Index Catalog // ScholarsArchive@OSU

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Creator:: Shorey, Lyndsey E., Hagman, Amanda M., Williams, David E., Ho, Emily, Dashwood, Roderick H., and Benninghoff, Abby D.
Abstract:: Certain bioactive food components, including indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from cruciferous vegetables, have been shown to target cellular pathways regulating carcinogenesis. Previously, our laboratory showed that dietary I3C is an effective transplacental chemopreventive agent in a dibenzo[def,p]chrysene (DBC)-dependent model of murine T-cell lymphoblastic lymphoma. The primary objective of the...
Resource Type:: Article
Full Text:: Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells Lyndsey E. Shorey1,2, Amanda M. Hagman3, David

Antioxidants to enhance fertility: Role of eNOS and Potential Benefits

Creator:: Visioli, Francesco and Hagen, Tory M.
Abstract:: The use of antioxidants is now often used as a pharmacological adjunct to limit infertility. Indeed, the lay public rightly perceives oxidative stress and, thus, antioxidant treatment as important modulators of infertility. While the direct effects of antioxidant treatment on the quality of semen and oocytes are still under investigation,...
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Full Text:: to enhance fertility: Role of eNOS and Potential Benefits Francesco Visioli, Tory M. Hagen

Linden (Tilia cordata) associated bumble bee mortality : metabolomic analysis of nectar and bee muscle

Creator:: Lande, Claire, Rao, Sujaya, Morre, Jeffrey T., Galindo, Gracie, Kirby, Julie, Reardon, Patrick N., Bobe, Gerd, and Stevens, Jan Frederik
Abstract:: Linden (Tilia spp.), a profusely flowering temperate tree that provides bees with vital pollen and nectar, has been associated with bumble bee (Bombus spp.) mortality in Europe and North America. Bee deaths have been attributed, with inadequate evidence, to toxicity from mannose in nectar or starvation due to low nectar...
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Full Text:: mortality: Metabolomic analysis of nectar and bee muscle Claire Lande1☯, Sujaya RaoID 1☯¤*, Jeffrey T

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

Creator:: Miller, Galen W., Ulatowski, Lynn, Labut, Edwin M., Lebold, Katie M., Manor, Danny, Atkinson, Jeffrey, Barton, Carrie L., Tanguay, Robert L., and Traber, Maret G.
Abstract:: The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring...
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Full Text:: Metab 89: 1452–1458. 4. Jishage K, Arita M, Igarashi K, Iwata T, Watanabe M, et al. (2001) Alpha

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

Creator:: Beaver, Laura M., Klichko, Vladimir I., Chow, Eileen S., Kotwica-Rolinska, Joanna, Williamson, Marisa, Orr, William C., Radyuk, Svetlana N., and Giebultowicz, Jadwiga M.
Abstract:: Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a...
Resource Type:: Article
Full Text:: and Biosynthesis in Drosophila melanogaster Laura M. Beaver1¤a, Vladimir I. Klichko2, Eileen S. Chow1

Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Creator:: Shorey, Lyndsey, Castro, David J., Baird, William, Siddens, Beth, Lohr, Christiane, Matzke, Melissa, Waters, Katrina M., Corley, Richard A., and Williams, David E.
Abstract:: Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver....
Resource Type:: Article
Full Text:: . Perera, D. Tang, Y.-H. Tu, L.A. Cruz, M. Borjas, T. Bernert, R.M. Whyatt, Biomarkers in maternal and

Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α

Creator:: Sheng, Zhi-Guo and Zhu, Ben-Zhan
Abstract:: BACKGROUND: Bisphenol A (BPA) is one of the most prevalent chemicals in daily-use materials; therefore, human exposure to BPA is ubiquitous. The estrogenicity of BPA is generally mediated by nuclear estrogen receptors (ERs). However, low concentrations of BPA stimulate seminoma cell proliferation by an uncertain mechanism that does not involve...
Resource Type:: Article
Full Text:: study, we examined whether low concentrations of BPA (10–12 to 10–7 M), which are environmentally

Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism

Creator:: Yin, Ruichuan, Zhang, Dapeng, Song, Yuling, Zhu, Ben-Zhan, and Wang, Hailin
Abstract:: Polyhalogenated quinones are a class of carcinogenic intermediates. We found recently that the highly reactive and biologically/environmentally important center [dot]OH can be produced by polyhalogenated quinones and H₂O₂ independent of transition metal ions. However, it is not clear whether this unusual metal-independent center dot OH producing system can induce potent...
Resource Type:: Article
Full Text:: . Sci. USA 104, 17575–17578 (2007). 19. Bolton, J. L., Trush, M. A., Penning, T. M., Dryhurst, G

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Creator:: Lytle, Kelli A. and Jump, Donald B.
Abstract:: Background: Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH,...
Resource Type:: Article
Full Text:: were included in the analysis. Student’s t-test was used when only two groups were being compared and

Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats

Creator:: Legette, LeeCole L., Luna, Arlyn Y. Moreno, Reed, Ralph L., Miranda, Cristobal L., Bobe, Gerd, Proteau, Rosita R., and Stevens, Jan F.
Abstract:: Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses...
Resource Type:: Article
Full Text:: were separated on a 4  250 mm Luna 5 μm C18 reversed phase column (Phenomenex, Torrance, CA), eluted

ScholarsArchive@OSU

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Antioxidants to enhance fertility: Role of eNOS and Potential Benefits

Linden (Tilia cordata) associated bumble bee mortality : metabolomic analysis of nectar and bee muscle

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α

Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats

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