trophic level impacts of moderate and severe hypoxia in the CCLME. Initially I conducted a literature review of Pacific harbor seal...
Nearshore hypoxia within the Northern California Current (NCC) system is a seasonal phenomenon caused by coastal upwelling and occurs mainly during late-summer and early fall. The effects of low oxygen levels on fish and invertebrate communities, particularly during early-life history stages, however, are poorly known for this area. I investigated...
The severity of carbonate chemistry changes from ocean acidification is predicted to increase greatly in the coming decades, with serious consequences for marine species- especially those reliant on calcium carbonate for structure and function (Fabry et al. 2008). The Northern California Current Ecosystem off the coast of US West Coast...
Coastal hypoxia, or low oxygen episodes pose a threat to marine resources in the Pacific Northwest. Previous research into nearshore oxygen dynamics have linked coastal upwelling to this seasonally occurring phenomenon, however the manifestation of hypoxic waters over coastal fishing grounds was not well understood. Through a partnership with Dungeness...