If P is an integer polynomial denote the degree of P by ∂(P) and let H(P) be the maximum of the absolute value of the coefficients of P. Define Λ(P)=2[superscript ∂(P)]H(P) and for a fixed prime p let C[subscript p] denote the completion of the algebraic closure of the p-adic...
One group of four adult White Leghorn male chickens was fed a
diet containing 7.3% linoleic acid and 32.4 mg/ kg of added vitamin E
(group IV) for 50 weeks which was designated as the positive control.
A second lot (group I) containing 14 males received the same level of...
In this dissertation, we use Fourier-analytic methods to study questions of equidistribution on the compact abelian group Zp of p-adic integers. In particu- lar, we prove a LeVeque-type Fourier analytic upper bound on the discrepancy of sequences. We establish p-adic analogues of the classical Dirichlet and Fejér kernels on R/Z,...
A sucrose density-gradient ultracentrifugation technique for
obtaining microsomes has been developed. This technique has
advantages over the classic differential centrifugation technique, in
that it is faster, is better suited to work with small quantities of
tissue, and offers the opportunity to work with a defined microsomal
sub-cellular fraction, rather than...
Deep-sea bamboo coral (Isidella sp.) SE000901A from the southern Oregon coast (water depth 1048m) provides a high-resolution record of variability of North Pacific Intermediate Water (NPIW) and carbon rain to the sea floor, related to coastal upwelling, from 1808 to 2000AD. Counting of annual layers in magnesium to calcium (Mg/Ca)...
Full Text:
Appendix E: Environmental Indices
Table E1: Summer Upwelling
The induction of drug-metabolizing enzymes is a
complex biochemical process manifested not only by
increases in various cytochrome P-450 isozymes and
related activities, but also by alterations in
endoplasmic reticulum membranes. Little work has been
done to examine how cytochrome P-450 inducing agents
influence other cellular processes, such as
phospholipid...
Non-alcoholic Steatohepatitis (NASH) is an emerging form of liver disease associated with obesity, type II diabetes and dyslipidemia. As the prevalence of these metabolic conditions increases, so too has the occurrence of NASH in all sectors of the population. The pathology of this disease is similar to its alcoholic form,...
An in vitro study was conducted to investigate the metabolism and distribution of Se⁷⁵-selenite and Se⁷⁵-selenomethionine (SEM) in
chick blood. Se⁷⁵-selenite is taken up by RBC (13% within 20
minutes) and expelled into the plasma to become bound to proteins. In
contrast, Se⁷⁵-SEM showed a more gradual and continuous buildup...
The relative enrichment of skin sebaceous gland lipids with deuterium-labeled α-tocopherol was compared with plasma enrichment to evaluate the delivery of vitamin E to skin. For the first week of this study, each subject consumed a daily dose of deuterated vitamin E (150 mg of an equimolar mixture of RRR-α-[5-(C²H₃)]-(d₃)...
Aquatic animals are exposed to a variety of natural and
anthropogenic xenobiotics. Biotransformation of xenobiotics was
examined in three aquatic animals: a primitive mollusc (chiton);
a shellfish which is an important human food source (oyster);
and, a lower vertebrate model for toxicological studies (rainbow
trout). Since digestive glands of Cryntochiton...
The purpose of this watershed assessment is to provide an inventory and characterization of
watershed conditions in the Wilson River watershed and to provide recommendations that
address the issues of water quality, fisheries and fish habitat, and watershed hydrology.
Recommendations are provided in this watershed analysis to identify actions and management decisions on the part of BLM that might improve watershed health in the Trask River watershed.
The standard way of representing numbers on computers gives rise to errors
which increase as computations progress. Using p-adic valuations can reduce
error accumulation. Valuation theory tells us that p-adic and standard valuations
cannot be directly compared. The p-adic valuation can, however, be used in
an indirect way. This gives...
The primary goal of my study was to evaluate the effects of high dietary vitamin E on the rodent skeleton. The outcomes from my study assess the impact of high intakes of vitamin E and increased concentrations of its metabolite, carboxy ethyl hydroxy chromanol (CEHC), on bone turnover and skeletal...
Two lots of six White Leghorn male chickens were fed diets containing
7.3% linoleic acid and either .075% ethoxyquin (lot 1) or 32.4
mg/kg of added vitamin E (lot II) for 47 weeks both of which were
designated as positive controls. A third group (lot III) containing 30
males received...
