Index Catalog // ScholarsArchive@OSU

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

Creator:: Beaver, Laura M., Klichko, Vladimir I., Chow, Eileen S., Kotwica-Rolinska, Joanna, Williamson, Marisa, Orr, William C., Radyuk, Svetlana N., and Giebultowicz, Jadwiga M.
Abstract:: Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a...
Resource Type:: Article
Full Text:: medium, provided the original author and source are credited. Funding: This research was supported by

Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats

Creator:: Legette, LeeCole L., Luna, Arlyn Y. Moreno, Reed, Ralph L., Miranda, Cristobal L., Bobe, Gerd, Proteau, Rosita R., and Stevens, Jan F.
Abstract:: Obesity contributes to increased risk for several chronic diseases including cardiovascular disease and type 2 diabetes. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus), was tested for efficacy on biomarkers of metabolic syndrome in 4 week old Zucker fa/fa rats, a rodent model of obesity. Rats received daily oral doses...
Resource Type:: Article
Full Text:: observed in this study correspond to predicted values from earlier research. (Legette et al. 2012). As

Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism

Creator:: Yin, Ruichuan, Zhang, Dapeng, Song, Yuling, Zhu, Ben-Zhan, and Wang, Hailin
Abstract:: Polyhalogenated quinones are a class of carcinogenic intermediates. We found recently that the highly reactive and biologically/environmentally important center [dot]OH can be produced by polyhalogenated quinones and H₂O₂ independent of transition metal ions. However, it is not clear whether this unusual metal-independent center dot OH producing system can induce potent...
Resource Type:: Article
Full Text:: Ecotoxicology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085

Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α

Creator:: Sheng, Zhi-Guo and Zhu, Ben-Zhan
Abstract:: BACKGROUND: Bisphenol A (BPA) is one of the most prevalent chemicals in daily-use materials; therefore, human exposure to BPA is ubiquitous. The estrogenicity of BPA is generally mediated by nuclear estrogen receptors (ERs). However, low concentrations of BPA stimulate seminoma cell proliferation by an uncertain mechanism that does not involve...
Resource Type:: Article
Full Text:: | December 2011 1775 Research Bisphenol A (BPA) has been widely used in the manufacture of various

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

Creator:: Miller, Galen W., Ulatowski, Lynn, Labut, Edwin M., Lebold, Katie M., Manor, Danny, Atkinson, Jeffrey, Barton, Carrie L., Tanguay, Robert L., and Traber, Maret G.
Abstract:: The hepatic α-tocopherol transfer protein (TTP) is required for optimal α-tocopherol bioavailability in humans; mutations in the human TTPA gene result in the heritable disorder ataxia with vitamin E deficiency (AVED, OMIM #277460). TTP is also expressed in mammalian uterine and placental cells and in the human embryonic yolk-sac, underscoring...
Resource Type:: Article
Full Text:: , provided the original author and source are credited. Funding: This publication was made possible, in part

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Creator:: Shorey, Lyndsey E., Hagman, Amanda M., Williams, David E., Ho, Emily, Dashwood, Roderick H., and Benninghoff, Abby D.
Abstract:: Certain bioactive food components, including indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM) from cruciferous vegetables, have been shown to target cellular pathways regulating carcinogenesis. Previously, our laboratory showed that dietary I3C is an effective transplacental chemopreventive agent in a dibenzo[def,p]chrysene (DBC)-dependent model of murine T-cell lymphoblastic lymphoma. The primary objective of the...
Resource Type:: Article
Full Text:: States of America, 6 The Utah Science Technology and Research Applied Nutrition Research, Utah State

Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Creator:: Shorey, Lyndsey, Castro, David J., Baird, William, Siddens, Beth, Lohr, Christiane, Matzke, Melissa, Waters, Katrina M., Corley, Richard A., and Williams, David E.
Abstract:: Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver....
Resource Type:: Article
Full Text:: Research Center,6The College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, and

Antioxidants to enhance fertility: Role of eNOS and Potential Benefits

Creator:: Visioli, Francesco and Hagen, Tory M.
Abstract:: The use of antioxidants is now often used as a pharmacological adjunct to limit infertility. Indeed, the lay public rightly perceives oxidative stress and, thus, antioxidant treatment as important modulators of infertility. While the direct effects of antioxidant treatment on the quality of semen and oocytes are still under investigation,...
Resource Type:: Article
Full Text:: of basic research supporting the epidemiological evidence of a lower CHD incidence in the

Delivering the cell-impermeable DNA 'light-switching' Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method

Creator:: Zhu, Ben-Zhan, Chao, Xi-Juan, Huang, Chun-Hua, and Li, Yan
Abstract:: The dipyridophenazine (dppz) based ruthenium polypyridyl complexes are known as molecular ‘light-switches’ for DNA. This property is poised to serve in diagnostic and therapeutic applications, but the poor cellular uptake restricts their use in live cells. Herein, we show that the cellular uptake, and more interestingly and surprisingly, the nuclear...
Resource Type:: Article

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(-/-) mice by targeting the TGFβ-Smad3 pathway

Creator:: Lytle, Kelli A., Depner, Christopher M., Wong, Carmen P., and Jump, Donald B.
Abstract:: DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...
Resource Type:: Article

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Creator:: Lytle, Kelli A. and Jump, Donald B.
Abstract:: Background: Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH,...
Resource Type:: Article
Full Text:: /journal.pone.0146942 Public Library of Science Version of Record http://cdss.library.oregonstate.edu/sa

Effects of Sulforaphane and 3,3'-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

Creator:: Wong, Carmen P., Hsu, Anna, Buchanan, Alex, Palomera-Sanchez, Zoraya, Beaver, Laura M., Houseman, E. Andres, Williams, David E., Dashwood, Roderick H., and Ho, Emily
Abstract:: Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3′-diindolylmethane (DIM) are promising chemopreventive agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor suppressor genes silenced...
Resource Type:: Article

ScholarsArchive@OSU

Circadian Regulation of Glutathione Levels and Biosynthesis in Drosophila melanogaster

Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats

Potent DNA damage by polyhalogenated quinones and H₂O₂ via a metal-independent and Intercalation-enhanced oxidation mechanism

Low Concentrations of Bisphenol A Induce Mouse Spermatogonial Cell Proliferation by G Protein–Coupled Receptor 30 and Estrogen Receptor-α

The α-Tocopherol Transfer Protein Is Essential for Vertebrate Embryogenesis

3,3'-Diindolylmethane Induces G₁ Arrest and Apoptosis in Human Acute T-Cell Lymphoblastic Leukemia Cells

Transplacental Carcinogenesis with Dibenzo[def,p]chrysene (DBC): Timing of Maternal Exposures Determines Target Tissue Response in Offspring

Antioxidants to enhance fertility: Role of eNOS and Potential Benefits

Delivering the cell-impermeable DNA 'light-switching' Ru(II) complexes preferentially into live-cell nucleus via an unprecedented ion-pairing method

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr(-/-) mice by targeting the TGFβ-Smad3 pathway

Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr(-/-) Mice Reversible?

Effects of Sulforaphane and 3,3'-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

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