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  • Investigation of NAE inhibitor MLN4924 against KHV replication in vitro

    Creator:
    Jensen, Sam I.
    Abstract:
    Koi herpesvirus (KHV) is a pathogen affecting common carp and ornamental koi with high morbidity and mortality. Currently, no effective treatment or vaccine is available against this virus. Cullin RING ubiquitin ligases (CRLs) are a class of host proteins that facilitate infection of DNA viruses, such as herpesviruses. Inhibitors of...
    Resource Type:
    Honors College Thesis
    Full Text:
    Ling Jin Koi herpesvirus (KHV) is a pathogen affecting common carp and ornamental koi with high

  • Investigation of cis-acting RNA element role in bovine viral diarrhea virus replication

    Creator:
    Ly, David
    Abstract:
    Bovine viral diarrhea virus (BVDV) is an enveloped, single-stranded positive-sense RNA virus. The BVDV genome is about 12.5 kb long and consists of a single open reading frame (ORF) flanked by untranslated regions at the 5' and 3' ends (5'-UTR and 3'- UTR, respectively). To investigate the role of cis-sequences...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: Ling Jin Bovine viral diarrhea virus (BVDV) is an enveloped, single-stranded

  • Ultrafiltration Membrane Fouling in Side-stream Aerobic Granular Sludge Membrane Bioreactor

    Creator:
    Yang, Zhengjian
    Abstract:
    The integration of low-pressure membrane filtration and aerobic granular sludge (AGS) reactor leads to a novel environmental biotechnological process with strong potential to overcome membrane fouling and demonstrate excellent wastewater treatment performance. However, membrane fouling mechanisms in the AGS based membrane bioreactor (MBR) are lack of systematic elaboration. In the...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: ______________________________________________________ Xue Jin The

  • The conserved biology of herpesvirus latency : a study in cyprinid herpesvirus 3

    Creator:
    Reed, Aimee N.
    Abstract:
    Cyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the Alloherpesviridae and is a deadly pathogen for koi and common carp, Cyprinus carpio. It causes severe gill necrosis and nephritis, dermal ulceration and hemorrhage, and mass mortality of up to 100% of affected fish. Fish...
    Resource Type:
    Dissertation
    Full Text:
    Jin Cyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the

  • The Effect of Dissolved O₂ Level on KHV Reactivation from Latency and Pathologic analysis during KHV Reactivation

    Creator:
    Chen, Sammi
    Abstract:
    Koi herpesvirus (KHV) is a new emerging viral pathogen of koi and common carps. It has been demonstrated that KHV becomes latent in the white blood cells in the recovered koi. The latent KHV can be reactivated under stressful conditions, such as heat and injury, and the reactivated viruses can...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Ling Jin Koi herpesvirus (KHV) is a new emerging viral pathogen of koi and common

  • Genomic characterization of a novel leporid Herpes simplex virus

    Creator:
    Babra, Bobby A.
    Abstract:
    The viral family Herpesviridae consists of large double stranded DNA viruses including eight species that infect humans with varying pathology from benign rashes to cancerous cell transformation. From three subfamilies, alpha-, beta- and gammaherpes, the alphaherpes contains the genera iltovirus, mardivirus, varicellovirus and simplex, two of which, the human simplex...
    Resource Type:
    Dissertation
    Full Text:
    : ____________________________________________________________ Ling Jin The viral family Herpesviridae consists of large double stranded DNA viruses

  • Investigation of KHV DNA Methylation during Productive and Latent Infection

    Creator:
    Lin, Lisa
    Abstract:
    Koi herpesvirus (KHV), is a highly pathogenic virus causing high mortality in common carp and koi, especially in fry. One of the unique features of herpesvirus infections is their ability to become latent following initial infection. During latent infection, only viral genome persists in the host and remains dormant in...
    Resource Type:
    Honors College Thesis
    Full Text:
    Latent Infection. Abstract approved:_____________________________________________________ Ling Jin

  • Interaction of the Respiratory Syncytial Virus Matrix Protein and the Cellular Adaptor Protein Complex 3µ Subunit

    Creator:
    Ward, Casey J.
    Abstract:
    Respiratory Syncytial Virus (RSV) is a leading cause of bronchopneumonia in infants and elderly. Knowledge of viral and host protein interactions is important for better understanding of the viral pathogenesis and may lead to development of novel therapeutic drugs. Here, we show that RSV Matrix (M) protein interacts with cellular...
    Resource Type:
    Honors College Thesis
    Full Text:
    Anne-Marie Girgard. I would also like to thank my committee, Dr. Manoj Pastey, Dr. Ling Jin, and

  • An experimental study on tensile properties of cellulose nanocrystal reinforced epoxy nanocomposite material

    Creator:
    Zeng, Jin
    Abstract:
    Epoxy resin is a thermosetting resin that is commonly used as composite matrix. Epoxy composite materials are well utilized in industries, such as aerospace, due to their good mechanical properties. Nano-scale filler reinforced polymer composite materials have been intensively researched in recent decades. Cellulose nanocrystals (CNXLs) are a type of...
    Resource Type:
    Masters Thesis
    Full Text:
    Microsoft Word - Jin Zeng - Thesis.doc AN

  • Molecular origins of surfactant-mediated stabilization of protein

    Creator:
    Lee, Hyo Jin
    Abstract:
    Nonionic surfactants are commonly used to stabilize proteins during upstream and downstream processing and drug formulation. Surfactants stabilize the proteins through two major mechanisms: (i) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (ii) their association with protein into "complexes" that prevent proteins from interacting...
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE DISSERTATION OF Hyo Jin Lee for the degree of Doctor of Philosophy in Chemical