Index Catalog // ScholarsArchive@OSU

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis
Full Text:: .2013.02.015 19. Shi C, Zhang X, Chen Z, et al. (2004) Integrin engagement regulates monocyte

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

Creator:: Choudhury, Mudra
Abstract:: While monocytes are vital for host defense against pathogens, in cases of non-resolving inflammation, monocytes and their differentiated progeny can secrete tissue-damaging factors, present auto-antigens, and promote the inflammatory response. In this study, a systems biology approach was used to map human monocyte gene regulatory regions by integrating expression quantitative...
Resource Type:: Honors College Thesis
Full Text:: .2013.02.015 19. Shi C, Zhang X, Chen Z, et al. (2004) Integrin engagement regulates monocyte

Fungal endophytes as source to combat bacterial infections

Creator:: Green, Jaimie R
Abstract:: Endophytes, foliage inhabiting fungi, are an unexplored source of fungal biodiversity and a potential resource for the production of bioactive natural products. In this research, leaf tissues from the species Arbutus menziesii, Rhododendron macrophyllum and the genus, Ilex and Salix were collected for the isolation of endophytic fungi. Fungal extracts...
Resource Type:: Presentation and Undergraduate Thesis
Full Text:: isolated from Cladonia macilenta (Leu Heng et al. 2012). Biruloquinone has a matching molecular weight

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Creator:: Mans, Michael-Andres D.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Resource Type:: Undergraduate Thesis
Full Text:: /articles/PMC5759260/. Chen S, Li P, Yang R, Cheng R, Zhang F, Wang Y, Chen X, Sun Q, Zang W, Du Y, et al

Targeting chemotherapeutic resistance in breast cancer

Creator:: Avery, Jonathan
Abstract:: The Bcl-2 family of proteins regulate cell survival and are targets for cancer therapy. This protein family has also been implicated in chemotherapeutic resistance, the cause of approximately 90% of treatment failure in advanced cancer. We analyzed the expression and the role of the Bcl-2 proteins in chemotherapy resistant breast...
Resource Type:: Undergraduate Thesis
Full Text:: initiated only through the mitochondrial apoptotic pathway (Chen et al. 2007, 1). ABT-737 has been shown

Enhancing Protocols to Improve Consistency Across Nanotoxicology Studies

Creator:: Luker, Sabrina R.
Abstract:: In current nanotoxicology research, there is a lack of standardization in reporting of zebrafish exposure media and sonication practices. This lack of standardization in use and reporting methods has made reproducing nanoparticle (NP) toxicity results between labs a common issue. It is important to have a standardized way of reporting...
Resource Type:: Undergraduate Thesis
Full Text:: , 40 kHz 450 1000 Yes MQ (Zhu, Chang, & Chen, 2010) Al2O3 ultrasonicator (Sonics, USA

Gene expression analysis in feline injection-site sarcoma : differential expression of the ΔNp63 and TAp63 isoforms

Creator:: Dien, Thalia
Abstract:: Background Feline injection-site sarcoma (FISS) is a rare and aggressive tumor associated with vaccines, drug injections, and skin trauma in cats. The understanding of FISS remains limited, posing challenges in its diagnosis, treatment, and prevention. In this study, we analyzed the differential expression of miRNAs and their target genes in...
Resource Type:: Undergraduate Thesis

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Creator:: Valdez, Teresa
Abstract:: There is increased emphasis on understanding cumulative risk from the combined effects of chemical and non-chemical stressors as it relates to public health. Recent animal studies have identified pulmonary inflammation as a possible modifier and risk factor for chemical toxicity in the lung after exposure to inhaled pollutants; however, little...
Resource Type:: Honors College Thesis
Full Text:: ., Hyde, D. M., Hotchkiss, J. A., Zhang, Y., Novikov, A., Dolganov, G., & Fahy, J. V. (2001). Mild and

Biogas inhibition of fats, oils, and greases with varying ammonia levels

Creator:: Aranda, Ana A.
Abstract:: Biogas can be used to generate energy from a wide variety of sources. Wastewater treatment sludge is an effective source of waste to be used for generation of biogas to make energy which can be used to heat homes and run businesses. This would help decrease the use of fossil...
Resource Type:: Undergraduate Thesis
Full Text:: ., Chen, C., Liu, G., & Zhang, R. (2016). Effects of Ammonia on Anaerobic Digestion of Food Waste

Characterization of Selective Knockout of Thioredoxin Reductase-1 (TR1) in Mouse Melanocytes In Vivo

Creator:: Wyant, Mark B.
Abstract:: Vitiligo is a disease characterized by depigmented patches of skin. The disease is known to involve the loss of melanocytes in the basal layer of the skin in affected areas, but the underlying mechanisms are unknown. Recent evidence suggests oxidative stress and disruptions to antioxidant pathways contribute to an autoimmune...
Resource Type:: Undergraduate Thesis
Full Text:: expected to see TR1 in the melanocyte cytoplasm (Zhang et al., 2016). Therefore, using IHC co-staining

ScholarsArchive@OSU

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks.

The Development and Application of a Systems Biology Approach to Mapping Monocyte Gene Regulatory Networks

Fungal endophytes as source to combat bacterial infections

Functional consequences of microRNA regulation by polycyclic aromatic hydrocarbons in 3D human bronchial epithelial cells

Targeting chemotherapeutic resistance in breast cancer

Enhancing Protocols to Improve Consistency Across Nanotoxicology Studies

Gene expression analysis in feline injection-site sarcoma : differential expression of the ΔNp63 and TAp63 isoforms

Understanding polycyclic aromatic hydrocarbon (PAH) toxicity and inflammation in human bronchial epithelial cells

Biogas inhibition of fats, oils, and greases with varying ammonia levels

Characterization of Selective Knockout of Thioredoxin Reductase-1 (TR1) in Mouse Melanocytes In Vivo

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