Lipid peroxidation is believed to be an important
process in the development of cellular injury. In
addition to the degradation of biological membranes,
increasing evidence indicates that lipid peroxidation can
alter the structure and function of DMA.
The present study examines the peroxidation of
nuclear membranes and the capacity of...
Tocopherols are plant secondary metabolites that are known collectively as
vitamin E. Tocopherol compounds act as potent antioxidants by quenching free
radicals and protecting fatty acids from oxidative damage. In humans (in vivo)
tocopherols protect membrane lipids from breaking down, while in oils (in vitro)
tocopherols protect fatty acids from...
This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
A two-part study was conducted to investigate some of the nutritional
relationships between dietary tri-o-cresylphosphate (TOCP), a
toxic stress material, and dietary vitamin E and selenium. In part
one, growth rate of male weanling Long-Evans rats and day-old
Japanese quail (Coturnix coturnix japonica) was used to determine the
protective action...
Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
An anemia of juvenile chinook salmon (Oncorhynchus tshawytscha) is described and stages of development separated by recognizable syndromes. A vitamin E-deficient diet of low rancidity produced a severe microcytic anemia with strong immature red cell response and granulocytosis occurring 2 to 4 weeks before a drop in hemoglobin and hematocrit...
In this watershed assessment, the authors of the report summarized current conditions and data gaps within the Necanicum River watershed to help to identify how current and past resource management is impacting aquatic resources.
Two experiments were conducted to determine the effect of various levels of vitamin E on egg yolk. A diet of corn-flax-soybean meal was fed to layers and α-tocopherol content in eggs, egg production, and egg quality were evaluated. In experiment 2, vitamin E toxicity was also determined. In experiment 1,...
To determine whether extreme endurance exercise induces lipid peroxidation, we studied 14 athletes (5 females: 9 males) during a 50 km ultramarathon (trial 1) and during a sedentary protocol (trial 2) one month later. At dinner the evening before the race (or sedentary trial), subjects consumed vitamin E labeled with...
The research reported here was conducted to identify interests and needs among various sectors of the Oregon agricultural community regarding sustainable agriculture. The study also sought to gauge potential for establishing a program in Oregon to serve those needs.
The semiconductor gallium arsenide (GaAs) has many potential
advantages over the more widely used semiconductor silicon (Si).
These include higher low field mobility, semi-insulating substrates,
a direct band-gap, and greater radiation hardness. All these
advantages offer distinct opportunities for implementation of new
circuit functions or extension of the operating conditions...
This thesis investigates a way to fabricate P-N junctions by
percussive welding. The theoretical basis of percussive welding, design
considerations of the apparatus used, and the electrical characteristics
of the junctions were the main objectives of this investigation.
P-type silicon wafers and gold wire doped with arsenic as a
N-type...
Thermal decomposition of several di-p-toluenesulfonylhydrazones
was studied. It was found that the carbene decomposition
of tetramethyl-1,3-cyclobutanedione, di-p-toluenesulfonylhydrazone
gave two products resulting from
rearrangement. One was identified as 2,5-dimethyl-1,3,4-hexatriene. A tentative structure for the second was
proposed. During the course of the study, a more convenient
procedure for thermal decompositions was...
Work is presented which explores the properties and nature of
the P-form of DNA. Initially the P-form represented an unknown
state of DNA which occurred when this molecule was in a solvent of
47.5% methanol, 5% water, and 47.5% ethanol, and which showed properties
of both native and denatured conformations....
The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
Production Systems are languages widely used for the implementation of Artificial Intelligence projects. They support programs in which the sequence of instructions is not fully determined at the beginning of their execution, as well as 'event driven' programs (i.e. the occurrence of a particular element in the data set determines...
The Min protein system in Escherichia coli helps the cell division process by identifying the center of the cell [1, 7]. This system has been modeled succesfully computationally under standard conditions. There has been recent experimental interest in the cell division process for significantly perturbed cell shapes. We take the...
Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are polyunsaturated fatty acids required for proper embryonic development, specifically neurodevelopment. However, little is known regarding their conversion to other metabolites during embryogenesis. The oxidation of ARA gives rise to the biologically active eicosanoids and the oxidation of DHA gives rise to the...
