Index Catalog // ScholarsArchive@OSU

Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

Creator:: Cavalier, Michael C., Yim, Young-Sun, Asamizu, Shumpei, Neau, David, Almabruk, Khaled H., Mahmud, Taifo, and Lee, Yong-Hwan
Abstract:: The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic validamycin A. To study the molecular basis of its mechanism, the three-dimensional structures of...
Resource Type:: Article
Full Text:: -Sun Yim1., Shumpei Asamizu2, David Neau3, Khaled H. Almabruk2, Taifo Mahmud2, Yong-Hwan Lee1* 1

An update to the Surface Ocean CO₂ Atlas (SOCAT version 2)

Creator:: Bakker, D. C. E., Pfeil, B., Smith, K., Hankin, S., Olsen, A., Alin, S. R., Cosca, C., Harasawa, S., Kozyr, A., Nojiri, Y., O'Brien, K. M., Schuster, U., Telszewski, M., Tilbrook, B., Wada, C., Akl, J., Barbero, L., Bates, N. R., Boutin, J., Bozec, Y., Cai, W.-J., Castle, R. D., Chavez, F. P., Chen, L., Chierici, M., Currie, K., de Baar, H. J. W., Evans, W., Feely, R. A., Fransson, A., Gao, Z., Hales, B., Hardman-Mountford, N. J., Hoppema, M., Huang, W.-J., Hunt, C. W., Huss, B., Ichikawa, T., Johannessen, T., Jones, E. M., Jones, S. D., Jutterström, S., Kitidis, V., Körtzinger, A., Landschützer, P., Lauvset, S. K., Lefèvre, N., Manke, A. B., Mathis, J. T., Merlivat, L., Metzl, N., Murata, A., Newberger, T., Omar, A. M., Ono, T., Park, G.-H., Paterson, K., Pierrot, D., Ríos, A. F., Sabine, C. L., Saito, S., Salisbury, J., Sarma, V. V. S. S., Schlitzer, R., Sieger, R., Skjelvan, I., Steinhoff, T., Sullivan, K. F., Sun, H., Sutton, A. J., Suzuki, T., Sweeney, C., Takahashi, T., Tjiputra, J., Tsurushima, N., van Heuven, S. M. A. C., Vandemark, D., Vlahos, P., Wallace, D. W. R., Wanninkhof, R., and Watson, A. J.
Abstract:: The Surface Ocean CO2 Atlas (SOCAT), an activity of the international marine carbon research community, provides access to synthesis and gridded fCO2 (fugacity of carbon dioxide) products for the surface oceans. Version 2 of SOCAT is an update of the previous release (version 1) with more data (increased from 6.3...
Resource Type:: Article

Evaluating the agreement between measurements and models of net ecosystem exchange at different times and timescales using wavelet coherence: an example using data from the North American Carbon Program Site-Level Interim Synthesis

Creator:: Stoy, P. C., Dietze, M. C., Richardson, A. D., Vargas, R., Barr, A. G., Anderson, R. S., Arain, M. A., Baker, Ian T., Black, T. Andrew, Chen, J. M., Cook, R. B., Gough, C. M., Grant, R. F., Hollinger, D. Y., Izaurralde, R. C., Kucharik, C. J., Lafleur, P., Law, B. E., Liu, S., Lokupitiya, E., Luo, Y., Munger, J. W., Peng, C., Poulter, B., Price, D. T., Ricciuto, D. M., Riley, W. J., Sahoo, A. K., Schaefer, K., Schwalm, C. R., Tian, H., Verbeeck, H., and Weng, E.
Abstract:: Earth system processes exhibit complex patterns across time, as do the models that seek to replicate these processes. Model output may or may not be significantly related to observations at different times and on different frequencies. Conventional model diagnostics provide an aggregate view of model–data agreement, but usually do not...
Resource Type:: Article

Performance of Linear and Nonlinear Two-Leaf Light Use Efficiency Models at Different Temporal Scales

Creator:: Wu, Xiaocui, Ju, Weimin, Zhou, Yanlian, He, Mingzhu, Law, Beverly E., Black, T. Andrew, Margolis, Hank A., Cescatti, Alessandro, Gu, Lianhong, Montagnani, Leonardo, Noormets, Asko, Griffis, Timothy J., Pilegaard, Kim, Varlagin, Andrej, Valentini, Riccardo, Blanken, Peter D., Wang, Shaoqiang, Wang, Huimin, Han, Shijie, Yan, Junhua, Li, Yingnian, Zhou, Bingbing, and Liu, Yibo
Abstract:: The reliable simulation of gross primary productivity (GPP) at various spatial and temporal scales is of significance to quantifying the net exchange of carbon between terrestrial ecosystems and the atmosphere. This study aimed to verify the ability of a nonlinear two-leaf model (TL-LUEn), a linear two-leaf model (TL-LUE), and a...
Resource Type:: Article
Full Text:: multiple scattering of total PAR within the canopy [24]; φ is the mean leaf-sun angle and set as 60º[24

