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Creator:: Shorey, Lyndsey, Castro, David J., Baird, William, Siddens, Beth, Lohr, Christiane, Matzke, Melissa, Waters, Katrina M., Corley, Richard A., and Williams, David E.
Abstract:: Dibenzo[def,p]chrysene (DBC) is a transplacental carcinogen in mice (15 mg/kg; gestation day (GD) 17). To mimic residual exposure throughout pregnancy, dams received 4 smaller doses of DBC (3.75 mg/kg) on GD 5, 9, 13 and 17. This regimen alleviated the previously established carcinogenic responses in the thymus, lung, and liver....
Resource Type:: Article
Full Text:: . Castro1,3, William Baird1,4,5, Beth Siddens1,4,5, Christiane Löhr4,5,6, Melissa Matzke7, Katrina M

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Resource Type:: Article

Creator:: Beaver, Laura M., Klichko, Vladimir I., Chow, Eileen S., Kotwica-Rolinska, Joanna, Williamson, Marisa, Orr, William C., Radyuk, Svetlana N., and Giebultowicz, Jadwiga M.
Abstract:: Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a...
Resource Type:: Article
Full Text:: , Joanna Kotwica-Rolinska1,3, Marisa Williamson1¤b, William C. Orr2, Svetlana N. Radyuk2*, Jadwiga M

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