Five species of aquatic organisms were exposed to TCDD. Lethal effects of initial exposure to coho salmon of 23.4 nanogram TCDD/gram fish wet weight (23.4 ng/g), or equivalent to 100 nanogram
per liter (100 ng/l) TCDD in water, for 24 hours were irreversible; 95% mortality occurred in 60 days. Exposure...
GaAs MESFETs are widely used in high speed integrated circuits (ICs) and
microwave circuits. Due to the materials and processing methods used in GaAs
MESFET fabrication, deep level traps in the substrate materials have a strong influence
on device performance.
In this work we used the drain current transient characterization...
Three highly purified forms of cytochrome P-450 (P-450a, P-450b, P-450c) from Aroclor 1254-induced rat hepatic microsomes catalyzed the monooxygenation of 1-(2- chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea (MeCCNU) and 1-(2-chloroethyl)-3-(cyclohexyl)-1-nitrosourea (CCNU) in the presence of purified NADPH cytochrome P-450 reductase, NADPH and oxygen. Cytochrome P -450- dependent monooxygenation of CCNU gave six alicyclic hydroxylation products...
In this thesis, we examined the effects of the exposures to anthropogenic pollutants on the fish, primarily juvenile chinook salmon, immune system using newly and recently developed immune assays. In addition, we developed a new assay for measuring immunocompetence of fish. In the first chapter, the Alamar Blue assay was...
The refresh times of all dynamic charge storage devices, best
characterized by the generation lifetime at roan temperature and the
recombination lifetime at higher device operating temperatures
(T>70°C), strongly influence the efficient and successful operation
of dynamic charge storage devices such as DRAM's and CCD's. Both
recombination and generation lifetime...
Phaseolus vulgaris, the common bean, is susceptible to many
bacterial, fungal and viral diseases. However, resistance to several
diseases has been identified in related Phaseolus species, P.
coccineus, P. acutifolius and P. lunatus. Thus, interspecific
hybridization could result in transfer of beneficial characteristics.
One of the problems encountered in interspecific...
This thesis describes a Mossbauer effect and electron
paramagnetic resonance study of iron (III) tetraphenylporphyrinatobenzenethiolate
benzene thiol, an analog compound
for bacterial cytochrome P-450. The compound is unusual in
that it provides a model for the two ferric reaction states
of cytochrome P-450. The iron in the model compound exhibits...
E+A galaxies represent an important niche in galaxy evolution as a subset of post-starburst galaxies. Set apart from other post-starburst galaxies by their rapid quenching of star formation, E+As are thought to have started their formation outside a galaxy cluster's center and have fallen inward due to gravity; the star...
Signals from the R/V Langseth’s tuned airgun array were recorded on an array of 33 EarthScope FlexArray seismometers deployed in the Oregon Coast Range from 43.5° to 45°N as part of the 2012 Ridge2Trench experiment to image the structure of the Juan de Fuca plate. This segment of the Juan...
Previous research has indicated several soil-applied herbicides
are more effective by exposure to emerging shoots than from
root uptake. Studies were conducted in the greenhouse and growth
chamber to investigate effects of herbicide placement in soil on
toxicity to emerging seedlings.
In these studies, an inch of treated soil was...
Previous research has shown that activated carbon is effective
in inactivating certain herbicides applied as a preemergence treatment.
Studies were conducted in the greenhouse to determine the
influence of various factors on the ability of activated carbon to
inactivate herbicides applied after carbon application. Field studies
were conducted to determine...
In recent years, the Promotion and Tenure process has been increasingly called into question by state lawmakers, public citizens, and even the academic community. With such questions in mind, Ball State University has worked to amend our promotion and tenure procedures to embrace inclusion and innovation, both by emphasizing the...
The present study investigated whether vitamin E supplementation reduced oxidative stress in erythrocytes and improved vitamin E status in patients undergoing hemodialysis (HD). Plasma and erythrocyte α-tocopherol, plasma ascorbic acid, and iron status were determined in 11 regular HD patients prior to and post-dialysis, before and during oral supplementation of...
In 1967, Doi et al. proposed the hypothesis that 'yellows type
diseases' are caused by mycoplasma. Since then more than 60
yellows diseases have been associated with mycoplasma-like bodies
(MLB) (Maramorosch, 1973). The majority of these associations are
based upon electron microscopic observations of mycoplasma-like
bodies in situ. However, little...