Astragaloside IV Inhibits NF-κB Activation and Inflammatory Gene Expression in LPS-Treated Mice

Creator:: Zhang, Wei-Jian and Frei, Balz
Abstract:: In this study we investigated the role of astragaloside IV (AS-IV), one of the major active constituents purified from the Chinese medicinal herb Astragalus membranaceus, in LPS-induced acute inflammatory responses in mice in vivo and examined possible underlying mechanisms. Mice were assigned to four groups: vehicle-treated control animals; AS-IV-treated animals...
Resource Type:: Article
Full Text:: , vol. 5, no. 9, Article ID e12561, 2010. [13] X. J. Chen, Z.-P. Bian, S. Lu et al., “Cardiac

Evaluation and improvement of the Community Land Model (CLM4) in Oregon forests

Creator:: Hudiburg, T. W., Law, B. E., and Thornton, P. E.
Abstract:: Ecosystem process models are important tools for determining the interactive effects of global change and disturbance on forest carbon dynamics. Here we evaluated and improved terrestrial carbon cycling simulated by the Community Land Model (CLM4), the land model portion of the Community Earth System Model (CESM1.0.4). Our analysis was conducted...
Resource Type:: Article

Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits

Creator:: Megraw, Molly, Mukherjee, Sayan, and Ohler, Uwe
Abstract:: WaRSwap is a randomization algorithm that for the first time provides a practical network motif discovery method for large multi-layer networks, for example those that include transcription factors, microRNAs, and non-regulatory protein coding genes. The algorithm is applicable to systems with tens of thousands of genes, while accounting for critical...
Resource Type:: Article
Full Text:: run on Sun Grid Engine; we have made the script sets available for others to use and adapt under the

Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish

Creator:: Rodriguez-Mari, Adriana, Wilson, Catherine, Titus, Tom A., Canestro, Cristian, BreMiller, Ruth A., Yan, Yi-Lin, Nanda, Indrajit, Johnston, Adam, Kanki, John P., Gray, Erin M., He, Xinjun, Spitsbergen, Jan, Schindler, Detlev, and Postlethwait, John H.
Abstract:: Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a novel brca2 function in oogenesis. Experiments showed that...
Resource Type:: Article

Simulated Evolution of Protein-Protein Interaction Networks with Realistic Topology

Creator:: Peterson, G. Jack, Pressé, Steve, Peterson, Kristin S., and Dill, Ken A.
Abstract:: We model the evolution of eukaryotic protein-protein interaction (PPI) networks. In our model, PPI networks evolve by two known biological mechanisms: (1) Gene duplication, which is followed by rapid diversification of duplicate interactions. (2) Neofunctionalization, in which a mutation leads to a new interaction with some other protein. Since many...
Resource Type:: Article
Full Text:: . Ting CT, Tsaur SC, Sun S, Browne W, Chen YC, et al. (2004) Gene duplication and speciation in

Estimating heterotrophic respiration at large scales: challenges, approaches, and next steps

Creator:: Bond-Lamberty, Ben, Epron, Daniel, Harden, Jennifer, Harmon, Mark E., Hoffman, Forrest, Kumar, Jitendra, David McGuire, Anthony, and Vargas, Rodrigo
Abstract:: Heterotrophic respiration (HR), the aerobic and anaerobic processes mineralizing organic matter, is a key carbon flux but one impossible to measure at scales significantly larger than small experimental plots. This impedes our ability to understand carbon and nutrient cycles, benchmark models, or reliably upscale point measurements. Given that a new...
Resource Type:: Article
Full Text:: ., D. Epron, J.-C. Domec, S. G. McNulty, T. Fox, G. Sun, and J. S. King. 2015. Effects of forest

ScholarsArchive@OSU

Mechanistic Insights into Validoxylamine A 7’-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

An update to the Surface Ocean CO₂ Atlas (SOCAT version 2)

Evaluating the agreement between measurements and models of net ecosystem exchange at different times and timescales using wavelet coherence: an example using data from the North American Carbon Program Site-Level Interim Synthesis

Performance of Linear and Nonlinear Two-Leaf Light Use Efficiency Models at Different Temporal Scales

Astragaloside IV Inhibits NF-κB Activation and Inflammatory Gene Expression in LPS-Treated Mice

Evaluation and improvement of the Community Land Model (CLM4) in Oregon forests

Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits

Roles of brca2 (fancd1) in Oocyte Nuclear Architecture, Gametogenesis, Gonad Tumors, and Genome Stability in Zebrafish

Simulated Evolution of Protein-Protein Interaction Networks with Realistic Topology

Estimating heterotrophic respiration at large scales: challenges, approaches, and next steps

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