Index Catalog // ScholarsArchive@OSU

Antioxidants to enhance fertility: Role of eNOS and Potential Benefits

Creator:: Visioli, Francesco and Hagen, Tory M.
Abstract:: The use of antioxidants is now often used as a pharmacological adjunct to limit infertility. Indeed, the lay public rightly perceives oxidative stress and, thus, antioxidant treatment as important modulators of infertility. While the direct effects of antioxidant treatment on the quality of semen and oocytes are still under investigation,...
Resource Type:: Article
Full Text:: A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Resource Type:: Article

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Creator:: Lytle, Kelli A. and Jump, Donald B.
Abstract:: Background: Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH,...
Resource Type:: Article
Full Text:: Reversible? Lytle, K. A., & Jump, D. B. (2016). Is Western Diet-Induced Nonalcoholic Steatohepatitis in

Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Creator:: Shorey, Lyndsey, Castro, David J., Baird, William, Siddens, Beth, Lohr, Christiane, Matzke, Melissa, Waters, Katrina M., Corley, Richard A., and Williams, David E.
Abstract:: Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver....
Resource Type:: Article
Full Text:: A and C, respectively, whereas the maternal and fetal plasma levels are shown in panel B. Time

Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α

Creator:: Sheng, Zhi-Guo and Zhu, Ben-Zhan
Abstract:: BACKGROUND: Bisphenol A (BPA) is one of the most prevalent chemicals in daily-use materials; therefore, human exposure to BPA is ubiquitous. The estrogenicity of BPA is generally mediated by nuclear estrogen receptors (ERs). However, low concentrations of BPA stimulate seminoma cell proliferation by an uncertain mechanism that does not involve...
Resource Type:: Article
Full Text:: PKG and EGFR/ERK/ c-fos pathways through a cross-talk between GPR30 and ER-α, which in turn stimulates

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

Creator:: Beaver, Laura M., Klichko, Vladimir I., Chow, Eileen S., Kotwica-Rolinska, Joanna, Williamson, Marisa, Orr, William C., Radyuk, Svetlana N., and Giebultowicz, Jadwiga M.
Abstract:: Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a...
Resource Type:: Article
Full Text:: profile (C). Data for (A–C) were analyzed by a 1-way ANOVA and Bonferroni’s post-tests, and an asterisk

Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism

Creator:: Yin, Ruichuan, Zhang, Dapeng, Song, Yuling, Zhu, Ben-Zhan, and Wang, Hailin
Abstract:: Polyhalogenated quinones are a class of carcinogenic intermediates. We found recently that the highly reactive and biologically/environmentally important center [dot]OH can be produced by polyhalogenated quinones and H₂O₂ independent of transition metal ions. However, it is not clear whether this unusual metal-independent center dot OH producing system can induce potent...
Resource Type:: Article
Full Text:: traces a-c. Trace (d) was obtained from the analysis of the mixture of dG (0.2 mM) and 8-oxodG (10 nM

Linden (Tilia cordata) associated bumble bee mortality : metabolomic analysis of nectar and bee muscle

Creator:: Lande, Claire, Rao, Sujaya, Morre, Jeffrey T., Galindo, Gracie, Kirby, Julie, Reardon, Patrick N., Bobe, Gerd, and Stevens, Jan Frederik
Abstract:: Linden (Tilia spp.), a profusely flowering temperate tree that provides bees with vital pollen and nectar, has been associated with bumble bee (Bombus spp.) mortality in Europe and North America. Bee deaths have been attributed, with inadequate evidence, to toxicity from mannose in nectar or starvation due to low nectar...
Resource Type:: Article
Full Text:: to this work. * sujaya@umn.edu Abstract Linden (Tilia spp.), a profusely flowering temperate tree

Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats

Creator:: Legette, LeeCole L., Luna, Arlyn Y. Moreno, Reed, Ralph L., Miranda, Cristobal L., Bobe, Gerd, Proteau, Rosita R., and Stevens, Jan F.
Abstract:: Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses...
Resource Type:: Article
Full Text:: 0 100 200 300 400 500 600 * Treatment P la s m a G lu c o s e ( m g /d L

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

Creator:: Miller, Galen W., Ulatowski, Lynn, Labut, Edwin M., Lebold, Katie M., Manor, Danny, Atkinson, Jeffrey, Barton, Carrie L., Tanguay, Robert L., and Traber, Maret G.
Abstract:: The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring...
Resource Type:: Article
Full Text:: fairly even distribution, however, in C a dorsal view of the rostral region with the yolk removed shows

ScholarsArchive@OSU

Antioxidants to enhance fertility: Role of eNOS and Potential Benefits

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism

Linden (Tilia cordata) associated bumble bee mortality : metabolomic analysis of nectar and bee muscle

Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

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