In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...
Patients with end-stage renal disease undergoing hemodialysis have a high incidence of oxidative stress-related diseases. This study evaluated oxidative stress and inflammatory markers in patients undergoing hemodialysis before and during vitamin E supplementation. Blood samples were obtained before and after dialysis during two separate dialysis sessions to establish baseline measurements....
When Biosand filters cannot be constructed with crushed quarry rock due to resource limitations, a suitable alternative filter media is needed. In this research, two crushed quarry rock alternatives were examined. Three bench-scale Biosand filters with crushed rock, beach sand, and heat-treated beach sand media were simultaneously dosed with Willamette...
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Table 4-5: Mean effluent E. coli concentration values and P-values for filters with
Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
Preliminary studies with a dog (Canis familiaris) and a coyote
(Canis latrans) showed that these carnivores can serve as definitive
hosts in the life cycle of Sarcocystis fusiformis of cattle (Bos
taurus) and a microscopic Sarcocystis of mule deer (Odocoileus
hemionus hemionus). Preliminary studies to determine effects of the
cervine...
Sperm mobility is defined as the net movement of a sperm population against resistance. Previous research demonstrated that the cell-permeant Ca2+ indicator rhod-2 AM gave a fluorescent signal predominantly in the head region of fowl sperm that differed between sperm mobility phenotypes. This thesis served to explore the role of...
In order to investigate potential climate impacts on landscape-scale ecosystem processes, I implemented a dynamic general vegetation model (DGVM) over a large domain in northern California and western Nevada on a rectangular grid of ca. 800-meter spatial resolution. I used 100 years of observed, monthly climate and nine future climate...
As genome sequencing projects begin to come to completion, the challenge becomes one of determining how to understand the information contained within the DNA. DNA is a polymorphic macromolecule; the A- B- and Z-DNA conformations have been observed by a variety of physical techniques. The magnitude of the energetic differences...
The growth of Brettanomyces bruxellensis is a major cause of wine spoilage due tothe production of the volatile phenols 4-ethylphenol (4-EP) and 4-ethylguaiacol (4-EG), derivatives of p-coumaric acid and ferulic acid. During the winemaking process,some microorganisms can impact the concentration of the 4-EP precursors pcoumaricand coutaric acid (tartaric acid-esterified p-coumaric...
A series of compounds, 7-8 and 20-25, were tested as competitive inhibitors of 2,5-dihydroxyacetanilide epoxidase I (DHAE I) and DHAE II. A Hammett plot was constructed for each enzyme to determine the effect of electron density on inhibition. DHAE I gave a linear, highly correlated plot (r²=0.91) that signifies the...
Climate change impacts everyone’s food and water security. Increasing global temperatures accelerate the hydrologic cycle and consequently impact the water resources for billions of people worldwide. Countless models have been developed to represent various components of the hydrologic cycle at various spatial and temporal scales. These are often validated against...
Large igneous provinces (LIPs) and intraplate seamounts reflect of anomalous mantle melting and illuminate interior processes of the Earth. These features are in all ocean basins and show the mantle’s evolution over time, then can provide information on plate tectonic processes, such as plate motion over time, spreading ridge formation,...
Teachers may be attracted to the use of a game in a learning activity under the presumption that students will find the game experience to be more “fun” than typical classroom activities. The use of a game in a learning activity should help students attain important learning outcomes and engage...
: ________________________________________________________________
Thomas P. Dick
Teachers may be attracted to the use of a game in a learning activity
A series of field experiments was conducted during 1975 and
1976 to examine peppermint tolerance and Canada, thistle response to
Dowco 290 (3, 6- dichloropicolinic acid). Peppermint oil yield and
Canada thistle density were considered most important in evaluating
experimental results.
Peppermint tolerance to Dowco 290 was studied in weed-free...
This study examined the experience of three secondary
science student teachers from Western Oregon State College
in Monmouth, Oregon during the Spring quarter of 1990. The
question was: What is student teaching like from the point
of view of the student teacher?
The research methodology was qualitative, more
specifically participant...
