There exists a growing need to establish a better in vitro model for evaluating PAH toxicity and carcinogenicity and to improve assessments of risk to human health, especially to the complex mixtures that exist in the environment. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants due to the incomplete combustion...
There exists a growing need to establish a better in vitro model for evaluating PAH toxicity and carcinogenicity and to improve assessments of risk to human health, especially to the complex mixtures that exist in the environment. Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental contaminants due to the incomplete combustion...
Heavy metals have historically been popular for use in cosmetics manufacturing due to the colorful pigmentation of heavy metal compounds. In the case of sindoor, a cosmetic used by married Hindu women for religious purposes, mercury sulfide, lead tetroxide, and lead chromate are compounds suspected to still be involved in...
Phytochemicals from the genus, Fagonia, have been attracting increasing attention due to their potential beneficial effects on human health, particularly, anti-cancer properties. Certain Fagonia species contain various types of phytochemicals such as saponins, alkaloids, cardiac glycosides, flavonoids, terpenoids, and tannins. In this study, we investigated the phytochemical composition of a...
Volatile organic compounds (VOCs) play an integral role in climate change and as a carbon source for organisms living in a marine environment. These compounds have many sources, but the impacts of biogenically produced VOCs is not fully known. Phaeodactylum tricornutum was studied under axenic ideal growth conditions to determine...
The Bcl-2 family of proteins regulate cell survival and are targets for cancer therapy. This protein family has also been implicated in chemotherapeutic resistance, the cause of approximately 90% of treatment failure in advanced cancer. We analyzed the expression and the role of the Bcl-2 proteins in chemotherapy resistant breast...
Flavonoids are a large family of compounds synthesized by plants that have a common chemical structure. It is believed that the health effects of fruits and vegetables are primarily due to dietary flavonoids content. Current research indicates that dietary flavonoids show promise for mitigating and/or preventing chronic conditions associated with...
Ubiquitous fine particulate matter (PM2.5) exposures significantly impact global public health, yet little is known about the mechanisms causing these known adverse health effects. Oxidative stress due to PM2.5 associated chemical constituents, such as polycyclic aromatic hydrocarbons (PAHs), is a proposed possible mechanism for PM2.5 mediated health effects. Variations in...
Cytochrome P450 1B1 (Cyp1B1) is a xenobiotic metabolizing enzyme, responsible for polycyclic aromatic hydrocarbon (PAH) oxidative metabolism. CYP1B1 metabolically activates several species of environmentally relevant procarcinogenic PAHs to reactive carcinogens. PAHs are aryl hydrocarbon receptor (AhR) agonists, leading to CYP1B1 upregulation. Though CYP1B1 is highly conserved across species, wild type...
Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...