A series of experiments were conducted from 1983 to 1985 to
determine the effects of dinoseb [2-(1-methylpropyl)-4,6-dinitrophenol]
on winter wheat (Triticum aestivum L. em Thell) yields. Field trials
on dinoseb timing and dinoseb plus supplemental pesticides were
established in an effort to elucidate the possible factors involved in
the yield...
Life on Earth intimately depends on the function of countless proteins. For the majority of studied proteins, function absolutely depends on conformation (i.e. 3-dimensional shape in solution). The exact nature of how a protein goes from an unfolded linear polypeptide chain to an organized folded molecule is still not known,...
Achromobacter A43 produced a compound inhibitory to the outgrowth
of Clostridium botulinum type E spores. The inhibitor could
be produced in various laboratory media and the outgrowth of germinated
spores was completely inhibited by 1/10th dilution of the A43
spent medium. Germination was not affected. The spores lost
refractility in...
Milk fever (MF), retained placenta (RP), and left displaced abomasum (LDA) are three common and costly metabolic diseases in cows during the first days of lactation. Some studies suggest that circulating concentrations of α-tocopherol (ATOC) are decreased by these three diseases. It is, however, unknown if and how long lower...
The slope parameter "a" of the π ° - electromagnetic transition form factor was obtained from a measurement of the partial branching ratio of the Dalitz decay π° - e⁺ e⁻ y into high invariant-mass electron-positron pairs. The experiment was carried out at the TRIUMF cyclotron laboratory. A beam of...
Cystic ovarian disease (COD) is an anovulatory condition in cattle
that afflicts between 6-18% of all dairy cows in the US. Ovulation is
dependent on the plasminogen activator (PA) family of proteases
and protease inhibitor for proteolysis, culminating in follicular rupture.
Failure of the follicle to ovulate suggests an aberration...
Cognitive impairment, or cognitive decline, a noticeable and measurable decline in cognitive abilities (e.g. memory and learning) that exceeds those attributed to normal aging, represents an early symptom of neurodegeneration and increased risk for progression to more severe dementias, such as Alzheimer's disease (AD). While the complex etiology of these...
BaCuChF (Ch = S, Se, Te) materials are chalcogen-based transparent conductors with wide optical band gaps (2.9 – 3.5 eV) and a high concentration of free holes (10¹⁸ – 10²⁰ cm⁻³) caused by the presence of copper vacancies. Chalcogen vacancies compensate copper vacancies in these materials, setting the Fermi level...
Disposal of chlorinated hydrocarbons is a major environmental concern due to the lack of a satisfactory means of safe remediation at all contaminated locations. Current technologies rely primarily on incineration, a process that can lead to dangerous byproducts such as dioxin. If the chlorine substituent can be removed prior to...
The height of an algebraic number A is a measure of how arithmetically complicated A is. We say A is totally p-adic if the minimal polynomial of A splits completely over the field of p-adic numbers. In this paper, we investigate what can be said about the smallest nonzero height...
The study on a p-n junction gallium arsenide avalanche photodiode
is reported. The procedures of the fabrication of the diodes
and the measurement of the device performance in terms of photomultiplication
factors are described. The photodiode is mesa type
with an active diameter of 60 microns, and the junction depth...
The primary focus of this thesis involves modeling and development of p-type thin-film transistors (p-TFTs), moving towards the realization of a filly transparent thin-film transistor (TTFT). The modeling portion of this thesis emphasizes the development of physics-based TFT models, specifically focusing on the elucidation of non-ideal current-voltage characteristic behavior. A...
Seismic refraction data collected in 1985 by the USGS were used in
this study to derive the P and S velocity structure of the crust beneath the
Gulf of Maine. The data quality differs among instruments and is affected
by surficial lateral heterogeneities, a ringy source signature and
reverberations. Velocity...
Monoclonal antibodies were developed against serotype 3, P-1059 strain of Pasteurella multocida. Enzyme-linked immunosorbent assays (ELISA) were used to detect antibodies in supernatants of hybridoma cells to either a surface protective (2.5 S) antigen prepared from a 2.5% saline extract or lipopolysaccharide (LPS) prepared by the phenol-water method. Forty two...
E-commerce has begun to evolve beyond simple web pages to more sophisticated ways of conducting e-business transactions, such as through electronic advertising, negotiation, and delivery. However, to participate in these advances requires the skills of professional programmers, and end-user owners of small businesses often cannot justify this expense. In this...